Results 11 to 20 of about 26,623 (217)
Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing [PDF]
Molecular Neurodegeneration, 2012 Abstract Background β-site APP cleaving enzyme 1 (BACE1) cleaves β-amyloid precursor protein (APP) to initiate the production of β-amyloid (Aβ), the prime culprit in Alzheimer’s disease (AD). Dysregulation of the intracellular trafficking of BACE1 may affect Aβ generation, contributing to AD pathology.
Zhao, Yonghao +6 more
openaire +4 more sources
Characterization of Cerebrospinal Fluid BACE1 Species [PDF]
Molecular Neurobiology, 2019 The β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the main brain β-secretase responsible for the amyloidogenic processing of the amyloid precursor protein (APP). Previous studies have suggested that cerebrospinal fluid (CSF) β-secretase activity may be a candidate diagnostic biomarker for Alzheimer's disease (AD), but biochemical ...
Inmaculada Lopez-Font +4 more
openaire +7 more sources
Molecules, 2020 A molecular imaging probe to fluorescently image the β-site of the amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) and cathepsin D (CatD) enzymes associated with Alzheimer’s disease (AD) was designed and synthesized.
Jenny M. Tam +3 more
doaj +1 more source
Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis
Scientific Reports, 2023 The beta‑site amyloid precursor protein (APP) cleaving enzyme (BACE1) was discovered due to its “amyloidogenic” activity which contributes to the production of amyloid-beta (Aβ) peptides. However, BACE1 also possesses an “amyloidolytic” activity, whereby
Irem Ulku +10 more
doaj +1 more source
Drug Delivery, 2020 Therapeutic drugs for Alzheimer’s disease have been extensively studied due to its recurrence and abundance among neurodegenerative diseases. It is thought that the accumulation of amyloid precursor protein (APP) products, a consequence of an up ...
Natalia Lopez-Barbosa +8 more
doaj +1 more source
BACE1: Now We Can See You [PDF]
Journal of Medicinal Chemistry, 2018 No in vivo imaging biomarker currently exists for BACE, a drug target for Alzheimer's disease (AD). A strategy aiming to find a novel brain-penetrant positron emission tomography (PET) radiotracer for BACE1 led to the discovery of a highly potent and selective aminothiazine inhibitor, PF-06684511.
Salvatore Bongarzone, Antony D. Gee
openaire +5 more sources
Early elevation of BACE1 in dementia
Aging, 2021 Interest in the role of Beta-secretase1 (BACE1) in Alzheimer’s disease (AD) pathogenesis and patho-physiology has been remarkably growing in the last 10 ...
Cervellati C., Valacchi G., Zuliani G.
openaire +2 more sources
Metal-Supramolecular Drug Delivery System Empowered Meningeal Lymphatic Vessels-Bridged Intracranial-Peripheral Dual Immune Modulation for Reversing Glioblastoma Immune Suppression. [PDF]
Adv Sci (Weinh)A novel metal‐supramolecular nanoplatform (FLM@VC) enables efficient brain delivery via meningeal lymphatic vessels (MLVs), bypassing the blood‐brain barrier (BBB) through subcutaneous administration. It reprograms tumor‐associated macrophages (TAMs) and remodels the MLVs to promote DC trafficking and CD8+ T cell activation.
Zhang C +11 more
europepmc +2 more sources
Peptidomimetic Modulators of BACE1 [PDF]
Australian Journal of Chemistry, 2020 The β-site APP Cleaving enzyme 1 (BACE1) is a membrane-associated aspartyl protease which mediates the production of amyloid-β (Aβ), a major component of amyloid plaques in the Alzheimer’s disease brain. We have synthesised and characterised a series of peptidomimetic analogues of BACE substrates that incorporate two distinct stabilising structures. To
John Paul Juliano +2 more
openaire +1 more source
Journal of Experimental & Clinical Cancer Research, 2023 Background Liver metastasis is one of the most important reasons for high mortality of colorectal cancer (CRC). Growing evidence illustrates that lncRNAs play a critical role in CRC liver metastasis.
Xidi Wang +4 more
doaj +1 more source