Results 261 to 270 of about 155,595 (297)

Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase

Bioorganic and Medicinal Chemistry Letters, 2018
Nicotinamide N-methyltransferase (NNMT) has been linked to obesity and diabetes. We have identified a novel nicotinamide (NA) analog, compound 12 that inhibited NNMT enzymatic activity and reduced the formation of 1-methyl-nicotinamide (MNA), the primary metabolite of NA by ∼80% at 2 h when dosed in mice orally at 50 mg/kg.
Takeshi Yura, Sven Ruf, Thomas Langer
exaly   +3 more sources

Nicotinamide and the skin

Australasian Journal of Dermatology, 2014
AbstractNicotinamide, an amide form of vitamin B3, boosts cellular energy and regulates poly‐ADP‐ribose‐polymerase 1, an enzyme with important roles in DNA repair and the expression of inflammatory cytokines. Nicotinamide shows promise for the treatment of a wide range of dermatological conditions, including autoimmune blistering disorders, acne ...
Andrew C Chen, Diona L Damian
openaire   +2 more sources

Nicotinamide suppresses hyperphosphatemia in hemodialysis patients [PDF]

Kidney International, 2004
Nicotinamide suppresses hyperphosphatemia in hemodialysis patients.BackgroundThe use of calcium- or aluminum-based phosphate binders against hyperphosphatemia is limited by the adverse effects of hypercalcemia or aluminum toxicity in long-term ...
Tsutomu Fukuwatari
exaly   +2 more sources

Effect of Nicotinamide Administration on the Tryptophan-Nicotinamide Pathway in Humans

International Journal for Vitamin and Nutrition Research, 2007
The vitamin nicotinamide is synthesized in the liver from tryptophan, and distributed to non-hepatic tissues. Although it is generally accepted that 60 mg tryptophan is equivalent to 1 mg nicotinamide in humans, the conversion ratio of tryptophan to nicotinamide is changeable.
Tsutomu, Fukuwatari, Katsumi, Shibata
openaire   +2 more sources

Lipid Peroxidation in Nicotinamide-Deficient and Nicotinamide-Supplemented Rats

International Journal for Vitamin and Nutrition Research, 2000
Supplementation or deficiency of nicotinamide in rats may interfere with the oxidative balance, with excess leading to greater lipid peroxidation, measured by TBARS, and deficiency causing a greater consumption of antioxidants such as vitamin E and glutathione.
S S, Melo, M S, Meirelles, A A, Jordão Júnior, H, Vannucchi   +3 more
openaire   +2 more sources

Effects of Nicotinamide on Xenotransplantation

Transplantation Proceedings, 1998
ISLET transplantation from rodents is a useful model for developing potential approaches to both xenografts and allografts in humans. One of the major obstacles to pancreatic islet transplantation is the limited yield of islets from the donor pancreas.
M B, Marqués, M M, Esteban, A, Villar, C, García-Pravia, L, Barneo   +4 more
openaire   +2 more sources

Nicotinamide and neurocognitive function

Nutritional Neuroscience, 2014
Nicotinamide, or vitamin B3, is a precursor of nicotinamide adenine dinucleotide (NAD(+)) and is involved in a multitude of intra- and inter-cellular processes, which regulate some of the cell's metabolic, stress, and immune responses to physiological or pathological signals.
George, Rennie, Andrew C, Chen, Haryana, Dhillon, Janette, Vardy, Diona L, Damian   +4 more
openaire   +2 more sources

Photoprotective effects of nicotinamide

Photochemical & Photobiological Sciences, 2010
Sun protective measures can reduce numbers of both precancerous actinic keratoses and cutaneous squamous cell carcinomas within relatively short periods of time even in high-risk populations. Sunscreens, which tend to provide greater protection against shortwave UVB than against longer wavelength UVA radiation, can however provide only partial ...
openaire   +2 more sources

Nicotinamide and Diabetes Prevention

Nutrition Reviews, 2009
Individuals at high risk of developing insulin-dependent diabetes mellitus can now be identified by immunologic testing. This ability to predict future cases of IDDM raises the possibility of intervention to prevent the disease. An intervention study in New Zealand using nicotinamide treatment showed a 50% reduction in the development of IDDM in a 5 ...
openaire   +2 more sources

Synthesis of Glycosides of Nicotinamide and Nicotinamide Mononucleotide

Synthesis, 1981
I. A. Mikhailopulo, T. I. Pricota, V. A. Timoshchuk, A. A. Akhrem   +3 more
openaire   +1 more source