Results 121 to 130 of about 6,021 (217)
Alzheimer's Amyloid-β is an Antimicrobial Peptide: A Review of the Evidence [PDF]
, 2018 The final publication is available at IOS Press through http://dx.doi.org/10.3233/JAD-171133.The amyloid-β (Aβ) peptide has long been considered to be the driving force behind Alzheimer’s disease (AD).
Brothers, Holly +2 more
core +1 more source
Screening nicastrin antibodies for specificity for immunofluorescence (934.2)
The FASEB Journal, 2014 Alzheimer’s disease is a type of dementia that can cause problems with memory, learning and behavior. Nicastrin is a component of the protein complex involved in the development of Alzheimer’s disease. In our lab, tissue‐specific nicastrin conditional knockout mice were developed and displayed a striking neurological phenotype. The aim of this research
Derek Deshaies, Gang Yu, Daniel Dries
openaire +1 more source
ChemPhysMaterGamma secretase (GS) is an intramembranous enzyme that acts on the amyloid precursor protein and Notch inside lipid membranes. The enzyme is responsible for amyloid-β propagation, one of the well-known causes of Alzheimer's disease.
Ahmad Sajjad +3 more
doaj +1 more source
Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs [PDF]
, 2017 Recent studies demonstrate that presenilins (PSs) and signal peptide peptidase (SPP) are members of a novel protease family of integral membrane proteins that may utilize a catalytic mechanism similar to classic aspartic proteases such as pepsin, renin ...
Golde, Todd E., Martoglio, Bruno
core
Nicastrin Mutations in French Families with Hidradenitis Suppurativa [PDF]
Journal of Investigative Dermatology, 2012 Miskinyte, Snaigune +6 more
openaire +2 more sources
Physical activity and beta-amyloid pathology in Alzheimer's disease [PDF]
, 2017 Alzheimer's disease (AD) is the most common type of dementia worldwide. Since curative treatment has not been established for AD yet and due to heavy financial and psychological costs of patients’ care, special attention has been paid to preventive ...
Baghaiee, Behrouz +4 more
core
POTENTIAL ALTERATION IN THE NICASTRIN LEVELS IN ALZHEIMER’S DISEASE CEREBROSPINAL FLUID
IBRO Neuroscience Reports, 2023 Luis Felipe Hernández-Villamizar +5 more
doaj +1 more source
Interaction of Substrates with γ-Secretase at the Level of Individual Transmembrane Helices-A Methodological Approach. [PDF]
Int J Mol Sci, 2023 Pauli TM +9 more
europepmc +1 more source