Results 221 to 230 of about 222,121 (295)

Application of NMRK immobilized enzymes in the synthesis of NMN. [PDF]

PLoS One
Yang S, Xiang T, Qian J, Sun W, Liu W, Yi N, Qin ZH.   +6 more
europepmc   +1 more source

The Mycobacterium tuberculosis Rv0132c Gene Product Mtb‐FGD2 Can Act as an F420‐Dependent Glucose Dehydrogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi, Matthew Snee, Richard B. Tunnicliffe, Linus O. Johanissen, Matthew J. Cliff, Colin W. Levy, Derren J. Heyes, Marina Golovanova, Thomas A. Jowitt, Sam Hay, Andrew W. Munro, Jonathan P. Waltho, David Leys   +12 more
wiley   +1 more source

First-in-Human Phase I Study of KPT-9274, a First-in-Class Dual Inhibitor of PAK4 and NAMPT, in Patients with Advanced Solid Malignancies. [PDF]

Target Oncol
Razak A, Mahipal A, Diamond JR, Ribas A, Berlin JD, Azmi AS, Mark T, Walker CJ, Chai Y, Kashyap T, Gudi G, Naing A.   +11 more
europepmc   +1 more source

A Combined Colon Organoid‐Sensory Neuron Model Reveals Epithelial Contribution to Moringin Efficacy Against Painful Inflammatory Bowel Disease

Phytotherapy Research, EarlyView.
Experimental workflow and main findings of the study. ABSTRACT Visceral pain is a major symptom of inflammatory bowel diseases (IBDs), requiring effective treatment strategies. Gut epithelium, beyond maintaining barrier integrity and microbiota homeostasis, modulates neurosensorial circuitries, influencing visceral sensitivity.
Francesco Margiotta, Elena Lucarini, Alessandra Toti, Maria Giovanna Cataldi, Clara Ciampi, Gina Rosalinda De Nicola, Lorenzo Di Cesare Mannelli, Carla Ghelardini   +7 more
wiley   +1 more source

Structural flexibility of the nicotinamide group of NADH in butanol dehydrogenase YqdH from Fusobacterium nucleatum. [PDF]

PLoS One
Bai X, Nam KH, Xu Y.
europepmc   +1 more source

Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation–Energy Axis?

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo, Cristiana Lucia Rita Lipari, Aurora Patti, Maria Angela Sortino   +3 more
wiley   +1 more source

Circulating eNAMPT in Glaucoma: A Semi-Quantitative Plasma Analysis Before and After Nicotinamide Supplementation. [PDF]

Transl Vis Sci Technol
Vallbona-Garcia A, Gustavsson ST, Gorgels TGMF, Tribble JR, Webers CAB, Smeets HJM, Jóhannesson G, Williams PA, Benedikter BJ.   +8 more
europepmc   +1 more source

The scale matters: A review on stimuli‐responsive microrobots categorized by scale for biomedical applications

Responsive Materials, EarlyView.
We systematically summarize how each scale dictates fundamental choices in design feature, manufacturing technology, driving mechanism, and control strategy, which are inherently governed by scale‐dominated physical principles. Furthermore, the application of scale‐determined operation modes of microrobots across different stages of medical ...
Hang Yin, Yujing Li, Guanghao Wu, Yubing Guo   +3 more
wiley   +1 more source

Birth season shapes the infant metabolome and development in Tanzania: a secondary explorative analysis of the early life interventions for childhood growth and development in Tanzania (ELICIT) trial. [PDF]

Nat Commun
Wimborne EA, Hampel D, Allen L, van der Veen DR, Panic G, Panchal M, Platts-Mills JA, Mduma E, Blacy L, Jatsoh S, Mdoe P, Scharf R, DeBoer MD, Swann JR.   +13 more
europepmc   +1 more source

Spectroscopic Signatures of Doping in Thin Films of Semiconducting Single‐Walled Carbon Nanotubes

Small, EarlyView.
This review presents an overview of the spectroscopic changes of semiconducting single‐walled carbon nanotubes upon chemical, electrochemical or electrostatic doping. The presence of holes or electrons directly affects visible to far‐infrared absorption, near‐infrared fluorescence and electroluminescence as well as Raman spectra, which enables in‐situ ...
Jana Zaumseil
wiley   +1 more source