Results 251 to 260 of about 155,595 (297)

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

Nicotinamide Improves Skin Photoaging in Mice by Delaying Cellular Senescence and Suppressing the Senescence-Associated Secretory Phenotype. [PDF]

Curr Issues Mol Biol
Tang XY, Lu KJ, Zhu R, Gao Y, Wei DY, Zhang XY, Ma YC, Wang FF, Zou CG.   +8 more
europepmc   +1 more source

Sarcopenia and satellite cell homeostasis disruption: the dual function of NAD+ metabolism. [PDF]

Front Nutr
Li C, Ai Y, Yan J, Wu S.
europepmc   +1 more source

Biosynthesis and enzymology of azaindane natural products. [PDF]

J Antibiot (Tokyo)
Quan Z, Awakawa T.
europepmc   +1 more source

Inhibitory Effects on the Polyol Pathway in Type 2 Diabetic Rats by Chickpea Flavonoid Extract. [PDF]

Foods
Wang J, Yang T, Guo J, Li Y, Fu Y.
europepmc   +1 more source

Safety and efficacy of individualised exercise and NAD⁺ precursor supplementation in patients with Friedreich's ataxia in the USA: a single-centre, 2 × 2 factorial, randomised controlled trial. [PDF]

Lancet Neurol
Lin KY, Bucha A, McSweeney K, Wade KL, Karaj A, Tamaroff J, O'Malley S, Chung NM, Cilenti NA, Wanner J, Adzika GK, Mesaros C, Blair IA, Rojsajjakul T, Serai S, Farmer J, Bryant K, Lu Y, Harhay MO, Weber DR, Paridon SM, Seifert EL, Putt ME, Zamani P, Baur JA, Lynch DR, McCormack SE.   +26 more
europepmc   +1 more source

Replacement soaking for human tankyrase 2 enables studies on substrate analogues and inhibitors. [PDF]

Acta Crystallogr D Struct Biol
Pääkkönen J, Sowa ST, Bosetti C, Lehtiö L.   +3 more
europepmc   +1 more source

Simultaneous quantitation of nicotinamide riboside, nicotinamide mononucleotide and nicotinamide adenine dinucleotide in milk by a novel enzyme-coupled assay

Food Chemistry, 2017
Nicotinamide riboside, the most recently discovered form of vitamin B3, and its phosphorylated form nicotinamide mononucleotide, have been shown to be potent supplements boosting intracellular nicotinamide adenine dinucleotide (NAD) levels, thus ...
Simone Ummarino, Giuseppe Orsomando, Francesca Mazzola   +2 more
exaly   +2 more sources

Pharmacokinetics of the SABRE agent 4,6-d2-nicotinamide and also nicotinamide in rats following oral and intravenous administration [PDF]

European Journal of Pharmaceutical Sciences, 2019
To prepare the way for using the isotopically labelled SABRE hyperpolarised 4,6-d2-nicotinamide as an MRI agent in humans we have performed an in-vivo study to measure its pharmacokinetics in the plasma of healthy rats after intravenous and oral ...
Peter Rayner, Simon Duckett
exaly   +2 more sources