Results 101 to 110 of about 6,021 (217)
PLoS ONE, 2012 The gamma-secretase complex is involved in the intramembranous proteolysis of a variety of substrates, including the amyloid precursor protein and the Notch receptor.
Jung-Soon Mo +10 more
doaj +1 more source
European Journal of Neuroscience, Volume 62, Issue 4, August 2025.Cannabidiol improves several Alzheimer's‐related aspects and regulates disease‐associated genes. Literature review and Over‐Representation Analysis of 64 genes confirm its effects on key mechanisms such as amyloid‐β and tau processing, oxidative stress, inflammation, and lipid metabolism.
João V. Mello‐Hortega +5 more
wiley +1 more source
Neurobiology of Disease, 2003 γ-Secretase is a proteolytic complex whose substrates include Notch, β-amyloid precursor protein (APP), and several other type I transmembrane proteins. Presenilin (PS) and nicastrin are known components of this high-molecular-weight complex, and recent ...
Stephanie Baulac +6 more
doaj +1 more source
Health Science Reports, Volume 8, Issue 7, July 2025.ABSTRACT Background and Aims Alzheimer's disease (AD), a chronic neurodegenerative disorder, is portrayed by neurocognitive decline in the structure and function of the human brain. Various factors are implicated in the pathogenesis to neuroplasticity alteration in the brain of an individual afflicted with AD.
Abir Ghosson +4 more
wiley +1 more source
Autophagy and Cellular Senescence in Alzheimer's Disease: Key Drivers of Neurodegeneration
CNS Neuroscience &Therapeutics, Volume 31, Issue 7, July 2025.Impaired autophagy in Alzheimer's disease leads to accumulation of amyloid‐β and tau aggregates, while senescent brain cells secrete pro‐inflammatory SASP factors. The interplay between defective clearance and chronic inflammation accelerates neuronal dysfunction and highlights autophagy enhancers and senolytics as promising therapeutic strategies ...
Md Sadique Hussain +11 more
wiley +1 more source
Navigating the treatment landscape of Alzheimer's disease: Current strategies and future directions
Ibrain, Volume 11, Issue 2, Page 162-184, Summer 2025.Alzheimer's disease treatment is evolving rapidly, with emerging strategies targeting multiple disease pathways. This graphical abstract highlights the shift from traditional therapies to innovative approaches that hold promise for improving outcomes.
Tapas Kumar Mohapatra +4 more
wiley +1 more source
Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor [PDF]
, 2009 Alzheimer-disease-associated beta-amyloid (A beta) is produced by sequential endoproteolysis of beta-amyloid protein precursor (beta APP): the extracellular portion is shed by cleavage in the juxtamembrane region by beta-amyloid-cleaving enzyme (BACE ...
Dohi, Keiji +27 more
core +1 more source
Neurobiology of Disease, 2007 γ-Secretase is a protease complex, which catalyzes the final of two subsequent cleavages of the β-amyloid precursor protein (APP) to release the amyloid-β peptide (Aβ) implicated in Alzheimer’s disease (AD) pathogenesis.
Keiro Shirotani +4 more
doaj +1 more source
When, where and how? Focus on neuronal calcium dysfunctions in Alzheimer's Disease. [PDF]
, 2016 Alzheimer\u2019s disease (AD), since its characterization as a precise form of dementia with its own pathological hallmarks, has captured scientists\u2019 attention because of its complexity.
AGOSTINI, MARIO, FASOLATO, CRISTINA
core +1 more source
Oxidative stress and lipid peroxidation are upstream of amyloid pathology
Neurobiology of Disease, 2015 Oxidative stress is a common feature of the aging process and of many neurodegenerative disorders, including Alzheimer's disease. Understanding the direct causative relationship between oxidative stress and amyloid pathology, and determining the ...
Muriel Arimon +5 more
doaj +1 more source