Results 81 to 90 of about 63,423 (202)

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD-dependent enzymes

, 2004
Three novel dinucleotide analogues of nicotinamide adenine dinucleotide (NAD+) have been synthesised from -ribonolactone. These compounds incorporate a thiophene moiety in place of nicotinamide and are hydrolytically stable.
Migaud, Marie, Francesca Paradisi, Paradisis, F., Engel, P.C., Nathalie E Batoux, Marie E Migaud, Paul C Engel, Batoux, Nathalie   +7 more
core   +1 more source

Nicotinamide adenine dinucleotide as a photocatalyst [PDF]

, 2019
Nicotinamide adenine dinucleotide (NAD+) is a key redox compound in all living cells responsible for energy transduction, genomic integrity, life-span extension, and neuromodulation.
Caroline E. Paul, Frank Hollmann, Lee, Sahng, Paul, C.E. (author), Chan Beum Park, Lee, Sahng Ha (author), Kim, Jinhyun, Florian Tieves, Park, Chan, Hollmann, F. (author), Park, Chan Beum, Sahng Ha Lee, Lee, Sahng Ha, Hollmann, Frank, Tieves, F., Paul, C.E., Park, Chan Beum (author), Hollmann, F., Tieves, Florian, Kim, Jinhyun (author), Jinhyun Kim, Paul, Caroline, Tieves, F. (author)   +22 more
core   +2 more sources

Oxidative Stress in Human Aorta of Patients with Advanced Aortoiliac Occlusive Disease

Brazilian Journal of Cardiovascular Surgery
Introduction: Oxidative stress seems to be a role in the atherosclerosis process, but research in human beings is scarce. Objective: To evaluate the role of oxidative stress on human aortas of patients submitted to surgical treatment for advanced ...
Márcio Luís Lucas, Cristina Campos Carraro, Adriane Belló-Klein, Antonio Nocchi Kalil, Newton Aerts   +4 more
doaj   +1 more source

Nicotinamide adenine dinucleotide suppresses epileptogenesis at an early stage

Scientific Reports, 2017
The pathophysiologic mechanisms of epileptogenesis are poorly understood, and no effective therapy exists for suppressing epileptogenesis. Numerous reports have shown that nicotinamide adenine dinucleotide (NAD+) has neuroprotective effects, suggesting ...
Juan Liu, Beimeng Yang, Pei Zhou, Yingying Kong, Weiwei Hu, Geng Zhu, Weihai Ying, Weidong Li, Yun Wang, Shengtian Li   +9 more
doaj   +1 more source

Cloning, expression and characterization of alcohol dehydrogenases in the silkworm Bombyx mori

Genetics and Molecular Biology, 2011
Alcohol dehydrogenases (ADH) are a class of enzymes that catalyze the reversible oxidation of alcohols to corresponding aldehydes or ketones, by using either nicotinamide adenine dinucleotide (NAD) or nicotinamide adenine dinucleotide phosphate (NADP ...
Nan Wang, Haifeng Shi, Qin Yao, Yang Zhou, Lequn Kang, Huiqin Chen, Keping Chen   +6 more
doaj   +1 more source

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Spatially Informed Feature Selection and Machine Learning in Matrix‐Assisted Laser Desorption/Ionization Imaging for Cohort‐Scale Molecular Tissue Phenomics in Glioblastoma

Advanced Intelligent Discovery, EarlyView.
Matrix‐assisted laser desorption/ionization imaging‐based identification of reliable small molecule markers across heterogeneous glioblastoma cohorts is challenging with intensity‐only methods. We present spatially informed feature selection (SIFS), a spatially informed framework that prioritizes molecules consistently colocalizing with histopathology.
Shad A. Mohammed, Denis Abu Sammour, Dirk C. Hoffmann, Philipp Sievers, Tobias Bausbacher, Melissa Hahn, Yasemin Ucal, Iris Mildenberger, Christiane A. Opitz, Stefan Schmidt, Michael Platten, Oliver Wasenmüller, Wolfgang Wick, Andreas von Deimling, Tobias Kessler, Carsten Hopf   +15 more
wiley   +1 more source

Chemical synthesis of the second messenger nicotinic acid adenine dinucleotide phosphate by total synthesis of nicotinamide adenine dinucleotide phosphate.

, 2004
Signaling dinucleotides: The first single-isomer synthesis of nicotinamide adenine dinucleotide phosphate (NADP) is reported. Installation and maintenance of sensitive phosphate and pyridinium functionalities were key to success.
Moreau, C, Dowden, J, Brown, RS, Berridge, G, Potter, BV, Galione, A, Galione, Antony   +6 more
core   +1 more source

Relationship between nicotinamide adenine dinucleotide phosphate-diaphorase-reactive neurons and blood vessels in basal ganglia

, 1999
The relationship between nicotinamide adenine dinucleotide phosphate-diaphorase-positive neurons and blood vessels was investigated within the rat basal ganglia.
Kayalioglu, G, Govsa, F, G. Kayalioglu, F. Govsa   +3 more
core   +1 more source