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NAD<sup>+</sup>‒circadian rhythm coupling in dementia. [PDF]

open access: yesAlzheimers Dement
Zhang SQ   +7 more
europepmc   +1 more source

Deficiency of the NAD(P)HX metabolic repair system: a treatable mitochondrial disease. [PDF]

open access: yesOrphanet J Rare Dis
Xu C   +16 more
europepmc   +1 more source
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Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase

Bioorganic and Medicinal Chemistry Letters, 2018
Nicotinamide N-methyltransferase (NNMT) has been linked to obesity and diabetes. We have identified a novel nicotinamide (NA) analog, compound 12 that inhibited NNMT enzymatic activity and reduced the formation of 1-methyl-nicotinamide (MNA), the primary metabolite of NA by ∼80% at 2 h when dosed in mice orally at 50 mg/kg.
Takeshi Yura, Sven Ruf, Thomas Langer
exaly   +3 more sources

Nicotinamide and the skin

Australasian Journal of Dermatology, 2014
AbstractNicotinamide, an amide form of vitamin B3, boosts cellular energy and regulates poly‐ADP‐ribose‐polymerase 1, an enzyme with important roles in DNA repair and the expression of inflammatory cytokines. Nicotinamide shows promise for the treatment of a wide range of dermatological conditions, including autoimmune blistering disorders, acne ...
Andrew C Chen, Diona L Damian
openaire   +2 more sources

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