Results 171 to 180 of about 6,021 (217)

In Silico Phosphoproteomic Analysis Reveals Divergent Regulation of Presenilin 1 and Presenilin 2. [PDF]

Neuromolecular Med
Begum S, De Alvarez JA, Manzoni C, Arber C, Lewis PA.   +4 more
europepmc   +1 more source

Hidradenitis secondary to nirogacestat, a recently approved desmoid tumor medication. [PDF]

JAAD Case Rep
Frantz TC, Kirwin D, Brahe C.
europepmc   +1 more source

Glycosylation in neuroinflammation: mechanisms, implications, and therapeutic strategies for neurodegenerative diseases. [PDF]

Transl Neurodegener
Cheng S, Xiao B, Luo Z.
europepmc   +1 more source

Chemerin-9 is neuroprotective in APP/PS1 transgenic mice by inhibiting NLRP3 inflammasome and promoting microglial clearance of Aβ. [PDF]

J Neuroinflammation
Zhang J, Zhang Y, Liu L, Zhang M, Zhang X, Deng J, Zhao F, Lin Q, Zheng X, Fu B, Zhao Y, Wang X.   +11 more
europepmc   +1 more source

Nicastrin Functions as a γ-Secretase-Substrate Receptor [PDF]

Cell, 2005
gamma-secretase catalyzes the intramembrane cleavage of amyloid precursor protein (APP) and Notch after their extracellular domains are shed by site-specific proteolysis. Nicastrin is an essential glycoprotein component of the gamma-secretase complex but has no known function.
Katsuhiko Tabuchi
exaly   +3 more sources

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Nicastrin binds to membrane-tethered Notch

Nature Cell Biology, 2001
The presenilins and nicastrin, a type 1 transmembrane glycoprotein, form high molecular weight complexes that are involved in cleaving the beta-amyloid precursor protein (betaAPP) and Notch in their transmembrane domains. The former process (termed gamma-secretase cleavage) generates amyloid beta-peptide (Abeta), which is involved in the pathogenesis ...
Shigeki Arawaka, Anurag Tandon, Ekaterina Rogaeva   +2 more
exaly   +5 more sources

Nicastrin is a resident lysosomal membrane protein

Biochemical and Biophysical Research Communications, 2003
Nicastrin has been recently identified as part of the gamma-secretase complex that includes presenilin and other proteins. It is involved in the degradation of amyloid precursor protein to produce beta-amyloid peptides which are believed to be central to the pathophysiology of Alzheimer's disease.
Richard D Bagshaw, Stephen H Pasternak
exaly   +3 more sources

BACE1 interacts with nicastrin

Biochemical and Biophysical Research Communications, 2002
Beta-amyloid peptide (Abeta) is generated through the proteolytic cleavage of beta-amyloid precursor protein (APP) by beta- and gamma-secretases. The beta-secretase, BACE1, initiates Abeta formation followed by gamma-cleavage within the APP transmembrane domain.
Chinatsu, Hattori, Masashi, Asai, Yoko, Oma, Yoshihiro, Kino, Noboru, Sasagawa, Takaomi C, Saido, Kei, Maruyama, Shoichi, Ishiura   +7 more
openaire   +2 more sources

Nicastrin gene in familial and sporadic Alzheimer's disease

Neuroscience Letters, 2003
Nicastrin is a protein recently discovered associated to presenilins and involved in the production of amyloid beta peptide that accumulates in Alzheimer's disease (AD) brain. In this study the nicastrin gene was examined for unknown mutations and polymorphisms in 104 patients with familial AD (52 early-onset and 52 late-onset), 174 sporadic AD and 191
CONFALONI A, TERRENI L, PISCOPO P, CRESTINI A, CAMPEGGI LM, FRIGERIO CS, BLOTTA I, PERRI M, DI NATALE M, MALETTA R, MARCON, Gabriella, FRANCESCHI M, BRUNI AC, FORLONI G, CANTAFORA A.   +14 more
openaire   +5 more sources