Results 91 to 100 of about 90,416 (304)

Circulating Amino Acid Network Remodeling Reveals Systemic Metabolic Reprogramming Predictive of Colorectal Cancer Recurrence and Metastasis

Advanced Science, EarlyView.
Blood‐based amino acid patterns measured by 19F NMR reveal hidden metabolic changes in colorectal cancer. By analyzing how these amino acids interact as a network, machine learning models identify patients at higher risk of recurrence and metastasis.
Ji‐Yeon Lee, Jumi Kim, Taehan Yoon, So Hyun Kwon, Su Chan Park, Dohyun Chun, Dohyeong Kim, Eun Jung Park, Hyunwoo Kim, Ji Min Lee   +9 more
wiley   +1 more source

Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD-dependent enzymes

, 2004
Three novel dinucleotide analogues of nicotinamide adenine dinucleotide (NAD+) have been synthesised from -ribonolactone. These compounds incorporate a thiophene moiety in place of nicotinamide and are hydrolytically stable.
Migaud, Marie, Francesca Paradisi, Paradisis, F., Engel, P.C., Nathalie E Batoux, Marie E Migaud, Paul C Engel, Batoux, Nathalie   +7 more
core   +1 more source

Review on Biosynthesis of β-Nicotinamide Mononucleotide and Its Derivatives [PDF]

Shipin Kexue
β-Nicotinamide mononucleotide (NMN) is present in all organisms and has attracted widespread attention as a nutritional supplement and pharmaceutical product for the treatment of various diseases, such as Alzheimer’s disease, cancer, aging, and vascular ...
WANG Zhaoying, GUO Xinhao, HUANG Xinhe, CHEN Zhuoyan, LIU Yueqi, LI Juan, CHEN Ning, FAN Xiaoguang
doaj   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

Tumor Microenvironment‐Responsive Nanoreactor Induces Disulfidptosis in Pancreatic Cancer via Metabolic Interference and Redox Catalysis

Advanced Science, EarlyView.
Schematic illustration of a tumor microenvironment‐responsive nanoreactor for imaging‐guided induction of disulfidptosis in pancreatic cancer via metabolic interference and redox catalysis. (A) Stepwise fabrication of Pht@HMnO2‐HA, including MnO2 growth on a SiO2 template, template removal to form hollow mesoporous MnO2, Pht loading, and subsequent ...
Rui Fu, Qing Li, Guanzhong Zhao, Qingyan Gao, Huantong Chen, Khemayanto Hidayat, Jiaying Xu, Liqiang Qin, Chunhong Hu, Yu Chong, Su Hu   +10 more
wiley   +1 more source

Relationship between nicotinamide adenine dinucleotide phosphate-diaphorase-reactive neurons and blood vessels in basal ganglia

, 1999
The relationship between nicotinamide adenine dinucleotide phosphate-diaphorase-positive neurons and blood vessels was investigated within the rat basal ganglia.
Kayalioglu, G, Govsa, F, G. Kayalioglu, F. Govsa   +3 more
core   +1 more source

Nicotinamide adenine dinucleotide suppresses epileptogenesis at an early stage

Scientific Reports, 2017
The pathophysiologic mechanisms of epileptogenesis are poorly understood, and no effective therapy exists for suppressing epileptogenesis. Numerous reports have shown that nicotinamide adenine dinucleotide (NAD+) has neuroprotective effects, suggesting ...
Juan Liu, Beimeng Yang, Pei Zhou, Yingying Kong, Weiwei Hu, Geng Zhu, Weihai Ying, Weidong Li, Yun Wang, Shengtian Li   +9 more
doaj   +1 more source

The processes of the catalytic cycle of the cytochrome system associated with its activation by means of the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase [PDF]

BIO Web of Conferences
The paper presents a theoretical study of the molecular mechanism of activation of the cytochrome P450 system by the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase in the catalytic cycle.
Popova Olga, Bylinskaya Daria, Nikitina Anastasia, Ukrainskaya Olga   +3 more
doaj   +1 more source

Insight into an Oxidative DNA-Cleaving DNAzyme: Multiple Cofactors, the Catalytic Core Map and a Highly Efficient Variant

iScience, 2020
Summary: An oxidative DNA-cleaving DNAzyme (PL) employs a double-cofactor model “X/Cu2+” for catalysis. Herein, we verified that reduced nicotinamide adenine dinucleotide (NADH), flavin mononucleotide, cysteine, dithiothreitol, catechol, resorcinol ...
Wenqian Yu, Shijin Wang, Dongling Cao, Hongyue Rui, Chengcheng Liu, Yongjie Sheng, Yanhong Sun, Jin Zhang, Jiacui Xu, Dazhi Jiang   +9 more
doaj   +1 more source

Spatially Informed Feature Selection and Machine Learning in Matrix‐Assisted Laser Desorption/Ionization Imaging for Cohort‐Scale Molecular Tissue Phenomics in Glioblastoma

Advanced Intelligent Discovery, EarlyView.
Matrix‐assisted laser desorption/ionization imaging‐based identification of reliable small molecule markers across heterogeneous glioblastoma cohorts is challenging with intensity‐only methods. We present spatially informed feature selection (SIFS), a spatially informed framework that prioritizes molecules consistently colocalizing with histopathology.
Shad A. Mohammed, Denis Abu Sammour, Dirk C. Hoffmann, Philipp Sievers, Tobias Bausbacher, Melissa Hahn, Yasemin Ucal, Iris Mildenberger, Christiane A. Opitz, Stefan Schmidt, Michael Platten, Oliver Wasenmüller, Wolfgang Wick, Andreas von Deimling, Tobias Kessler, Carsten Hopf   +15 more
wiley   +1 more source