Results 131 to 140 of about 4,650 (177)

Niclosamide

2010
Niclosamide is an antihelminthic commercially available in Germany marketed under the trade name of Yomesan by Bayer. It was available until recently in the UK by the same brand name and until approximately 10 years ago in the United States under the brand name Niclocide.
Griffin, Paul M., McCarthy, James
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Injectable pegylated niclosamide (polyethylene glycol‐modified niclosamide) for cancer therapy

Journal of Biomedical Materials Research Part A, 2019
AbstractNiclosamide is an antihelminthic drug. Recent studies show that niclosamide exerts antitumor activity through inhibiting multiple signals including Wnt/β‐catenin, mTORC1, signal transducer and activator of transcription 3, NF‐κB, notch signals; however, the insolubility and poor bioavailability limits its potential clinic use, the aim of the ...
Rui, Ma, Zhen-Gang, Ma, Jin-Lai, Gao, Yu, Tai, Lan-Jun, Li, Hai-Bin, Zhu, Li, Li, De-Li, Dong, Zhi-Jie, Sun   +8 more
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Niclosamide Therapy for Tapeworm Infections

Annals of Internal Medicine, 1985
Excerpt Niclosamide [N-(2′-chloro-4′-nitrophenyl)-5-chlorosalicylamide] was developed at Bayer A. G.
R D, Pearson, E L, Hewlett
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A novel molluscicidal formulation of niclosamide

Parasitology Research, 2008
Snail control by molluscicides is an important strategy for schistosomiasis control in China. Currently, only one chemical molluscicide, niclosamide, which is used as 50% wettable powder of niclosamide ethanolamine salt (WPN), is commercially available for field snail control in China.
Jian-Rong, Dai, Wei, Wang, You-Sheng, Liang, Hong-Jun, Li, Xiao-Hong, Guan, Yin-Chang, Zhu   +5 more
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Anticancer Effects of Niclosamide in Human Glioblastoma

Clinical Cancer Research, 2013
Abstract Purpose: Glioblastoma is a highly malignant, invariably fatal brain tumor for which effective pharmacotherapy remains an unmet medical need. Experimental Design: Screening of a compound library of 160 synthetic and natural toxic substances identified the antihelmintic niclosamide as a previously unrecognized
Wieland, Anja, Trageser, Daniel, Gogolok, Sabine, Reinartz, Roman, Höfer, Heike, Keller, Mihaela, Leinhaas, Anke, Schelle, Ramona, Normann, Sabine, Klaas, Lil, Waha, Andreas, Koch, Philipp, Fimmers, Rolf, Pietsch, Torsten, Yachnis, Anthony T., Pincus, David W., Steindler, Dennis A., Brüstle, Oliver, Simon, Matthias, Glas, Martin, Scheffler, Björn   +20 more
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Pharmaceutical Cocrystals of Niclosamide

Crystal Growth & Design, 2012
Niclosamide (NCL) is an anthelmintic BCS class II drug of low solubility and high permeability. Pharmaceutical cocrystals of NCL were prepared with GRAS molecules, such as caffeine (CAF), urea (URE), p-aminobenzoic acid (PABA), theophylline (THPH), nicotinamide (NCT), and isonicotinamide (INA), to improve drug solubility. Neat grinding, wet granulation,
Palash Sanphui, S. Sudalai Kumar, Ashwini Nangia   +2 more
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Kinetic study and mechanism of Niclosamide degradation

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014
A spectrophotometric kinetic study of Niclosamide alkaline degradation as a function of drug concentration, alkaline concentration and temperature has been established utilizing double divisor-ratio spectra spectrophotometric method. The developed method allowed determination of Niclosamide in presence of its alkaline degradation products; namely; 2 ...
Hala E, Zaazaa, Maha M, Abdelrahman, Nouruddin W, Ali, Maimana A, Magdy, M, Abdelkawy   +4 more
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Genotoxic effects of niclosamide in Aspergillus nidulans

Mutation Research/Genetic Toxicology, 1989
A 2-5-month treatment with niclosamide, a widely used drug in developing countries, has been reported to induce lymphosarcomas in toad liver and kidney. The genotoxic effects of this drug have also been evaluated in Salmonella typhimurium, in somatic and germinal cells of mice and in human lymphocytes exposed in vitro and in vivo.
R A, de la Torre, R, de la Rúa Barceló, G, Hernández, J J, Espinosa, C, Cortinas de Nava   +4 more
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Niclosamide: Comprehensive Profile

2005
Publisher Summary This chapter presents a comprehensive profile of niclosamide, which is synthesized industrially by chlorinating salicylic acid in chlorobenzene to yield 5‐chlorosalicylic acid (I). Single‐crystal X‐ray structures of solvated forms of niclosamide revealed distinctly different modes of inclusion for different solvents.
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Metabolism of Niclosamide in Sediment and Water Systems

Journal of Agricultural and Food Chemistry, 2004
A series of experiments analyzed the kinetics and mechanisms of [(14)C]niclosamide degradation. The aerobic aquatic metabolism of [(14)C]niclosamide was studied in nonsterile river water/sediment mixtures. Test systems, maintained under aerobic conditions, were treated with niclosamide and incubated in the dark at 25.0 +/- 1.0 degrees C for 30 days ...
Phillip W, Graebing, J S, Chib, Terrance D, Hubert, William H, Gingerich   +3 more
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