Results 31 to 40 of about 256,874 (388)

Reduced nicotinamide mononucleotide is a new and potent NAD+ precursor in mammalian cells and mice

The FASEB Journal, 2021
Nicotinamide adenine dinucleotide (NAD+) homeostasis is constantly compromised due to degradation by NAD+‐dependent enzymes. NAD+ replenishment by supplementation with the NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR ...
R. Zapata-Pérez, A. Tammaro, Bauke V. Schomakers, Angelique M. L. Scantlebery, S. Denis, H. Elfrink, Judith Giroud-Gerbetant, C. Cantó, C. Lopez-Leonardo, Rebecca L. McIntyre, M. van Weeghel, Á. Sánchez-Ferrer, R. Houtkooper   +12 more
semanticscholar   +1 more source

Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: A crossover randomized clinical trial

Clinical and Experimental Ophthalmology, 2020
Retinal ganglion cells endure significant metabolic stress in glaucoma but maintain capacity to recover function. Nicotinamide, a precursor of NAD+, is low in serum of glaucoma patients and its supplementation provides robust protection of retinal ...
Flora Hui, Jessica Tang, Pete A. Williams, M. McGuinness, X. Hadoux, R. Casson, M. Coote, I. Trounce, K. Martin, P. van Wijngaarden, J. Crowston   +10 more
semanticscholar   +1 more source

Pre-emptive Short-term Nicotinamide Mononucleotide Treatment in a Mouse Model of Diabetic Nephropathy

Journal of the American Society of Nephrology, 2021
Visual Abstract Significance Statement Nicotinamide mononucleotide (NMN) is the precursor of NAD+ that activates Sirtuin1 (Sirt1), an antiaging enzyme.
I. Yasuda, K. Hasegawa, Yusuke Sakamaki, Hirokazu Muraoka, T. Kawaguchi, Ei Kusahana, Takashi Ono, T. Kanda, H. Tokuyama, S. Wakino, H. Itoh   +10 more
semanticscholar   +1 more source

Nicotinamide Riboside—The Current State of Research and Therapeutic Uses

Nutrients, 2020
Nicotinamide riboside (NR) has recently become one of the most studied nicotinamide adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits mediated via elevated NAD+ content in the body.
Mario Mehmel, N. Jovanović, U. Spitz
semanticscholar   +1 more source

Metabolic engineering of Escherichia coli for biosynthesis of β‐nicotinamide mononucleotide from nicotinamide

Microbial Biotechnology, 2021
The β‐nicotinamide mononucleotide (NMN) is a key intermediate of an essential coenzyme for cellular redox reactions, NAD. Administration of NMN is reported to improve various symptoms, such as diabetes and age‐related physiological decline.
Yang Liu, Bo Yu
semanticscholar   +1 more source

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

Nature Communications, 2018
Nicotinamide adenine dinucleotide (NAD+) has emerged as a critical co-substrate for enzymes involved in the beneficial effects of regular calorie restriction on healthspan.
C. Martens, Blair A. Denman, Melissa R Mazzo, M. Armstrong, N. Reisdorph, M. McQueen, M. Chonchol, D. Seals   +7 more
semanticscholar   +1 more source

Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding [PDF]

, 2016
Funding: The Scottish Government's Rural and Environment Science and Analytical Services Division.Peer ...
Drew, Janice E., Farquharson, Andrew J., Horgan, Graham W, Williams, Lynda M.   +3 more
core   +1 more source

An Improved Method for the Quaternization of Nicotinamide and Antifungal Activities of Its Derivatives

Molecules, 2019
The quaternization reactions of nicotinamide, with different electrophiles: methyl iodide and substituted 2-bromoacetophenones (4-Cl, 4-Br, 4-H, 4-CH3, 4-F, 4-OCH3, 4-Ph, 2-OCH3, 4-NO2) are reported.
Tamara Siber, Valentina Bušić, Dora Zobundžija, Sunčica Roca, Dražen Vikić-Topić, Karolina Vrandečić, Dajana Gašo-Sokač   +6 more
doaj   +1 more source

Gene regulation and epigenotype in Friedreich's ataxia [PDF]

, 2008
Friedreich??????s ataxia (FRDA) is known to be provoked by an abnormal GAA-repeat expansion located in the first intron of the FXN gene. As a result of the GAA expansion, patients exhibit low levels of FXN mRNA, leading to FRDA.
Rothe, Nadine, Rothe, Nadine
core   +2 more sources

Creating enzymes and self-sufficient cells for biosynthesis of the non-natural cofactor nicotinamide cytosine dinucleotide

Nature Communications, 2021
Nicotinamide adenine dinucleotide (NAD) and its reduced form are indispensable cofactors in life. Diverse NAD mimics have been developed for applications in chemical and biological sciences.
Xueying Wang, Yanbin Feng, Xiaojia Guo, Qian Wang, Siyang Ning, Qing Li, Junting Wang, Lei Wang, Z. Zhao   +8 more
semanticscholar   +1 more source