Results 161 to 170 of about 3,289 (188)

Chemerin-9 is neuroprotective in APP/PS1 transgenic mice by inhibiting NLRP3 inflammasome and promoting microglial clearance of Aβ. [PDF]

J Neuroinflammation
Zhang J, Zhang Y, Liu L, Zhang M, Zhang X, Deng J, Zhao F, Lin Q, Zheng X, Fu B, Zhao Y, Wang X.   +11 more
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Hidradenitis secondary to nirogacestat, a recently approved desmoid tumor medication. [PDF]

JAAD Case Rep
Frantz TC, Kirwin D, Brahe C.
europepmc   +1 more source

Comprehensive Catalog of Variants Potentially Associated with Hidradenitis Suppurativa, Including Newly Identified Variants from a Cohort of 100 Patients. [PDF]

Int J Mol Sci
Muret K, Le Goff V, Dandine-Roulland C, Hotz C, Jean-Louis F, Boisson B, Mesrob L, Sandron F, Daian D, Olaso R, Le Floch E, Meyer V, Wolkenstein P, Casanova JL, Lévy Y, Bonnet E, Deleuze JF, Hüe S.   +17 more
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BACE1 interacts with nicastrin

Biochemical and Biophysical Research Communications, 2002
Beta-amyloid peptide (Abeta) is generated through the proteolytic cleavage of beta-amyloid precursor protein (APP) by beta- and gamma-secretases. The beta-secretase, BACE1, initiates Abeta formation followed by gamma-cleavage within the APP transmembrane domain.
Chinatsu, Hattori, Masashi, Asai, Yoko, Oma, Yoshihiro, Kino, Noboru, Sasagawa, Takaomi C, Saido, Kei, Maruyama, Shoichi, Ishiura   +7 more
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Nicastrin binds to membrane-tethered Notch

Nature Cell Biology, 2001
The presenilins and nicastrin, a type 1 transmembrane glycoprotein, form high molecular weight complexes that are involved in cleaving the beta-amyloid precursor protein (betaAPP) and Notch in their transmembrane domains. The former process (termed gamma-secretase cleavage) generates amyloid beta-peptide (Abeta), which is involved in the pathogenesis ...
Yu, G, Lee, J, St GeorgeHyslop, PH, Janus, C, Yu, C, Sato, C, Milman, P, Song, L, Rogaeva, E, Song, YQ, Supala, A, Fraser, PE, Zhang, L, Chen, F, Tandon, A, Yu, H, Kawarai, T, Nishimura, M, Arawaka, S   +18 more
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Nicastrin gene in familial and sporadic Alzheimer's disease

Neuroscience Letters, 2003
Nicastrin is a protein recently discovered associated to presenilins and involved in the production of amyloid beta peptide that accumulates in Alzheimer's disease (AD) brain. In this study the nicastrin gene was examined for unknown mutations and polymorphisms in 104 patients with familial AD (52 early-onset and 52 late-onset), 174 sporadic AD and 191
CONFALONI A, TERRENI L, PISCOPO P, CRESTINI A, CAMPEGGI LM, FRIGERIO CS, BLOTTA I, PERRI M, DI NATALE M, MALETTA R, MARCON, Gabriella, FRANCESCHI M, BRUNI AC, FORLONI G, CANTAFORA A.   +14 more
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Overexpression of nicastrin increases Aß production

The FASEB Journal, 2003
ABSTRACT γ‐Secretase cleavage is the final proteolytic step that releases the amyloid β‐peptide (Aβ) from the amyloid β‐protein precursor (APP). Significant evidence indicates that the presenilins (PS) are catalytic components of a high molecular weight γ‐secretase complex.
M Paul, Murphy, Pritam, Das, Andrew C, Nyborg, Marjorie J, Rochette, Mark W, Dodson, Nicole M, Loosbrock, Terrance M, Souder, Chris, McLendon, Sami L, Merit, Siân C, Piper, Karen R, Jansen, Todd E, Golde   +11 more
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Nicastrin is a resident lysosomal membrane protein

Biochemical and Biophysical Research Communications, 2003
Nicastrin has been recently identified as part of the gamma-secretase complex that includes presenilin and other proteins. It is involved in the degradation of amyloid precursor protein to produce beta-amyloid peptides which are believed to be central to the pathophysiology of Alzheimer's disease.
Richard D, Bagshaw, Stephen H, Pasternak, Don J, Mahuran, John W, Callahan   +3 more
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Neprilysin activity and expression are controlled by nicastrin

Journal of Neurochemistry, 2006
AbstractWe recently demonstrated that the presenilin‐dependent γ‐secretase complex regulates the expression and activity of neprilysin, one of the main enzymes that degrade the amyloid β‐peptide (Aβ) which accumulates in Alzheimer's disease. Here, we examined the influence of endogenous nicastrin (NCT), a member of the γ‐secretase complex, on ...
R, Pardossi-Piquard, J, Dunys, G, Yu, P, St George-Hyslop, C, Alves da Costa, F, Checler   +5 more
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