Results 81 to 90 of about 6,021 (217)

Γ-secretase components as predictors of breast cancer outcome.

PLoS ONE, 2013
γ-secretase is a large ubiquitously expressed protease complex composed of four core subunits: presenilin, Aph1, PEN-2, and nicastrin. The function of γ-secretase in the cells is to proteolytically cleave various proteins within their transmembrane ...
Hanna M Peltonen, Annakaisa Haapasalo, Mikko Hiltunen, Vesa Kataja, Veli-Matti Kosma, Arto Mannermaa   +5 more
doaj   +1 more source

Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity

Molecular Neurodegeneration, 2020
The activity of γ-secretase is critical to the pathogenesis of Alzheimer’s disease (AD). How its activity is regulated is intriguing and highly important for any AD therapy that focuses on reduction of toxic amyloid peptides and amyloid deposition in ...
Annie Y. Yao, Riqiang Yan
doaj   +1 more source

Chronic administration of anti-stroke herbal medicine TongLuoJiuNao reduces amyloidogenic processing of amyloid precursor protein in a mouse model of Alzheimer's disease. [PDF]

PLoS ONE, 2013
Composed of Ginsenoside Rg1 and Geniposide, the herbal medicine TongLuoJiuNao (TLJN) injection liquid has anti-inflammatory properties and can improve learning and memory in mice.
Ping He, Pengtao Li, Qian Hua, Yuan Liu, Matthias Staufenbiel, Rena Li, Yong Shen   +6 more
doaj   +1 more source

S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1 [PDF]

Journal of Biological Chemistry, 2009
Proteolytic processing of amyloid precursor protein (APP) by beta- and gamma-secretases generates beta-amyloid (Abeta) peptides, which accumulate in the brains of individuals affected by Alzheimer disease. Detergent-resistant membrane microdomains (DRM) rich in cholesterol and sphingolipid, termed lipid rafts, have been implicated in Abeta production ...
Haipeng, Cheng, Kulandaivelu S, Vetrivel, Renaldo C, Drisdel, Xavier, Meckler, Ping, Gong, Jae Yoon, Leem, Tong, Li, Meghan, Carter, Ying, Chen, Phuong, Nguyen, Takeshi, Iwatsubo, Taisuke, Tomita, Philip C, Wong, William N, Green, Maria Z, Kounnas, Gopal, Thinakaran   +15 more
openaire   +2 more sources

From Yeast to Therapeutics: Modeling Neurodegenerative Diseases in Saccharomyces cerevisiae

Yeast, Volume 42, Issue 12, Page 283-302, December 2025.
Yeast plasmids expressing human Aβ‐42, α‐syn, htt, and TDP‐43. Their fate includes an equilibrium between the endocytic pathway and aggregates that potentially disrupt endocytosis, vesicular transport, vacuolar autophagy, and mitochondrial activity. ABSTRACT Here, we review the use of Saccharomyces cerevisiae as a powerful model organism for studying ...
Jose Ribamar Ferreira‐Junior, Vittoria de Lima Camandona, Mario H. Barros   +2 more
wiley   +1 more source

Association of cerebrospinal fluid Aβ42 with A2M gene in cognitively normal subjects [PDF]

, 2014
Low cerebrospinal fluid (CSF) Aβ42 levels correlate with increased brain Aβ deposition in Alzheimer’s disease (AD), which suggests a disruption in the degradation and clearance of Aβ from the brain.
Bekris, Lynn M., Farlow, Martin R., Galasko, Douglas R., Kaye, Jeffrey A., Leverenz, James B., Li, Ge, Lutz, Franziska, Millard, Steven P., Peskind, Elaine R., Quinn, Joseph F., Tsuang, Debby, Yu, Chang-En   +11 more
core   +2 more sources

P3‐336: Purification and cocrystallization of nicastrin ectodomain [PDF]

Alzheimer's & Dementia, 2008
Alzheimer's & Dementia: The Journal of the Alzheimer's Association 4 (2008) T620-T620.
University of Chicago, Chicago, IL, USA ( host institution ), Lin, Guoqing, Kim, Seong-Hun, Leung, Brenda, Koide, Akiko, Koide, Shohei, Sisodia, Sangram S.   +6 more
openaire   +2 more sources

Muscle Cathepsin B Treatment Improves Behavioral and Neurogenic Deficits in a Mouse Model of Alzheimer's Disease

Aging Cell, Volume 24, Issue 11, November 2025.
Targeting muscle with Cathepsin B (Ctsb) to treat the AD mouse brain. In this study, an AAV‐vector‐mediated approach, utilized to express Ctsb in muscle, prevented mnemonic and neurogenic deficits and normalized hippocampal, muscle, and plasma proteomic profiles.
Alejandro Pinto, Hazal Haytural, Cássio Morais Loss, Claudia Alvarez, Asude Ertas, Olivia Curtis, Alyssa R. Williams, Grayson Murphy, Kenneth J. Salleng, Sylvia Gografe, Nishant P. Visavadiya, Andy V. Khamoui, Ali Altıntaş, Tal Kafri, Romain Barres, Atul S. Deshmukh, Henriette van Praag   +16 more
wiley   +1 more source

Prion protein interacts with bace1 and differentially regulates its activity towards wild type and swedish mutant amyloid precursor protein [PDF]

, 2011
In Alzheimer disease amyloid-β (Aβ) peptides derived from the amyloid precursor protein (APP) accumulate in the brain. Cleavage of APP by the β-secretase BACE1 is the rate-limiting step in the production of Aβ.
Andersen, Anthony J. Turner, Benjannet, Bennett, Bennett, Calella, Capell, Carolyn D. Jackson, Cole, Cole, Creemers, Debbie Brown, Fukumoto, Gimbel, Haass, Haugabook, Heledd H. Griffiths, Herbert Baybutt, Hooper, Huse, Isobel J. Whitehouse, Jean C. Manson, Katherine A.B. Kellett, Kawarabayashi, Kayed, Kayed, Li, Manson, Morrissette, Mucke, Mullan, Murrell, Nigel M. Hooper, Parkin, Pedro Piccardo, Piccardo, Schwarze-Eicker, Selkoe, Spoelgen, Sun, Thinakaran, Vardy, Vassar, Vassar, Walmsley, Walsh, Whitehouse, Yamakawa, Yan, Zhao   +49 more
core   +1 more source

Decoding Glycosylation in Neurodegenerative Diseases: Mechanistic Insights and Therapeutic Opportunities

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
Graphical summary of glycosylation impairments in various neurodegenerative disorders. Among the diverse forms of glycosylation, the most extensively studied include N‐glycosylation, O‐glycosylation, and O‐GlcNAcylation. Aberrant glycosylation has been implicated in multiple neurodegenerative conditions.
Haihan Yu, Xing Chen, Yang Yang, Mengke Gu, Kaidi Ren, Ziqing Wei   +5 more
wiley   +1 more source