Results 181 to 190 of about 6,021 (217)

Overexpression of nicastrin increases Aß production

The FASEB Journal, 2003
ABSTRACT γ‐Secretase cleavage is the final proteolytic step that releases the amyloid β‐peptide (Aβ) from the amyloid β‐protein precursor (APP). Significant evidence indicates that the presenilins (PS) are catalytic components of a high molecular weight γ‐secretase complex.
M Paul, Murphy, Pritam, Das, Andrew C, Nyborg, Marjorie J, Rochette, Mark W, Dodson, Nicole M, Loosbrock, Terrance M, Souder, Chris, McLendon, Sami L, Merit, Siân C, Piper, Karen R, Jansen, Todd E, Golde   +11 more
openaire   +2 more sources

Immature nicastrin stabilizes APH‐1 independent of PEN‐2 and presenilin: identification of nicastrin mutants that selectively interact with APH‐1 [PDF]

Journal of Neurochemistry, 2004
Abstractγ‐Secretase is a high molecular mass aspartyl protease complex composed of presenilin (PS1 or PS2), nicastrin (Nct), anterior pharynx‐defective‐1 (APH‐1) and presenilin enhancer‐2 (PEN‐2). The complex mediates the intramembraneous proteolysis of β‐secretase cleaved β‐amyloid precursor protein (APP) leading to the secretion of the Alzheimer's ...
Dieter Edbauer, Harald Steiner
exaly   +3 more sources

Neprilysin activity and expression are controlled by nicastrin

Journal of Neurochemistry, 2006
AbstractWe recently demonstrated that the presenilin‐dependent γ‐secretase complex regulates the expression and activity of neprilysin, one of the main enzymes that degrade the amyloid β‐peptide (Aβ) which accumulates in Alzheimer's disease. Here, we examined the influence of endogenous nicastrin (NCT), a member of the γ‐secretase complex, on ...
R, Pardossi-Piquard, J, Dunys, G, Yu, P, St George-Hyslop, C, Alves da Costa, F, Checler   +5 more
openaire   +2 more sources

Degradation of nicastrin involves both proteasome and lysosome

Journal of Neurochemistry, 2007
AbstractThe glycoprotein nicastrin (NCT) is an essential component of the γ‐secretase complex, a high molecular weight complex which also contains the presenilin proteins, Aph‐1 and Pen‐2. The γ‐secretase complex is not only involved in APP processing but also in the processing of an increasing number of other type I integral membrane proteins.
Guiqiong, He, Hong, Qing, Yigang, Tong, Fang, Cai, Shoichi, Ishiura, Weihong, Song   +5 more
openaire   +2 more sources

Nicastrin — Protein mit Scharnierfunktion

Pharmazie in unserer Zeit, 2003
AbstractMit über 70 Prozent ist die Alzheimer‐Erkrankung die weitaus häufigste Form einer Demenz. Charakteristisch im histologischen Bild sind dabei Ablagerungen kleiner klebriger Amyloid‐Moleküle im Gehirn. Noch liegt der Pathomechanismus der Alzheimer‐Demenz weitgehend im Dunklen. Jetzt sind Biochemiker der LMU München am Lehrstuhl von Prof.
openaire   +1 more source

Nicastrin gene polymorphisms, cognitive ability level and cognitive ageing

Neuroscience Letters, 2005
The hypothesis that polymorphisms in the gene for nicastrin (NCSTN) are associated with differences in cognitive level and ageing was tested in 462 relatively healthy surviving participants of the Scottish Mental Survey 1932. None had a history of dementia.
Deary, I J, Hamilton, G, Hayward, C, Whalley, L J, Powell, J, Starr, J M, Lovestone, S   +6 more
openaire   +4 more sources

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

Nature Cell Biology, 2001
The transmembrane glycoprotein Nicastrin was identified in a complex with the multipass membrane protein Presenilin. Presenilin mediates transmembrane cleavage of single-pass transmembrane proteins with short extracellular domains, including the ligand-activated form of the receptor Notch and beta-amyloid precursor protein (beta-APP).
Gary Struhl
exaly   +3 more sources

Drosophila Nicastrin Is Essential for the Intramembranous Cleavage of Notch [PDF]

Developmental Cell, 2002
The catalytic subunit of gamma-secretase is thought to be Presenilin, which is required for both the cleavage of APP and in the processing of Notch. Presenilin is found in a multisubunit complex that also contains Nicastrin. Nicastrin has been implicated in APP processing, but its role in Notch signaling remains unclear.
Hernán López-Schier, Daniel St Johnston   +1 more
exaly   +3 more sources

Testing Specificity of Commercially Available Nicastrin Antibodies

The FASEB Journal, 2016
A protein complex known as γ‐secretase is involved in the development of Alzheimer's disease, which affects cognitive functions such as learning and memory. Nicastrin, a component of γ‐secretase, is the substrate receptor in the protein complex.
Jessica Hatter, Daniel Dries
openaire   +1 more source

Analysis of nicastrin gene phylogeny and expression in zebrafish

Development Genes and Evolution, 2015
NICASTRIN is a component of the aspartyl protease γ-secretase complex which is involved in intramembranous cleavage of type I transmembrane proteins, notably the Notch receptor proteins and the AMYLOID BETA A4 PRECURSOR PROTEIN (APP). This study aimed to characterize the orthologue of the human NICASTRIN (NCSTN) gene in zebrafish, an advantageous model
Lim, A., Moussavi Nik, S., Ebrahimie, E., Lardelli, M.   +3 more
openaire   +3 more sources