Results 171 to 180 of about 256,874 (388)
ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors
Advanced Science, EarlyView.This study unveils that ACSS2‐driven acetate metabolism fuels histone pan‐acetylation in pancreatic neuroendocrine tumors (PNETs), remodeling the epigenetic landscape. The ACSS2/AATF axis transcriptionally activates soluble FasL (sFasL), which engages Fas receptors on infiltrating CD8+ T cells to trigger caspase‐8/3‐mediated apoptosis.
Qin Dang +14 more
wiley +1 more source
Magnetically Controllable and Degradable Milliscale Swimmers as Intraocular Drug Implants
Advanced Science, EarlyView.Magnetically controllable degradable milliscale swimmers (MDMS) offer a promising alternative to commercial intraocular drug implants, reducing complications like implant dislocation and uncontrolled drug release. MDMS achieve high velocities in ocular environments, enable real‐time imaging, and deliver drugs effectively without disrupting retinal ...
Erdost Yildiz +8 more
wiley +1 more source
Terapi Topikal Tretinoin 0,025% + Zinc Oral Dibandingkan Topikal Nicotinamide 4% + Zinc Oral Pada Akne Vulgaris [PDF]
, 2017 Latar Belakang : Akne vulgaris merupakan penyakit kulit yang umum terjadi pada remaja dan dewasa. Terapi topikal untuk akne dapat digunakan sebagai monoterapi maupun kombinasi dengan terapi sistemik.
Usodo, G. P. (Gloria) +1 more
core
Advanced Science, EarlyView.Through modifying the switchable µ‐oxo bridged FeIII‐porphyrins moiety and NADH mimics into a metal‐organic capsule, multiple responsive manners for O2 activation, chemical oxygenation and metabolic transformation have been demonstrated for upregulating intracellular methionine depletion and accumulation of methionine sulfoxide to achieve effective ...
Chunming Ma +5 more
wiley +1 more source
Substituted Nicotinamide Analogues of Nicotinamide Adenine Dinucleotide
Journal of Biological Chemistry, 1963 Nathan O. Kaplan, Paul Walter
openaire +3 more sources
Advanced Science, EarlyView.This study engineers Yarrowia lipolytica to produce succinic acid (SA) from lignocellulosic biomass. Adaptive evolution and multi‐omics analysis identify regulators that alleviate xylose metabolic disorder. Multi‐copy integration of xylose metabolic genes resolves redox imbalances from a futile fatty acid cycle, producing high‐titer SA from corn stover
Yutao Zhong +7 more
wiley +1 more source
Reversibility of Age-related Oxidized Free NADH Redox States in Alzheimer's Disease Neurons by Imposed External Cys/CySS Redox Shifts. [PDF]
, 2019 Redox systems including extracellular cysteine/cystine (Cys/CySS), intracellular glutathione/oxidized glutathione (GSH/GSSG) and nicotinamide adenine dinucleotide reduced/oxidized forms (NADH/NAD+) are critical for maintaining redox homeostasis. Aging as
Brewer, Gregory J +3 more
core
METHYLATION OF NICOTINAMIDE WITH A SOLUBLE ENZYME SYSTEM FROM RAT LIVER
, 1951 Giulio L. Cantoni
openalex +1 more source
Real‐Time Detection of Reduced Nitroreductase with a Reversible Fluorescent Probe
Advanced Science, EarlyView.The first reversible binding probe (rNTRp) is presented that selectively detects the nitroreductase enzyme's active, reduced form (red‐NTR) with a fluorescence turn‐on response. Contrary to the conventional reaction‐based probes known to date, which provide only static information on the accumulated enzyme activity at a given time, rNTRp allows ...
Sourav Sarkar +8 more
wiley +1 more source