Super-resolution microscopy reveals γ-secretase at both sides of the neuronal synapse [PDF]
, 2016 The transmembrane protein assembly γ-secretase is a key protease in regulated intramembrane processing (RIP) of around 100 type-1 transmembrane proteins.
Bengt Winblad +4 more
core +1 more source
Glu-333 of Nicastrin Directly Participates in γ-Secretase Activity [PDF]
Journal of Biological Chemistry, 2009 gamma-Secretase is a proteolytic membrane complex that processes a variety of substrates including the amyloid precursor protein and the Notch receptor. Earlier we showed that one of the components of this complex, nicastrin (NCT), functions as a receptor for gamma-secretase substrates.
Daniel R, Dries +6 more
openaire +2 more sources
Serum Immunoglobulin G Levels and Nicastrin Variation in Hidradenitis Suppurativa.
JAMA DermatolImportanceVariation in nicastrin (NCSTN) is associated with a monogenic subtype of hidradenitis suppurativa. Dysregulation of humoral immunity has been suggested as a potential mechanistic link between NCSTN variation and hidradenitis suppurativa. There is a paucity of biomarkers that can predict disease-associated variation.ObjectiveTo investigate ...
Mintoff D, Pace NP.
europepmc +3 more sources
Interactions between APP secretases and inflammatory mediators [PDF]
, 2008 20/11/14 meb. OA paper.
Gentleman, SM, Sastre, M, Walter, J
core +4 more sources
Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity [PDF]
, 2009 L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role in the progression of human carcinoma. Overexpression promotes tumour-cell invasion and motility, growth in nude mice and tumour metastasis.
Riedle, Svenja +6 more
core +2 more sources
The Large Ectodomain of APP Prevents APP from being Directly Cleaved by γ-Secretase
Frontiers in Bioscience-LandmarkBackground: Alzheimer’s disease (AD) is characterized by the deposition of amyloid-β peptide (Aβ) in the brain. Aβ is produced by sequential β- and γ-secretase cleavages of amyloid precursor protein (APP).
Yuan Li +4 more
doaj +1 more source
Frontiers in Chemistry, 2019 γ-secretase, an intramembrane-cleaving aspartyl protease is involved in the cleavage of a large number of intramembrane proteins. The most prominent substrate is the amyloid precursor protein, whose proteolytic processing leads to the production of ...
Manuel Hitzenberger, Martin Zacharias
doaj +1 more source
Transcriptional regulation of PEN-2, a key component of the γ-secretase complex, by CREB [PDF]
, 2006 Gamma-secretase, which is responsible for the intramembranous cleavage of Alzheimer's P-amyloid precursor protein (APP), the signaling receptor Notch, and many other substrates, is a multiprotein complex consisting of at least four components: presenilin
Ruishan Wang +11 more
core +2 more sources
Loss of Notch signaling in skeletal stem cells enhances bone formation with aging
Bone Research, 2023 Skeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age, they produce fewer osteoblasts and more adipocytes leading to a loss of skeletal integrity.
Lindsey H. Remark +18 more
doaj +1 more source
Characterization of the γ-secretase subunit interactome in Arabidopsis thaliana [PDF]
, 2019 Gamma secretase is a multi-subunit complex with aspartic intramembrane protease activity that is involved in the pathogenesis of Alzheimer's disease in humans. In Arabidopsis thaliana, -secretase subunits are localized to endomembrane system compartments
De Jaeger, Geert +7 more
core +1 more source