Results 171 to 180 of about 3,289 (188)

Degradation of nicastrin involves both proteasome and lysosome

Journal of Neurochemistry, 2007
AbstractThe glycoprotein nicastrin (NCT) is an essential component of the γ‐secretase complex, a high molecular weight complex which also contains the presenilin proteins, Aph‐1 and Pen‐2. The γ‐secretase complex is not only involved in APP processing but also in the processing of an increasing number of other type I integral membrane proteins.
Guiqiong, He, Hong, Qing, Yigang, Tong, Fang, Cai, Shoichi, Ishiura, Weihong, Song   +5 more
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Nicastrin — Protein mit Scharnierfunktion

Pharmazie in unserer Zeit, 2003
AbstractMit über 70 Prozent ist die Alzheimer‐Erkrankung die weitaus häufigste Form einer Demenz. Charakteristisch im histologischen Bild sind dabei Ablagerungen kleiner klebriger Amyloid‐Moleküle im Gehirn. Noch liegt der Pathomechanismus der Alzheimer‐Demenz weitgehend im Dunklen. Jetzt sind Biochemiker der LMU München am Lehrstuhl von Prof.
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Nicastrin gene polymorphisms, cognitive ability level and cognitive ageing

Neuroscience Letters, 2005
The hypothesis that polymorphisms in the gene for nicastrin (NCSTN) are associated with differences in cognitive level and ageing was tested in 462 relatively healthy surviving participants of the Scottish Mental Survey 1932. None had a history of dementia.
Deary, I J, Hamilton, G, Hayward, C, Whalley, L J, Powell, J, Starr, J M, Lovestone, S   +6 more
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Testing Specificity of Commercially Available Nicastrin Antibodies

The FASEB Journal, 2016
A protein complex known as γ‐secretase is involved in the development of Alzheimer's disease, which affects cognitive functions such as learning and memory. Nicastrin, a component of γ‐secretase, is the substrate receptor in the protein complex.
Jessica Hatter, Daniel Dries
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Analysis of nicastrin gene phylogeny and expression in zebrafish

Development Genes and Evolution, 2015
NICASTRIN is a component of the aspartyl protease γ-secretase complex which is involved in intramembranous cleavage of type I transmembrane proteins, notably the Notch receptor proteins and the AMYLOID BETA A4 PRECURSOR PROTEIN (APP). This study aimed to characterize the orthologue of the human NICASTRIN (NCSTN) gene in zebrafish, an advantageous model
Lim, A., Moussavi Nik, S., Ebrahimie, E., Lardelli, M.   +3 more
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Association analysis between Alzheimer's disease and the Nicastrin gene polymorphisms

Neuroscience Letters, 2002
The biological study of the Nicastrin protein shows its crucial role in the pathogenesis of Alzheimer's disease (AD). We tested the hypothesis that the Nicastrin (NCSTN) gene might be genetically associated with AD. The association analysis of two single nucleotide polymorphisms (SNPs) in the coding region (cSNPs) of NCSTN were performed in an Italian ...
ORLACCHIO, ANTONIO, Kawarai, T, Polidoro, M, STEFANI, ALESSANDRO, Orlacchio, A, St George Hyslop, P, BERNARDI, GIORGIO   +6 more
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Further Analysis of the Nicastrin: Presenilin Complex

2002
Nicastrin (Yu et al. 2000) and the presenilins (Rogaev et al. 1995; Sherrington et al. 1995) form high molecular weight complexes that are involved in the cleavage of the β-amyloid precursor protein (βAPP; Citron et al. 1997; De Strooper et al. 1998; Wolfe et al. 1999; Li et al. 2000; Yu et al.
F. Chen, G. Yu, S. Arawaka, M. Nishimura, T. Kawarai, H. Yu, A. Tandon, A. Supala, Y. Q. Song, E. Rogaeva, P. Milman, Ch. Sato, Ch. Janus, J. Lee, L. Song, L. Zhang, P. E. Fraser, P. H. St George-Hyslop   +17 more
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Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

Nature Cell Biology, 2001
The transmembrane glycoprotein Nicastrin was identified in a complex with the multipass membrane protein Presenilin. Presenilin mediates transmembrane cleavage of single-pass transmembrane proteins with short extracellular domains, including the ligand-activated form of the receptor Notch and beta-amyloid precursor protein (beta-APP).
H M, Chung, G, Struhl
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Loss of nicastrin elicits an apoptotic phenotype in mouse embryos

Brain Research, 2006
Nicastrin is a member of the high molecular weight presenilin complex that plays a central role in gamma-secretase cleavage of numerous type-1 membrane-associated proteins required for cell signaling, proliferation and lineage development. We have generated a nicastrin-null mouse line by disruption of exon 3.
Van, Nguyen, Cynthia, Hawkins, Catherine, Bergeron, Agnes, Supala, Jean, Huang, David, Westaway, Peter, St George-Hyslop, Richard, Rozmahel   +7 more
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ER-stress-inducible Herp, facilitates the degradation of immature nicastrin

Biochimica et Biophysica Acta (BBA) - General Subjects, 2011
Herp is an endoplasmic reticulum (ER)-stress-inducible membrane protein harboring an ubiquitin-like domain (ULD). However, its biological functions are not fully understood. Here, we examined the role of Herp in the degradation of γ-secretase components.Effects of ULD-lacking Herp (ΔUb-Herp) expression on the degradation of γ-secretase components were ...
Toshihiro, Marutani, Tomoji, Maeda, Chiaki, Tanabe, Kun, Zou, Wataru, Araki, Koichi, Kokame, Makoto, Michikawa, Hiroto, Komano   +7 more
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