Results 91 to 100 of about 63,423 (202)

Calcium transported to isolated rat liver nuclei by nicotinamide adenine dinucleotide is insensitive to thapsigargin [PDF]

, 1996
Calcium uptake by isolated nuclei was mediated by nicotinamide adenine dinucleotide. Oxidized nicotinamide nucleotide analogues were more effective mediators of nuclear calcium uptake. Thapsigargin inhibited ATP-mediated nuclear calcium transport without
Matter, N., Malviya, A.N., A.N. Malviya, N. Matter   +3 more
core   +1 more source

Escherichia coli Strain Designed for Characterizing in Vivo Functions of Nicotinamide Adenine Dinucleotide Analogues

, 2019
An Escherichia coli strain was constructed for the efficient import of nicotinamide adenine dinucleotide (NAD) analogues into cells by limiting extracellular degradation while expressing an efficient NAD importer. In vivo functions of three NAD analogues
Yuxue Liu, Yue Sun, Yuxue Liu (3742447), Dayu Yu (2792692), Wujun Liu (436564), Zongbao K. Zhao (436565), Dayu Yu, Bin Liu (5899), Yue Sun (197395), Lei Wang (6656), Lei Wang, Wujun Liu, Bin Liu, Zongbao K. Zhao   +13 more
core   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Efficient Nicotinamide Adenine Dinucleotide Phosphate [NADP(H)] Recycling in Closed‐Loop Continuous Flow Biocatalysis

, 2020
Biocatalytic redox reactions regularly depend on expensive cofactors that require recycling. For continuous conversions in flow chemistry, this is often an obstacle since the cofactor is washed away.
Jörg Pietruszka, Baumer, Benedikt, Classen, Thomas, Pohl, Martina, Martina Pohl, Pietruszka, Jörg, Benedikt Baumer, Thomas Classen   +7 more
core   +1 more source

Constant Illumination Boosts Rice Immunity via the Nicotinamide Mononucleotide Signaling Pathway: A Mechanistic Exploration

Rice
Light serves as a key input signal for the plant circadian clock, and together they coordinately regulate plant growth and development. However, the nature of their relationship regarding rice immunity remains unclear.
Mengyan Sun, Xinqing Wu, Kunying Ding, Lin Song, Mengying Zhou, Xiaoyan Su, Zhi Ye, Minghao Tang, Tao Lu, Haifeng Qian, Zhengwei Fu, Yinhua Ni   +11 more
doaj   +1 more source

Diphenyleneiodonium chloride synergizes with diazoxide to enhance protection against amyloid β induced neurotoxicity

Journal of Integrative Neuroscience, 2019
We examined synergistic effects of inhibiting reactive oxygen species generated from the mitochondria and from nicotinamide adenine dinucleotide phosphate oxidase on neurotoxicity. Primary hippocampal neurons were exposed to amyloid β, and the cells were
Qingxi Fu, Naiyong Gao, Fengyuan Che, Guangyin Xu, Hongxing Han, Quanping Su, Guozhao Ma   +6 more
doaj   +1 more source

Cross-tolerance between nitric oxide synthase inhibition and atypical antipsychotics modify nicotinamide-adenine-dinucleotide phosphate-diaphorase activity in mouse lateral striatum

, 2019
DigitalPrevious research indicates that the subchronic administration of NG-nitro-L-arginine (L-NOARG) produces tolerance to haloperidol-induced catalepsy in Swiss mice.
De Lima, Mairon O., Marcela B. Echeverry, Prieto, Sonia G., João C.S. Silva, Mairon O. de Lima, Silva, João C.S., Echeverry, Marcela B., Maria C. Almeida, Sonia G. Prieto, Almeida, Maria C.   +9 more
core   +1 more source

Dual compartment lipid carriers hijack exocytosis to empower natural killer cells against solid tumours

Nature Communications
Solid tumours resist adoptive cell therapies through lactate driven immunosuppression, which depletes intracellular nicotinamide adenine dinucleotide, suppresses interferon gamma production in T cells, and reprogrammes macrophages.
Shixin Chen, Zhenxuan Shao, Yijia Zhou, Yucheng Xue, Xupeng Chai, Lingxiao Jin, Haochen Mou, Xiao Ma, Teng Ma, Liang Chen, Xiayu Hu, Kelei Wang, Senxu Lu, Fangqian Wang, Shenzhi Zhao, Minjun Yao, Chengcheng Yu, Junjie Pan, Xiaohua Yu, Zhaoming Ye, Binghao Li   +20 more
doaj   +1 more source

Metabolomic investigation of cisplatin‐induced acute kidney injury in paediatric cancer patients

British Journal of Clinical Pharmacology, EarlyView.
Aim Cisplatin causes acute kidney injury (AKI) in approximately 46% of paediatric cancer patients who receive it. Serum creatinine (SCr) is a poor biomarker of cisplatin nephrotoxicity, because there is a delay between cisplatin infusion and SCr elevation.
Yong Jin Lim, Amy Thachil, Kelly McMahon, Ross T. Tsuyuki, S. Rod Rassekh, Lesley G. Mitchell, Prasad Devarajan, Cherry Mammen, Bruce C. Carleton, Geoffrey D. E. Cuvelier, Victor A. Lewis, Colin J. D. Ross, Alexandra P. Zorzi, Sylvain Baruchel, Raveena Ramphal, Eric Bouffet, Mathieu Lemaire, Tom D. Blydt‐Hansen, Brad L. Urquhart, The Applying Biomarkers to Minimize Long‐Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Research Study Group, Tom Blydt‐Hansen, Bruce C. Carleton, Geoff D. E. Cuvelier, Sunil Desai, Prasad Devarajan, Conrad Fernandez, Adam Fleming, Paul Gibson, Caroline Laverdiere, Victor Lewis, Mary L. McBride, Bruno Michon, Shahrad Rod Rassekh, Colin J. D. Ross, Christine Sabapathy, Kirk R. Schultz, Michael Zappitelli, Alexandra Zorzi   +37 more
wiley   +1 more source

254 - Effect of the Adenine Moiety on the Electrochemical Behavior of Nicotinamide Adenine Dinucleotide; Possible Reduction of the Adenine

, 1978
The presence of the adenine moiety very markedly affects the adsorption phenomena at the solution|electrode interface associated with nicotinamide adenine dinucleotide (NAD+) in aqueous media.
Schmakel, Conrad O., Elving, Philip Juliber, Jensen, Mark A.   +2 more
core   +1 more source