Results 41 to 50 of about 26,623 (217)
Molecular Neurodegeneration, 2011 Background The β-secretase, β-site amyloid precursor protein cleaving enzyme 1 (BACE1), is a prime therapeutic target for lowering cerebral β-amyloid (Aβ) levels in Alzheimer's disease (AD).
Rajapaksha Tharinda W +3 more
doaj +1 more source
Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase [PDF]
, 2014 BACKGROUND: BACE1 is one of the two enzymes that cleave amyloid precursor protein to generate Alzheimer's disease (AD) beta amyloid peptides. It is widely believed that BACE1 initiates APP processing in endosomes, and in the brain this cleavage is known ...
Celia G Fernandez +8 more
core +1 more source
BACE1 Inhibition Increases Susceptibility to Oxidative Stress by Promoting Mitochondrial Damage
Antioxidants, 2021 BACE1 is a key enzyme facilitating the generation of neurotoxic β-amyloid (Aβ) peptide. However, given that BACE1 has multiple substrates we explored the importance of BACE1 in the maintenance of retinal pigment epithelial (RPE) cell homeostasis under ...
Carolina Francelin +10 more
doaj +1 more source
An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]
, 2015 Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro +1 more
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The Sodium Channel B4-Subunits are Dysregulated in Temporal Lobe Epilepsy Drug-Resistant Patients [PDF]
, 2020 Temporal lobe epilepsy (TLE) is the most common type of partial epilepsy referred for surgery due to antiepileptic drug (AED) resistance. A common molecular target for many of these drugs is the voltage-gated sodium channel (VGSC).
Falciani, Francesco +4 more
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Modeling Potenial BACE1 Inhibitors
The FASEB Journal, 2018 A wealth of evidence suggests that aggregated amyloid beta (AB) peptide deposits in the brain play a central role in the pathogenesis of Alzheimer's disease (AD). The rate determining step in AB production is catalyzed by the beta‐site amyloid precursor protein cleaving enzyme 1 (BACE1); hence, BACE1 is a therapeutic target for AD.
Johnny Guevara +2 more
openaire +1 more source
Ubiquitin Regulates GGA3-mediated Degradation of BACE1 [PDF]
Journal of Biological Chemistry, 2010 BACE1 (beta-site amyloid precursor protein-cleaving enzyme 1) is a membrane-tethered member of the aspartyl proteases, essential for the production of beta-amyloid, a toxic peptide that accumulates in the brain of subjects affected by Alzheimer disease. The BACE1 C-terminal fragment contains a DXXLL motif that has been shown to bind the VHS (VPS27, Hrs,
Kang, E +4 more
openaire +3 more sources
BACE1 activity regulates cell surface contactin-2 levels [PDF]
, 2014 Background: Although BACE1 is a major therapeutic target for Alzheimer’s disease (AD), potential side effects of BACE1 inhibition are not well characterized. BACE1 cleaves over 60 putative substrates, however the majority of these cleavages have not been
D’Avanzo, Carla +4 more
core +1 more source
Basic and Clinical Neuroscience, 2020 Objective: Hypoxia via expression of Hypoxia Inducible Factor-1 (HIF-1) is an important and effective factor in the onset and progression of memory disorders such as Alzheimer Disease (AD).
Fahimeh Fahimi Truski +3 more
doaj
MicroRNAs in age-related diseases [PDF]
, 2013 Aging is a complex process that is linked to an increased incidence of major diseases such as cardiovascular and neurodegenerative disease, but also cancer and immune disorders.
Jazbutyte V +4 more
core +1 more source