Results 261 to 270 of about 256,874 (388)

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

Clinical Pharmacology &Therapeutics, EarlyView.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano, Aleksandra Galetin, Yoshiko Tomita, Kathleen M. Giacomini, Xiaoyan Chu, Xinning Yang, Toshimichi Nakamura, Hiroyuki Kusuhara, Yuichi Sugiyama   +8 more
wiley   +1 more source

NAD + metabolism and function in innate and adaptive immune cells. [PDF]

J Inflamm (Lond)
Mann R, Stavrou V, Dimeloe S.
europepmc   +1 more source

Metal‐Free Organocatalytic Formylation by CO2‐Masked Carbene Functionalized Graphene Oxide Nanosheets

ChemSusChem, EarlyView.
Here, the authors show the use of an organocatalytic process for the metal‐free N‐/S‐formylation of various NH and SH functionalities using a CO2‐protected NHC‐functionalized graphene oxide nanosheets. The authors discovered the direct N‐formylation of the in situ‐generated Tröger's base linker through reductive catalytic conversion of CO2.
Swarbhanu Ghosh, Parisa A. Ariya
wiley   +1 more source

Modification of Metabolic Pattern by Variation of Nicotinamide Adenine Dinucleotide Phosphate Level

, 1969
Yukio Yamamoto
openalex   +2 more sources

Extraction and Quantitation of Nicotinamide Adenine Dinucleotide Redox Cofactors.

Antioxidants and Redox Signaling, 2018
Wenyun Lu, Lin Wang, Li Chen, Sheng Hui, J. Rabinowitz   +4 more
semanticscholar   +1 more source

Biomimetic chloroplasts: Two‐phase microfluidic platforms with selective permeability for artificial photosynthesis

Droplet, EarlyView.
We present a biomimetic chloroplast system that integrates light‐dependent and light‐independent reactions, reaction compartments, and selectively permeable interfaces using a biphasic microfluidic droplet platform. This system enables continuous substrate–product exchange, mitigating product inhibition and side reactions, thus enhancing reaction ...
Guanxiong Wang, Meiying Hong, Chonghui Yang, Menghan Yang, Gaozhen Zhao, Haixia Liu, Rui Shen, Siping Wang, Xuming Zhang, Xiaowen Huang, Yaolei Wang   +10 more
wiley   +1 more source

Nicotinic acid riboside maintains NAD⁺ homeostasis and ameliorates aging-associated NAD⁺ decline. [PDF]

Cell Metab
Song WS, Shen X, Du K, Ramirez CB, Park SH, Cao Y, Le J, Bae H, Kim J, Chun Y, Khong NJ, Kim M, Jung S, Choi W, Lopez ML, Said Z, Song Z, Lee SG, Nicholas D, Sasaki Y, Milbrandt J, Imagawa DK, Skowronska-Krawczyk D, Chen D, Lee G, Jang C, Yang Q.   +26 more
europepmc   +1 more source

NMNAT3 is protective against the effects of neonatal cerebral hypoxia-ischemia [PDF]

, 2017
Araki, Toshiyuki, Galindo, Rafael, Greenberg, Marianne Banks, Holtzman, David M, Mehta, Nehali, Milbrandt, Jeffrey, Sasaki, Yo   +6 more
core   +2 more sources

Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo‐Pyridyl Synthetic Cannabinoid Receptor Agonist CH‐FUBBMPDORA

Drug Testing and Analysis, EarlyView.
Another Chinese generic ban‐evading SCRA, CH‐FUBBMPDORA, has emerged. This study reports its first identification in Europe, its analytical characterization (NMR, Raman, FTIR, GC–MS, and HRMS), its cannabinoid activation potential in a βarr2 recruitment assay, and its metabolization profile.
Marie H. Deventer, Maria Carmela Emanuele, Brianna N. Stang, Katleen Van Uytfanghe, Jessica Masson, Xavier Bouvot, Catherine Lamoureux, Alessandro Proposito, Fabiano Reniero, Margaret V. Holland, Alex J. Krotulski, Luisa Mannina, Christophe P. Stove, Claude Guillou   +13 more
wiley   +1 more source

Metabolic Identification Based on Proposed Mass Fragmentation Pathways of the Anabolic Steroid Bolasterone by Gas Chromatography Tandem Mass Spectrometry

Drug Testing and Analysis, EarlyView.
The metabolism of bolasterone in liver microsomes and in urine samples of rats orally treated was evaluated due to no availability of its extensive metabolism studies. Its mono‐ and di‐hydroxylated metabolites were detected by GC‐EI‐MS/MS, and the fragmentation pathways of metabolites were suggested.
Anca Raluca Muresan, Khandoker Asiqur Rahaman, Farzana Binte Rafique, Junghyun Son, Min‐Jung Kang, Oh‐Seung Kwon   +5 more
wiley   +1 more source