Results 41 to 50 of about 6,021 (217)
Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin [PDF]
, 2010 γ-secretase is a multiprotein intramembrane-cleaving protease with a growing list of protein substrates including the Notch receptors and the amyloid precursor protein.
Ilagan, Ma. Xenia G +3 more
core +2 more sources
Frontiers in Immunology, 2018 Background: The pathogenesis of hidradenitis suppurativa (HS) is not fully understood. This systematic review examined the latest evidence for molecular inflammatory pathways involved in HS as a chronic inflammatory skin disease.Methods: A systematic ...
Allard R. J. V. Vossen +2 more
doaj +1 more source
Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo. [PDF]
PLoS ONE, 2011 Increase in the generation and deposition of amyloid-β (Aβ) plays a central role in the development of Alzheimer's Disease (AD). Elevation of the activity of γ-secretase, a key enzyme required for the generation for Aβ, can thus be a potential risk ...
Tong Li +5 more
doaj +1 more source
The very many faces of presenilins and the γ-secretase complex [PDF]
, 2013 Presenilin is a central, catalytic component of the γ-secretase complex which conducts intramembrane cleavage of various protein substrates. Although identified and mainly studied through its role in the development of amyloid plaques in Alzheimer ...
Michalina Smolarkiewicz +2 more
core +1 more source
Frontiers in Medicine, 2019 Background: Familial Hidradenitis Suppurativa and Familial Alzheimer's Disease are both associated with Gamma-Secretase Complex mutations; however, the two diseases are not epidemiologically associated. Understanding the molecular differences between the
John W. Frew +2 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2018 Alzheimer’s disease (AD) is a neurodegenerative disease characterized by cognitive impairment. The neuropathological features of AD are the aggregation of extracellular amyloid β-protein (Aβ) and tau phosphorylation.
Xin Yu +6 more
doaj +1 more source
Cells, 2023 Maternal overnutrition has been reported to affect brain plasticity of the offspring by altering gene expression, regulating both synaptic plasticity and adult neurogenesis.
Francesca Natale +6 more
doaj +1 more source
Different types of γ-secretes complexes and their effect on substrate processing [PDF]
, 2012 The γ-secretase complex is a transmembrane aspartyl protease that generates the Alzheimer disease (AD) related amyloid β-peptide (Aβ) from the amyloid precursor protein (APP). The γ- secretase complex cleaves APP at two different sites (γ- and ε-sites)
Pamrén, Annelie
core +1 more source
The γ-secretase complex: from structure to function
Frontiers in Cellular Neuroscience, 2014 One of the most critical pathological features of Alzheimer’s disease (AD) is the accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain. Aβ is derived from β-amyloid precursor protein through sequential cleavage by β-
Xian eZhang +4 more
doaj +1 more source
Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements [PDF]
, 2011 The presenilin/γ-secretase complex, an unusual intramembrane aspartyl protease, plays an essential role in cellular signaling and membrane protein turnover.
Elias, Joshua E +3 more
core +1 more source