Results 191 to 200 of about 6,021 (217)

Association analysis between Alzheimer's disease and the Nicastrin gene polymorphisms

Neuroscience Letters, 2002
The biological study of the Nicastrin protein shows its crucial role in the pathogenesis of Alzheimer's disease (AD). We tested the hypothesis that the Nicastrin (NCSTN) gene might be genetically associated with AD. The association analysis of two single nucleotide polymorphisms (SNPs) in the coding region (cSNPs) of NCSTN were performed in an Italian ...
ORLACCHIO, ANTONIO, Kawarai, T, Polidoro, M, STEFANI, ALESSANDRO, Orlacchio, A, St George Hyslop, P, BERNARDI, GIORGIO   +6 more
openaire   +3 more sources

Further Analysis of the Nicastrin: Presenilin Complex

2002
Nicastrin (Yu et al. 2000) and the presenilins (Rogaev et al. 1995; Sherrington et al. 1995) form high molecular weight complexes that are involved in the cleavage of the β-amyloid precursor protein (βAPP; Citron et al. 1997; De Strooper et al. 1998; Wolfe et al. 1999; Li et al. 2000; Yu et al.
F. Chen, G. Yu, S. Arawaka, M. Nishimura, T. Kawarai, H. Yu, A. Tandon, A. Supala, Y. Q. Song, E. Rogaeva, P. Milman, Ch. Sato, Ch. Janus, J. Lee, L. Song, L. Zhang, P. E. Fraser, P. H. St George-Hyslop   +17 more
openaire   +1 more source

Loss of nicastrin elicits an apoptotic phenotype in mouse embryos

Brain Research, 2006
Nicastrin is a member of the high molecular weight presenilin complex that plays a central role in gamma-secretase cleavage of numerous type-1 membrane-associated proteins required for cell signaling, proliferation and lineage development. We have generated a nicastrin-null mouse line by disruption of exon 3.
Van, Nguyen, Cynthia, Hawkins, Catherine, Bergeron, Agnes, Supala, Jean, Huang, David, Westaway, Peter, St George-Hyslop, Richard, Rozmahel   +7 more
openaire   +2 more sources

ER-stress-inducible Herp, facilitates the degradation of immature nicastrin

Biochimica et Biophysica Acta (BBA) - General Subjects, 2011
Herp is an endoplasmic reticulum (ER)-stress-inducible membrane protein harboring an ubiquitin-like domain (ULD). However, its biological functions are not fully understood. Here, we examined the role of Herp in the degradation of γ-secretase components.Effects of ULD-lacking Herp (ΔUb-Herp) expression on the degradation of γ-secretase components were ...
Toshihiro, Marutani, Tomoji, Maeda, Chiaki, Tanabe, Kun, Zou, Wataru, Araki, Koichi, Kokame, Makoto, Michikawa, Hiroto, Komano   +7 more
openaire   +2 more sources

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing

Nature, 2000
Shigeki Arawaka, Anurag Tandon, You-Qiang Song   +2 more
exaly  

Die Rolle von Nicastrin in der Pigmentierung

2022
openaire   +1 more source

The presenilin C-terminus is required for ER-retention, nicastrin-binding and γ-secretase activity

EMBO Journal, 2004
Christoph Kaether, Anja Capell, Dieter Edbauer   +2 more
exaly  

Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex

Neuron, 2003
Bart De Strooper
exaly  

P2‐314: Molecular studies of nicastrin in the γ‐Secretase complex using an artificial nicastrin independent presenilin 1 double mutant

Alzheimer's & Dementia, 2011
Annelie Svensson, Johanna Wanngren, Patricia Lara Vasquez, Karin Geiger, IngMarie Nilsson, Helena Karlström   +5 more
openaire   +1 more source

The levels of mature glycosylated nicastrin are regulated and correlate with γ-secretase processing of amyloid β-precursor protein

Journal of Neurochemistry, 2002
Shigeki Arawaka, Anurag Tandon, Peter H St George-Hyslop   +2 more
exaly