Results 1 to 10 of about 26,623 (217)

The Alzheimer's disease β-secretase enzyme, BACE1 [PDF]

Molecular Neurodegeneration, 2007
The pathogenesis of Alzheimer's disease is highly complex. While several pathologies characterize this disease, amyloid plaques, composed of the β-amyloid peptide are hallmark neuropathological lesions in Alzheimer's disease brain.
Vassar Robert, Cole Sarah L
doaj   +6 more sources

Bace1 activity impairs neuronal glucose metabolism: rescue by beta-hydroxybutyrate and lipoic acid [PDF]

Frontiers in Cellular Neuroscience, 2015
Glucose hypometabolism and impaired mitochondrial function in neurons have been suggested to play early and perhaps causative roles in Alzheimer’s disease (AD) pathogenesis. Activity of the aspartic acid protease, beta-site amyloid precursor protein (APP)
John A Findlay, David Lee Hamilton, Michael Lawrence James Ashford   +2 more
doaj   +11 more sources

Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit [PDF]

Molecular Neurodegeneration, 2010
Background The voltage-gated sodium channel β2 subunit (Navβ2) is a physiological substrate of BACE1 (β-site APP cleaving enzyme) and γ-secretase, two proteolytic enzymes central to Alzheimer's disease pathogenesis.
Kovacs Dora M, Bhattacharyya Raja, Kim Doo, Gersbacher Manuel T   +3 more
doaj   +6 more sources

BACE1 regulates sleep–wake cycle through both enzymatic and non–enzymatic actions [PDF]

EMBO Reports
The β-secretase BACE1 has become a prime target in Alzheimer’s disease (AD) therapy, because it drives the production of pathogenic amyloid β peptides.
Hannah Heininger, Xiao Feng, Alp Altunkaya, Fang Zheng, Florian Stockinger, Benedikt Wefers, Stephan A Müller, Pieter Giesbertz, Sarah K Tschirner, Dorina Shqau, Helmuth Adelsberger, Alexey Ponomarenko, Thomas Fenzl, Christian Alzheimer, Stefan F Lichtenthaler, Tobias Huth   +15 more
doaj   +2 more sources

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis [PDF]

Journal of Neuroinflammation, 2011
Background β-Amyloid (Aβ) plays a central role in Alzheimer's disease (AD) pathogenesis. Neurons are major sources of Aβ in the brain. However, astrocytes outnumber neurons by at least five-fold. Thus, even a small level of astrocytic Aβ production could
Vassar Robert, O'Connor Tracy, Zhao Jie
doaj   +3 more sources

Insights from Drosophila melanogaster model of Alzheimer's disease

Frontiers in Bioscience-Landmark, 2020
Alzheimer’s disease (AD) is a common chronic neurodegenerative disease that mainly affects the medial temporal lobe and associated neocortical structures. The disease process involves two abnormal structures, plaques and tangles, which damage and destroy
Nguyen Trong Tue, Tran Quoc Dat, Luong Linh Ly, Vu Duc Anh, Hideki Yoshida   +4 more
doaj   +1 more source

Phospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice. [PDF]

PLoS ONE, 2010
β-Site APP-cleaving enzyme 1 (BACE1) initiates amyloid-β (Aβ) generation and thus represents a prime therapeutic target in treating Alzheimer's disease (AD). Notably, increasing evidence indicates that BACE1 levels become elevated in AD brains as disease
Latha Devi, Masuo Ohno
doaj   +1 more source

The Emerging Roles of the β-Secretase BACE1 and the Long Non-coding RNA BACE1-AS in Human Diseases: A Focus on Neurodegenerative Diseases and Cancer

Frontiers in Aging Neuroscience, 2022
The β-Secretase (BACE1) is widely studied to be particularly involved in amyloid deposition, a process known as the pathogenic pathway in neurodegenerative diseases. Therefore, BACE1 expression is frequently reported to be upregulated in brain samples of
Arezou Sayad, Sajad Najafi, Bashdar Mahmud Hussen, Bashdar Mahmud Hussen, Sara Tharwat Abdullah, Ahmad Movahedpour, Mohammad Taheri, Mohammadreza Hajiesmaeili, Mohammadreza Hajiesmaeili   +8 more
doaj   +1 more source

The Alzheimer’s disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130

Molecular Neurodegeneration, 2023
Background The protease BACE1 is a major drug target for Alzheimer’s disease, but chronic BACE1 inhibition is associated with non-progressive cognitive worsening that may be caused by modulation of unknown physiological BACE1 substrates.
Stephan A. Müller, Merav D. Shmueli, Xiao Feng, Johanna Tüshaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose-John, Matthew E. Kennedy, Stefan F. Lichtenthaler   +10 more
doaj   +1 more source

BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

Molecular Neurodegeneration, 2023
Background Abnormal accumulation of amyloid beta peptide (Aβ) in the brain induces a cascade of pathological changes in Alzheimer’s disease (AD), and inhibiting BACE1, which is required for Aβ generation, is therefore being explored for the treatment of ...
John Zhou, Neeraj Singh, James Galske, Jacob Hudobenko, Xiangyou Hu, Riqiang Yan   +5 more
doaj   +1 more source