Results 91 to 100 of about 256,874 (388)
Nicotinamide: A cardioprotective form of Vitamin B3 [PDF]
Arhiv za farmacijuNicotinamide, a form of vitamin B3, has emerged as a potential cardioprotective agent against ischemia-reperfusion (I/R) injury, a critical factor in the pathogenesis of myocardial infarction, heart failure, and other cardiovascular diseases.
Du Qingyou
doaj +1 more source
Recycling Nicotinamide. The Transition-State Structure of Human Nicotinamide Phosphoribosyltransferase [PDF]
Journal of the American Chemical Society, 2013 Human nicotinamide phosphoribosyltransferase (NAMPT) replenishes the NAD pool and controls the activities of sirtuins, mono- and poly-(ADP-ribose) polymerases, and NAD nucleosidase. The nature of the enzymatic transition-state (TS) is central to understanding the function of NAMPT.
Vern L. Schramm +2 more
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.This study develops a 3D vascular injury model using a microphysiological system that mimics key features of intimal hyperplasia. Antiproliferative drugs reduced VSMC proliferation but worsened endothelialdenudation. A combination of diphenyleneiodonium and quercetin effectively reduced proliferation and migration of VSMC and inflammation while ...
Ungsig Nam +7 more
wiley +1 more source
Surface Fluorescence Studies of Tissue Mitochondrial Redox State in Isolated Perfused Rat Lungs [PDF]
, 2012 We designed a fiber-optic-based optoelectronic fluorometer to measure emitted fluorescence from the auto-fluorescent electron carriers NADH and FAD of the mitochondrial electron transport chain (ETC).
Audi, Said H. +4 more
core +2 more sources
Studies on Nicotinamide Inhibitors
Experimental Biology and Medicine, 1952 Summary1. Of a series of 37 compounds tested, pyrazinamide, pyrazinoic acid and 2-sulfanilamide-5-nitropyridine were found to be nicotinamide antagonists for L. arabinosus. 2. Pyrazinamide was not an antagonist for rats or chicks.
J. J. Oleson +2 more
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.A poly(hydroxy‐oxazolidone) (PHOx) is synthesized from CO2‐based precursors, enabling the up‐cycling of this waste material. After synthesis, PHOx shows thermoplastic properties, and can therefore be processed by many temperature‐dependent techniques. PHOx is hemocompatible, anti‐adhesive, and biocompatible, which is demonstrated in vitro and in vivo ...
Sofia F. Melo +11 more
wiley +1 more source
PharmaceuticalsBackground/Objectives: Natural therapeutics for the treatment of diabetes mellitus represent a common challenge for many researchers. Thus, the aim of this study was to evaluate the antihyperglycemic and anti-inflammatory effects and the hepatic ...
Eman B. Abbas +5 more
doaj +1 more source
Kuwait Journal of Science, 2023 This study aims to prepare different types of Cu(II)-niacinamide complexes by layered solution method from various source of Cu(II) salts (sulphate, nitrate, chloride, and acetate) and in various M(II):niacinamide molar ratio (1:2, 1:4, and 1:6).
Nadia Cikita Handayani +4 more
doaj +1 more source
Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: potential role of Runx2 deacetylation. [PDF]
, 2012 Osteogenic repair in response to bone injury is characterized by activation and differentiation of mesenchymal stem cells (MSCs) to osteoblasts.
Aldinger, Constance +6 more
core +5 more sources
Advanced Materials, EarlyView.A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen +7 more
wiley +1 more source