Results 211 to 220 of about 155,595 (297)

Interpretation of Key Updates in the 36th Edition of Clinical and Laboratory Standards Institute M100 Standard

iLABMED, EarlyView.
ABSTRACT The Clinical and Laboratory Standards Institute M100 document serves as a cornerstone standard for clinical microbiology laboratories in China. Maintaining the scientific rigor of its predecessors, the 36th edition incorporates updated epidemiological cutoff values, pharmacokinetic/pharmacodynamic data, and clinical efficacy evidence to revise
Kanghong Xu, Qi Wang, Hui Wang
wiley   +1 more source

Irreversible NADH Cleavage by a Mitochondria-Targeted Metal-Free Photoredox Sensitizer with Activity in Cancer Cells. [PDF]

ACS Med Chem Lett
Neto JC, Falomir E, Miravet JF, Galindo F.   +3 more
europepmc   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Human meibomian gland organoids to study epithelial homeostasis and dysfunction. [PDF]

Protein Cell
Yu C, Wan X, Wei J, Xu Z, Wu X, Wang X, Mi Y, Zhang Y, Wu D, Zhou X, Le Q, Xu J, Zhao C, Sun X, Zhou X, Hong J, Zhao B.   +16 more
europepmc   +1 more source

Soil‐derived, gut‐dominant generalist bacteria shape the fitness of folivorous larvae

iMeta, EarlyView.
Whether Lepidoptera harbor a conserved core gut microbiome has long remained contentious. Through large‐scale microbiome profiling of folivorous larvae, their host plants, and associated soils across three climatically distinct regions of China, we identify two soil‐derived generalist bacteria, Ralstonia insidiosa and Delftia sp., that colonize 97.92 ...
Yu‐xuan Zheng, Ying Wang, Xiao‐man Zhang, Qian Jin, Yan Zhang, Gui‐fang Wang, Yong‐qi Shao, Jing Li, Cheng Sun, Wei‐dong Kong, Cai‐qing Yang, Ai‐bing Zhang   +11 more
wiley   +1 more source

A phase-II randomized controlled pilot study of nicotinamide riboside supplementation in older adults with amnestic mild cognitive impairment. [PDF]

Alzheimers Dement
Martens CR, Decker KP, DeConne TM, Sanjana F, Horvat F, Rizzi NA, Awad C, Habash E, Hobson JC, Kramer MK, Armstrong ML, Reisdorph N, Pohlig RT, Lanzi AM, Johnson CL, Cohen ML, Ellison JM.   +16 more
europepmc   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Precision Nanodelivery Enables Spatiotemporal Control of NAD⁺ Metabolism in Ageing and Disease. [PDF]

Int J Nanomedicine
Pei Z, Wang X, Liang F, Zhong M, Jiang Q, Li H.   +5 more
europepmc   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source