Results 61 to 70 of about 6,021 (217)
Alphafuser: a parsimonious approach to predicting higher‐order protein complexes
Acta Crystallographica Section D, Volume 82, Issue 5, Page 421-433, May 2026.Alphafuser is a structure‐prediction pipeline that integrates experimental interaction data with AlphaFold‐based modeling to systematically assemble multiprotein complexes in a computationally efficient manner. By implementing an ipTM‐based pruning algorithm and validating against known structures and experimental assays, Alphafuser enables the ...
Audrey Guillotin +5 more
wiley +1 more source
The role of the Amyloid Precursor Protein mutations and PERK-dependent signaling pathways in the pathogenesis of Alzheimer’s disease [PDF]
, 2016 Alzheimer’s disease (AD) is a highly complex, progressive, age-related neurodegenerative human disease entity. The genetic basis of AD is strictly connected with occurrence of mutations in Amyloid Precursor (APP) gene on chromosome 21.
Diehl, J. Alan +5 more
core +2 more sources
Hair follicle stem cell fate supports distinct clinical endotypes in hidradenitis suppurativa
Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 3, Page 473-483, March 2026.Hair follicles (HFs) were extracted from skin biopsies. From these, original sequencing data were obtained and integrated with two independent studies to build a HF single‐cell transcriptomic atlas. It enabled delineating the fate of HF stem cells.
Audrey Onfroy +17 more
wiley +1 more source
Protein-sphingolipid interactions within cellular membraness⃞
Journal of Lipid Research, 2008 Each intracellular organelle critically depends on maintaining its specific lipid composition that in turn contributes to the biophysical properties of the membrane.
Per Haberkant +8 more
doaj +1 more source
Cancer Cell International, 2020 Background Increasing evidence has proven that the γ-secretase complex plays significant roles in the carcinogenesis of malignancies. However, the independent effect of nicastrin (NCSTN), the largest constituent of the γ-secretase complex, on the ...
Xicheng Wang +6 more
doaj +1 more source
Biomedicines, 2022 Our studies reveal changes in the expression of the main participants in the processing of amyloid precursor protein (APP) in neurons and astrocytes after photothrombotic stroke (PTS). Here we show the increase in the level of N- and C-terminal fragments
Svetlana Sharifulina +10 more
doaj +1 more source
A reporter for amyloid precursor protein γ-secretase activity in Drosophila [PDF]
, 2003 A key event in the pathogenesis of Alzheimer's disease (AD) is the deposition of senile plaques consisting largely of a peptide known as β-amyloid (Aβ) that is derived from the amyloid precursor protein (APP).
Fernandes, Jolene +4 more
core +1 more source
The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells [PDF]
, 2015 INTRODUCTION: The A673T mutation in the amyloid precursor protein (APP) protects against Alzheimer’s disease by reducing β-amyloid protein (Aβ) production.
Asuka Kokawa +6 more
core +1 more source
Akt1 phosphorylates Nicastrin to regulate its protein stability and activity [PDF]
Journal of Neurochemistry, 2015 AbstractThe gamma‐secretase is a multiprotein complex that cleaves many type‐I membrane proteins, such as the Notch receptor and the amyloid precursor protein. Nicastrin (NCT) is an essential component of the multimeric gamma‐secretase complex and functions as a receptor for gamma‐secretase substrates.
Eun-Hye, Jo +9 more
openaire +2 more sources
Advanced Science, Volume 13, Issue 3, 14 January 2026.Alzheimer's disease (AD) is the most common neurodegenerative disorder. This study demonstrates that microglial Rack1 deficiency decreased Aβ deposition and neuroinflammation and ameliorated cognitive impairments in AD model mice by enhancing IGF1‐mediated astrocytic phagocytosis.
Jingdan Zhang +13 more
wiley +1 more source