Results 11 to 20 of about 6,021 (217)
The Nicastrin ectodomain adopts a highly thermostable structure [PDF]
bchm, 2011 Nicastrin is a type I transmembrane glycoprotein, which is part of the high molecular weight gamma-secretase complex. gamma-Secretase is one of the key players associated with the generation of Alzheimer's disease pathology, since it liberates the ...
Beyer, Klaus +6 more
core +7 more sources
The Notch inhibitor cowanin accelerates nicastrin degradation [PDF]
Scientific Reports, 2018 Aberrant activation of Notch signaling contributes to the pathogenesis of several different types of cancer, and Notch pathway inhibitors may have significant therapeutic potential.
Midori A. Arai +6 more
doaj +3 more sources
Novel variant of the NCSTN gene identified in a woman with hidradenitis suppurativa. [PDF]
J Dtsch Dermatol GesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 10, Page 1332-1334, October 2025.
Hempel C +6 more
europepmc +2 more sources
Transcript-Level Modulation of O-GlcNAc Transferase for Aging-Related Neurodegenerative Diseases. [PDF]
ChembiochemO‐GlcNAc Transferase (OGT) and O‐GlcNAcase (OGA) maintain O‐GlcNAc homeostasis, but OGT expression and activity decline in the aging brain, promoting protein aggregation and neurodegeneration. Current approaches raise O‐GlcNAc levels via OGA inhibition. New insights into OGT splicing enable direct OGT upregulation using ASO‐ or PROTAC‐based strategies,
Malard F.
europepmc +2 more sources
Membralin Assembles a MAN1B1-VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation. [PDF]
Adv Sci (Weinh)This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Zhang J +5 more
europepmc +2 more sources
Rare missense variants in the SH3 domain of PSTPIP1 are associated with hidradenitis suppurativa
HGG Advances, 2023 Summary: Hidradenitis suppurativa (HS) is a chronic, debilitating skin disease for which few treatment options are available. While most HS is sporadic, some rare kindred show a high-penetrance, autosomal-dominant inheritance.
David J. Morales-Heil +11 more
doaj +1 more source
Synaptic function of nicastrin in hippocampal neurons [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance Mutations in the presenilin genes are the major cause of familial forms of Alzheimer’s disease. Nicastrin and presenilin are essential components of the γ-secretase complex, an intramembrane protease that cleaves type I membrane proteins such as Notch and the amyloid precursor protein ...
Sang Hun, Lee +3 more
openaire +2 more sources
Neurobiology of Disease, 2007 Nicastrin is an integral member of PS-complexes that perform γ-secretase cleavage of numerous type I membrane proteins including amyloid precursor protein that underlies Alzheimer's disease; thus, diminishing γ-secretase activity by reducing levels of ...
Sonya Brijbassi +5 more
doaj +1 more source
Biomedicines, 2021 Triple negative breast cancer (TNBC) is observed in ~15% of breast cancers and results in poor survival and increased distant metastases. Within the tumor are present a small portion of cancer stem cells that drive tumorigenesis and metastasis.
Prabhu Ramamoorthy +3 more
doaj +1 more source
Microorganisms, 2021 Nicastrin (NICT) is a transmembrane protein physically associated with the polytypical aspartyl protease presenilin that plays a vital role in the correct localization and stabilization of presenilin to the membrane-bound γ-secretase complex.
Guilherme Curty Lechuga +5 more
doaj +1 more source