Therapeutic effects of nicotinamide mononucleotide and Indian gooseberry in oxidative stress and inflammation-induced damage on human retinal pigment epithelial cells: A pilot study. [PDF]
Lee D, Nahar JS, Kim S, Lim SS.
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NAD<sup>+</sup>‒circadian rhythm coupling in dementia. [PDF]
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Deficiency of the NAD(P)HX metabolic repair system: a treatable mitochondrial disease. [PDF]
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An ART-fold Rhs toxin from Pluralibacter gergoviae defines Tne5, a novel family of NAD(P) glycohydrolases effectors. [PDF]
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Mitochondrial Resilience in Glaucoma: Targeting NAD<sup>+</sup> Metabolism and Oxidative Stress in Retinal Ganglion Cell Degeneration with Nicotinamide Riboside and Berberine: Preliminary Clinical Evidence. [PDF]
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Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase
Bioorganic and Medicinal Chemistry Letters, 2018Nicotinamide N-methyltransferase (NNMT) has been linked to obesity and diabetes. We have identified a novel nicotinamide (NA) analog, compound 12 that inhibited NNMT enzymatic activity and reduced the formation of 1-methyl-nicotinamide (MNA), the primary metabolite of NA by ∼80% at 2 h when dosed in mice orally at 50 mg/kg.
Takeshi Yura, Sven Ruf, Thomas Langer
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AbstractNicotinamide, an amide form of vitamin B3, boosts cellular energy and regulates poly‐ADP‐ribose‐polymerase 1, an enzyme with important roles in DNA repair and the expression of inflammatory cytokines. Nicotinamide shows promise for the treatment of a wide range of dermatological conditions, including autoimmune blistering disorders, acne ...
Andrew C Chen, Diona L Damian
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