Results 91 to 100 of about 134,103 (347)
Nutrition-Based Modulation of Poly-ADP-Ribosylation and its possible role in Alzheimer’s disease [PDF]
, 2015 Alzheimer’s Disease (AD) is the most common neurodegenerative disease and the main reason of dementia in the elderly. On the pathological point of view, it is characterized by extracellular aggregates of amyloid peptides and intracellular deposits of tau
Fuso, Andrea, Martire, Sara
core
Advanced Science, EarlyView.Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song +9 more
wiley +1 more source
Black tea water kefir beverage : a thesis submitted in partial fulfilment of the requirement for the degree of Master of Food Technology, Massey University, Albany, New Zealand [PDF]
, 2017 Fermented foods and beverages play an important role in the human diet as they provide essential nutrients as well as contribute towards prevention of diseases.
Subardjo, Maria Vina Kania
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The human NAD metabolome: Functions, metabolism and compartmentalization [PDF]
, 2015 The metabolism of NAD has emerged as a key regulator of cellular and organismal homeostasis. Being a major component of both bioenergetic and signaling pathways, the molecule is ideally suited to regulate metabolism and major cellular events.
Kulikova, Veronika +2 more
core +2 more sources
Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice
Advanced Science, EarlyView.Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia +29 more
wiley +1 more source
Gentle Label‐Free Nonlinear Optical Imaging Relaxes Linear‐Absorption‐Mediated Triplet
Advanced Science, EarlyView.The phototoxicity in nonlinear optical microscopy arises mainly from linear absorption of intrinsic biomolecules rather than nonlinear absorption. This mechanism is supported by a reproducible phototoxicity assay based on widely available chicken breast.
Geng Wang +4 more
wiley +1 more source
Review on Biosynthesis of β-Nicotinamide Mononucleotide and Its Derivatives [PDF]
Shipin Kexueβ-Nicotinamide mononucleotide (NMN) is present in all organisms and has attracted widespread attention as a nutritional supplement and pharmaceutical product for the treatment of various diseases, such as Alzheimer’s disease, cancer, aging, and vascular ...
WANG Zhaoying, GUO Xinhao, HUANG Xinhe, CHEN Zhuoyan, LIU Yueqi, LI Juan, CHEN Ning, FAN Xiaoguang
doaj +1 more source
Characterisation of FAD-family folds using a machine learning approach [PDF]
, 2002 Flavin adenine dinucleotide (FAD) and its derivatives play a crucial role in biological processes. They are major organic cofactors and electron carriers in both enzymatic activities and biochemical pathways. We have analysed the relationships between
Gilbert, D, Tan, A C, Tuson, A
core
Evaluation of rate law approximations in bottom-up kinetic models of metabolism. [PDF]
, 2016 BackgroundThe mechanistic description of enzyme kinetics in a dynamic model of metabolism requires specifying the numerical values of a large number of kinetic parameters.
A Bordbar +49 more
core +4 more sources
Advanced Science, EarlyView.Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang +9 more
wiley +1 more source