Cellular functions of gamma-secretase-related proteins [PDF]
, 2006 Amyloid-beta pepticle (A beta) is generated by gamma-secretase, a membrane protein complex with an unusual aspartyl protease activity consisting of the four components presenilin, nicastrin, APH-1 and PEN-2. Presenilin is considered the catalytic subunit
Haass, Christian, Haffner, Christof
core +1 more source
Nicastrin Deficiency Induces Tyrosinase-Dependent Depigmentation and Skin Inflammation [PDF]
Journal of Investigative Dermatology, 2020 Skin depigmentation diseases, such as vitiligo, are pigmentation disorders that often destroy melanocytes. However, their pathological mechanisms remain unclear, and therefore, promising treatments or prevention has been lacking. Here, we demonstrate that a zebrafish insertional mutant showing a significant reduction of nicastrin transcript possesses ...
Chia-Hao Hsu +2 more
openaire +2 more sources
Village guards as “in between” in the Turkish-Kurdish conflict: Re-examining identity and position in intergroup conflict [PDF]
, 2019 The current paper utilizes new approaches in intergroup conflict studies to examine the village guard system and its role in the Turkish-Kurdish conflict in Turkey.
Acar, Yasemin Gülsüm
core +3 more sources
Nicastrin guards Alzheimer’s gate [PDF]
Proceedings of the National Academy of Sciences, 2016 Alzheimer’s disease is characterized by protein deposits of amyloid-β as plaques in the brain (1). The suite of enzymes that produce amyloid-β by cutting it out of the amyloid-β precursor protein (APP) have long been considered to be prime targets for therapeutic intervention.
openaire +2 more sources
Crystal structure of the γ-secretase component nicastrin [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance γ-Secretase is a four-component intramembrane protease associated with the onset of Alzheimer's disease. Nicastrin is the putative substrate-recruiting component of the γ-secretase complex, but no atomic-resolution structure had been identified on γ-secretase or any of its four components.
Tian, Xie +8 more
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Nicastrin and Notch4 drive endocrine therapy resistance and epithelial to mesenchymal transition in MCF7 breast cancer cells [PDF]
, 2014 Introduction Resistance to anti-estrogen therapies is a major cause of disease relapse and mortality in estrogen receptor alpha (ERα)-positive breast cancers.
Coombes, RC +5 more
core +3 more sources
MicroRNAs targeting Nicastrin regulate Aβ production and are affected by target site polymorphisms
Frontiers in Molecular Neuroscience, 2014 Despite the growing number of genome-wide association studies, the involvement of polymorphisms in microRNA target sites (polymiRTS) in Alzheimer’s disease (AD) remains poorly investigated.
Charlotte eDelay +10 more
doaj +1 more source
Signal peptide peptidases and gamma-secretase: Cousins of the same protease family? [PDF]
, 2007 Signal peptide peptidase (SPIP) is an unusual aspartyl protease, which mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER).
Christian Haass +15 more
core +2 more sources
The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]
, 2015 Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S. +3 more
core +1 more source
Neuartige Variante des NCSTN‐Gens bei einer Frau mit familiärer Hidradenitis suppurativa [PDF]
J Dtsch Dermatol GesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 10, Page 1332-1334, October 2025.
Hempel C +6 more
europepmc +2 more sources