Results 101 to 110 of about 159,186 (304)

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

Effect of Nicotinamide on Life Span Extension by CR

, 2013
(A) Nicotinamide shortens the life span of wild-type cells. Replicative life span analysis for BY4742 wild-type and sir2Δ cells on 2% glucose containing or lacking 5 mM nicotinamide (nic). Mean life span is shown in parentheses.(B) Nicotinamide partially
Eric A Westman (12441), Emily O Kerr (12439), Mitsuhiro Tsuchiya (12440), Di Hu (12438), Brian K Kennedy (12444), Matt Kaeberlein (12437), Nick Dang (12442), Stanley Fields (12443)   +7 more
core   +1 more source

scH16S‐Seq Maps Klebsiella pneumoniae‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

Advanced Science, EarlyView.
Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li, Yilong Yu, Fang Qin, Shenxing Li, Xuanheng Li, Peizhao Liu, Juanhan Liu, Haiqing Liu, Songqi Jing, Jianghao Zou, Sicheng Li, Jiayang Li, Tao Zheng, Yun Zhao, Jianan Ren, Xiuwen Wu   +15 more
wiley   +1 more source

Nicotinamide in dermatology

, 2010
Nicotinamide, also known as niacinamide or nicotinic acid amide, is the water-soluble, active form of vitamin B3. It has been increasingly studied for many different indications in the field of dermatology.
Kim, Nancy H, Kirsner, Robert S, Robert S Kirsner, Nancy H Kim   +3 more
core   +1 more source

Molecular Electrocatalysis Coupled With a Palladium Membrane Reactor Affords Selective Nitrogen Reduction

Advanced Science, EarlyView.
A palladium membrane reactor delivers active hydrogen to homogeneous nickel terpyridine catalysts, which then selectively hydrogenate dinitrogen to ammonia. ABSTRACT Ammonia production is a cornerstone of modern industry and society, yet the conventional Haber–Bosch process accounts for nearly 2% of the global CO2 emissions. A promising and potentially
Morgan McKee, Sai Phani Kumar Vangala, Farzaneh Farzinpour, Jasmin Wagner, Giacomo Pugliese, Hamed Heidarpour, Hossein Bemana, J. Felipe Estrada‐Ruiz, Jörg Daniels, Alessandro Bismuto, Ali Seifitokaldani, Nikolay Kornienko   +11 more
wiley   +1 more source

Investigation of male Carica papaya L. flower infusion concentration on the gastric histology of mice

Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ
This study aimed to investigate the effects of male Carica papaya L. flower infusion on the gastric histology of female mice induced with diabetes by streptozotocin. Diabetes was induced using streptozotocin (100 mg/kg BW) and nicotinamide (120 mg/kg BW).
Lâm Thị Khánh Phương, Trương Huy Bửu, Nguyễn Thị Thương Huyền   +2 more
doaj   +1 more source

The cocrystal nicotinamide-succinic acid (2/1)

, 2010
In the asymmetric unit of the crystal structure of nicotinamide-succinic acid (2/1), 2C(6)H(6)N(2)O center dot C4H6O4, there are two independent nicotinamide molecules in general positions and two half succinic acid molecules which lie about inversion ...
Laura J. Thompson, Adam Cowell, Voguri, Raja, Raja S. Voguri, Thompson, Laura, Tremayne, Maryjane, Louise Male, Male, Louise, Cowell, Adam, Maryjane Tremayne   +9 more
core   +1 more source

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

A Novel Peptide, Nicotinyl–Isoleucine–Valine–Histidine (NA–IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells

Marine Drugs, 2018
Nicotinamide (NA), a water-soluble vitamin B3, has been shown to exert cellular-protective effects against reactive oxygen species (ROS). In order to improve the cellular-protective effects of NA, we synthesized a novel compound, nicotinyl&ndash ...
Dong Hwee Son, Dong Joo Yang, Ji Su Sun, Seul Ki Kim, Namju Kang, Jung Yun Kang, Yun-Hee Choi, Jeong Hun Lee, Sang Hyun Moh, Dong Min Shin, Ki Woo Kim   +10 more
doaj   +1 more source

Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells

, 2018
Summary: Nicotinamide, the amide form of vitamin B3, is widely used in disease treatments and stem cell applications. However, nicotinamide's impact often cannot be attributed to its nutritional functions.
Ya Meng, James A. Thomson, Chengcheng Song, Guokai Chen, Zhili Ren, Xiaoxiao Zhou, Vivien Ya-Fan Wang, Faxiang Xu, Ligong Lu, Weiwei Liu   +9 more
core   +1 more source