Results 31 to 40 of about 6,021 (217)
The Biochemical and Genetic Odyssey to the Function of a Nicastrin-Like Protein [PDF]
, 2004 gamma-Secretase is a high-molecular-weight protein complex required for the proteolytic processing of various transmembrane proteins including the Alzheimer's disease-associated amyloid precursor protein and the signaling receptor Notch. One of the gamma-
Haass, Christian, Haffner, Christof
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Molecular Metabolism, 2016 Objective: As the obesity pandemic continues to expand, novel molecular targets to reduce obesity-related insulin resistance and Type 2 Diabetes (T2D) continue to be needed.
David P. Sparling +6 more
doaj +1 more source
DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation [PDF]
, 2015 The acquisition of endocrine therapy resistance in estrogen receptor a (ERa) breast cancer patients represents a major clinical problem. Notch signalling has been extensively linked to breast cancer especially in patients who fail to respond to endocrine
Aifantis +54 more
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Structure of nicastrin unveils secrets of γ-secretase [PDF]
Proceedings of the National Academy of Sciences, 2014 Despite afflicting tens of millions worldwide, Alzheimer’s disease (AD) remains a devastating brain-destroying malady with no effective treatment or cure. A central hallmark of AD is the deposition of amyloid plaques in the brain. These plaques are primarily composed of the amyloid β-peptide (Aβ), a byproduct of proteolytic processing of the amyloid ...
David M, Bolduc, Michael S, Wolfe
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A Role for Presenilin 1 in Regulating the Delivery of Amyloid Precursor Protein to the Cell Surface
Neurobiology of Disease, 2002 Presenilin 1 (PS1) and presenilin 2 play a critical role in the γ-secretase processing of amyloid precursor protein (APP) and Notch1. Here, we investigate maturation and intracellular trafficking of APP and other membrane proteins in cells expressing an ...
Jae Yoon Leem +13 more
doaj +1 more source
Assembly, trafficking and function of gamma-secretase [PDF]
, 2006 gamma-Secretase catalyzes the final cleavage of the beta-amyloid precursor protein to generate amyloid-beta peptide, the principal component of amyloid plaques in the brains of patients suffering from Alzheimer's disease.
Baumeister R +9 more
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Nicastrin: Gatekeeper of the γ-Secretase Complex [PDF]
Cell, 2005 The gamma-secretase intramembrane protease cleaves many type I membrane proteins including amyloid precursor protein and Notch, generating peptide fragments that are important signaling components. In this issue of Cell, Shah et al. (2005) reveal the function of nicastrin, the largest member of the gamma-secretase complex.
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Association of active γ-secretase complex with lipid rafts
Journal of Lipid Research, 2005 Cholesterol has been implicated in the pathogenesis of Alzheimer's disease (AD). Although the underlying mechanisms are not yet clear, several studies have provided evidence for the involvement of cholesterol-rich lipid rafts in the production of amyloid
Yasuomi Urano +9 more
doaj +1 more source
Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction [PDF]
, 2010 Synaptic dysfunction is widely thought to be a pathogenic precursor to neurodegeneration in Alzheimer’s disease (AD), and the extent of synaptic loss provides the best correlate for the severity of dementia in AD patients.
Ho, Angela +5 more
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Tau, APP, NCT and BACE1 in lymphocytes through cognitively normal ageing and neuropathology
Anais da Academia Brasileira de Ciências, 2013 Although Alzheimer's disease is a brain disorder, a number of peripheral alterations have been found in these patients; however, little is known about how the key genes involved in the pathophysiology express in peripheral cells such as lymphocytes ...
MARISOL HERRERA-RIVERO +3 more
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