Results 101 to 110 of about 155,595 (297)
Advanced Science, EarlyView.SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long +12 more
wiley +1 more source
, 2016 Ahmed S Zidan,1,2 Osama AA Ahmed,1,3 Bader M Aljaeid1 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia; 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of
Aljaeid BM, Zidan AS, Ahmed OA
core
Amyotrophic lateral sclerosis and intestinal microbiota—toward establishing cause and effect
Gut Microbes, 2020 The intestinal microbiota may be involved, through metabolic gut–brain interactions, in a variety of neurological conditions. In this addendum, we summarize the findings of our recent study investigating the potentially modulatory influence of the ...
Marc Gotkine +2 more
doaj +1 more source
Quantitative fluorimetric analysis of plant nicotinamide
, 2001 Fluorimetry was used to measure the amount of nicotinamide in plant samples. The nicotinamide was extracted and purified from plant tissues with ethyl acetate; converted to the fluorescent derivative, N1-methylnicotinamide, by reacting with methyl iodide;
Wenzheng Feng +3 more
core +2 more sources
NAMPT (nicotinamide phosphoribosyltransferase) [PDF]
, 2012 Review on NAMPT (nicotinamide phosphoribosyltransferase), with data on DNA, on the protein encoded, and where the gene is ...
Dalamaga, M, Koumaki, V
core +1 more source
Advanced Science, EarlyView.Magneto‐NIR‐II‐programmed NFSH nanozymes integrate magnetic blood–brain barrier (BBB) translocation, CD44 targeting, multimodal imaging, and cascade catalytic therapy for glioblastoma. Alternating magnetic fields and NIR‐II irradiation amplify ferroptosis, release H2S, suppress autophagic and mitophagic repair, and reshape the immune microenvironment ...
Ruocan Liu +7 more
wiley +1 more source
Advanced Science, EarlyView.CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin +17 more
wiley +1 more source
NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells [PDF]
, 2016 NAD+ is a vital redox cofactor and a substrate required for activity of various enzyme families, including sirtuins and poly(ADP-ribose) polymerases. Supplementation with NAD+ precursors, such as nicotinamide mononucleotide (NMN) or nicotinamide riboside
Boutant, Marie +15 more
core +3 more sources
Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy
Advanced Science, EarlyView.This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao +5 more
wiley +1 more source
Nicotinamide Methylation in patients with Cirrhosis.
, 1994 Methylation reactions play an important role in the transformation of endogenous and exogenous substances. Up to 85% of all transmethylation reactions occur in the liver. Several studies have shown that these metabolic processes are greatly influenced by
CUOMO, ROSARIO +5 more
core +1 more source