Results 111 to 120 of about 8,705 (221)
Cellular Physiology and Biochemistry, 2018 Background/Aims: As the most lethal urological cancers, renal cell carcinoma (RCC) comprises a heterogeneous group of cancer with diverse genetic and molecular alterations. There is an unmet clinical need to develop efficacious therapeutics for advanced,
Xinyi Yu +32 more
doaj +1 more source
, 2014 Failure to control clinical worm infestation in sheep can result in blood loss, thin animals and death. In case of hydatid disease (a disease related to infestation with tapeworm), failure to control the life cycle can result in a public health problem ...
Technical Centre for Agricultural and Rural Cooperation
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The role of the Wnt/β-catenin signaling pathway in the development of myopia [PDF]
, 2015 近视是一种常见的屈光不正。高度近视则可能伴随各种严重的并发症，甚至致盲。近视发生发展的机制迄今不清，目前也无法有效的防治。因此，近视发生发展的机制一直是眼科学研究的重要课题之一。本论文通过对近视发生过程中的基础研究，探讨近视发生的机制，以发现新的药物靶点及寻求治疗近视的新途径。 多巴胺D2受体（DopamineD2receptors,D2R）在调控眼球的屈光发育中发挥重要作用，但其具体的作用机制尚不清楚。我们考虑DA/D2R可能是通过调控下游的信号通路来发挥作用。在本论文中，我们用小鼠形觉剥夺近视 ...
刘真
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Repurposing salicylanilide anthelmintic drugs to combat drug resistant Staphylococcus aureus.
PLoS ONE, 2015 Staphylococcus aureus is a Gram-positive bacterium that has become the leading cause of hospital acquired infections in the US. Repurposing Food and Drug Administration (FDA) approved drugs for antimicrobial therapy involves lower risks and costs ...
Rajmohan Rajamuthiah +7 more
doaj +1 more source
PLoS ONEAimNiclosamide is an established anthelmintic substance and a promising candidate for treating cancer, viral infections, and other diseases. However, its solubility in aqueous media is low, and the systemic bioavailability of the commercially available ...
Niklas Walther +9 more
doaj +1 more source
A mini-review on the most important effective medicinal plants to treat hypertension in ethnobotanical evidence of Iran. [PDF]
, 2016 Nowadays, cardiovascular diseases are highly prevalent in human communities. Hypertension is a multifactorial disease which causes a mortality twice higher than general population.
Asadi-Samani, Majid. +1 more
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HeliyonPruritus is an uncomfortable sensation induced by various pruritogens, including serotonin. Serotonin, acting as an inflammatory mediator, can activate a histamine-independent pathway. Consequently, many anti-pruritus medications, such as antihistamines,
Zahra Ebrahim Soltani +4 more
doaj +1 more source
Binding interactions of niclosamide with serum proteins
Journal of Food and Drug Analysis, 2014 A study of the binding of niclosamide (NC) to serum proteins such as human serum albumin, hemoglobin, and globulin was carried out using fluorescence and UV-visible spectroscopy. Interactions between NC and these proteins were estimated by Stern-Volmer and van't Hoff equations.
openaire +3 more sources
An enzyme-linked immunosorbent assay for diagnostic detection of Taenia saginata copro-antigens in humans [PDF]
, 2017 An immunodiagnostic sandwich enzyme-linked immunosorbent assay (ELISA) was developed for the detection of soluble Taenia saginata antigens in stool samples (copro-antigens) of infected humans, using affinity-purified polyclonal antibodies obtained from ...
Deplazes, P. +4 more
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Lutter contre les parasites du mouton [PDF]
, 2015 Le niveau d’infestation parasitaire doit faire l’objet d’un contrôle. Dans le cas contraire, l’infestation peut entraîner des saignements, l’amaigrissement et même la mort de l’animal..
Technical Centre for Agricultural and Rural Cooperation
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