Results 91 to 100 of about 6,021 (217)

Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin.

PLoS ONE, 2013
Dysregulation of the proteolytic processing of amyloid precursor protein by γ-secretase and the ensuing generation of amyloid-β is associated with the pathogenesis of Alzheimer's disease.
Nina Stemmer, Elena Strekalova, Nevena Djogo, Frank Plöger, Gabriele Loers, David Lutz, Friedrich Buck, Marek Michalak, Melitta Schachner, Ralf Kleene   +9 more
doaj   +1 more source

Probing the secrets of Alzheimer's disease using human-induced pluripotent stem cell technology. [PDF]

, 2014
Our understanding of Alzheimer's disease (AD) is still incomplete and, as a result, we lack effective therapies. Reprogramming to generate human-induced pluripotent stem cells provides a new approach to the generation of human neurons that carry the ...
Goldstein, Lawrence SB, Reyna, Sol, Woodruff, Grace   +2 more
core   +1 more source

Pharmacological And Genetic Reversal Of Age-Dependent Cognitive Deficits Attributable To Decreased Presenilin Function [PDF]

, 2010
Alzheimer\u27s disease (AD) is the leading cause of cognitive loss and neurodegeneration in the developed world. Although its genetic and environmental causes are not generally known, familial forms of the disease (FAD) are attributable to mutations in a
Bell, A. J., Chiorean, S., Choi, C. H., Choi, R. J., Ferreiro, D., Ferrick, N. J., Fortini, M. E., Hinchey, P., Jongens, T. A., Koenigsberg, E., Kollaros, M., Liebelt, D. A., McBride, S. M.J., McDonald, T. V., Nguyen, H. T., Rudominer, R. L., Schoenfeld, B. P., Siwicki, Kathleen King, Sumida, A., Terlizzi, A. M.   +19 more
core   +2 more sources

Nontranscriptional Role of Hif-1α in Activation of γ-Secretase and Notch Signaling in Breast Cancer

Cell Reports, 2014
γ-Secretase is composed of four proteins that are obligatory for protease activity: presenilin, nicastrin, Aph1, and Pen-2. Despite the progress toward understanding the function of these individual subunits, there is no information available pertaining ...
Jennifer C. Villa, Danica Chiu, Alissa H. Brandes, Freddy E. Escorcia, Carlos H. Villa, William F. Maguire, Cheng-Jun Hu, Elisa de Stanchina, M. Celeste Simon, Sangram S. Sisodia, David A. Scheinberg, Yue-Ming Li   +11 more
doaj   +1 more source

Serum vitamin D in patients with mild cognitive impairment and Alzheimer's disease [PDF]

, 2018
Objectives: To determine the relevance of Mini-Mental State Examination (MMSE), serum 25-hydroxyvitamin D (25(OH)D3), and 1,25(OH)2D3 concentrations to mild cognitive impairment (MCI) and various stages of Alzheimer's disease (AD). Materials and Methods:
Bölükbaşı Hatip, Funda Fatma, Hatip-Al-Khatib, I., Matsunaga, Y., Ouma, S., Suenaga, M., Tsuboi, Y.   +5 more
core   +1 more source

Cellular localization of Nicastrin affects amyloid β species production

FEBS Letters, 2008
The γ‐secretase complex, composed by presenilin, nicastrin, APH‐1 and PEN‐2, is involved in intramembranous proteolysis of membrane proteins, such as amyloid precursor protein or Notch. Cleavage occurs in multiple cellular compartments. Here, nicastrin mutants containing targeting signals to the endoplasmic reticulum, trans‐Golgi network, lysosomes, or
Morais, Vanessa A., Leight, Susan, Pijak, Donald S., Lee, Virginia M.-Y., Costa, Júlia   +4 more
openaire   +2 more sources

A Scoping Review of Pathogenesis, Current Treatments, and Novel Approaches for Vitiligo

Journal of Cosmetic Dermatology, Volume 24, Issue 10, October 2025.
ABSTRACT Background Vitiligo is a chronic skin disorder characterized by loss of melanocytes, causing depigmentation and psychological distress. Its pathogenesis is complex and multifactorial, involving genetic predisposition, autoimmune, oxidative stress, and neurogenic mechanisms.
Nusaibah Sallehuddin, Nur Izzah Md Fadilah, Mh Busra Fauzi, Manira Maarof   +3 more
wiley   +1 more source

NCSTN promotes hepatocellular carcinoma cell growth and metastasis via β-catenin activation in a Notch1/AKT dependent manner

Journal of Experimental & Clinical Cancer Research, 2020
Background Hepatocellular carcinoma is the third top cause of cancer-related mortalities worldwide. The prognosis of HCC patients remains poor due to rapid progression and high incidence of tumor recurrence.
Hui Li, Tian Lan, Lin Xu, Hailing Liu, Jinju Wang, Jiaxin Li, Xiangzheng Chen, Jiwei Huang, Xuefeng Li, Kefei Yuan, Yong Zeng, Hong Wu   +11 more
doaj   +1 more source

Vitamin D receptor is present on the neuronal plasma membrane and is co-localized with amyloid precursor protein, ADAM10 or Nicastrin. [PDF]

PLoS ONE, 2017
Our recent study indicated that vitamin D and its receptors are important parts of the amyloid processing pathway in neurons. Yet the role of vitamin D receptor (VDR) in amyloid pathogenesis is complex and all regulations over the production of amyloid ...
Erdinç Dursun, Duygu Gezen-Ak
doaj   +1 more source

Senescence Alters Antimicrobial Peptide Expression and Induces Amyloid‐β Production in Retinal Pigment Epithelial Cells

Aging Cell, Volume 24, Issue 9, September 2025.
Healthy RPE cells produce AMPs and AMP precursors, including amyloid precursor protein (APP) and chemerin, and protect the neuroretina from blood‐borne pathogens and maintain homeostasis. When RPE cells undergo senescence, the antibacterial activity declines, and APP undergoes amylogenesis, leading to Aβ deposition.
Jian Liu, Caijiao Yi, Jinyan Qi, Xuexue Cui, Xiangling Yuan, Wen Deng, Mei Chen, Heping Xu   +7 more
wiley   +1 more source