Results 121 to 130 of about 142,436 (357)

Regulation of Peripheral Molecular Clocks in Mammalian Tissues and In Vitro Skeletal Muscle Activation of AMP-Activated Protein Kinase via AICAR

, 2014
Most organisms possess a common molecular machinery that governs cellular and tissue circadian rhythmicity through a roughly 24-hour transcription-translation feedback loop.
Brandauer, Josef, Lupolt, Alex C., Moorhead, Daniel P.   +2 more
core  

Reactive Oxygen Species and Endothelial Function – Role of Nitric Oxide Synthase Uncoupling and Nox Family Nicotinamide Adenine Dinucleotide Phosphate Oxidases [PDF]

, 2011
Augusto C. Montezano, Rhian M. Touyz
openalex   +1 more source

Electron‐Mediator‐Free Microfluidic Photocatalytic Coenzyme Regeneration with 100% Conversion Efficiency within 126 S

Advanced Science, EarlyView.
Discover a groundbreaking mediator‐free photocatalytic method for coenzyme NAD(P)H regeneration using BiOBr nanosheets in a microfluidic chip. This study achieves 100% NAD+ to NADH conversion in 126 s, maintaining >87% efficiency over 32 h. Explore how photocatalysis and microfluidics combine to offer a sustainable, scalable solution for green ...
Yao Chai, Liang Wan, Zirui Pang, Xu Li, Zixuan Jia, Heng Jiang, Chi Chung Tsoi, Huaping Jia, Jinni Shen, Zizhong Zhang, Jinlin Long, Fengjia Xie, Yanmei Chen, Xuming Zhang   +13 more
wiley   +1 more source

Model based study of autothermal thermophilic aerobic digestion (ATAD) processes : a thesis presented in partial fulfilment of the requirements for the degree of Master of Technology in Engineering and Automation of Massey University [PDF]

, 2000
An Autothermal Thermophilic Aerobic Digestion process, or ATAD process, is a relatively new sewage sludge treatment process. The ATAD process has been developed for the disinfection and stabilisation of sewage sludge, which is a by-product of wastewater ...
Fryer, Barry
core  

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Diphenyleneiodonium chloride synergizes with diazoxide to enhance protection against amyloid β induced neurotoxicity

Journal of Integrative Neuroscience, 2019
We examined synergistic effects of inhibiting reactive oxygen species generated from the mitochondria and from nicotinamide adenine dinucleotide phosphate oxidase on neurotoxicity. Primary hippocampal neurons were exposed to amyloid β, and the cells were
Qingxi Fu, Naiyong Gao, Fengyuan Che, Guangyin Xu, Hongxing Han, Quanping Su, Guozhao Ma   +6 more
doaj   +1 more source

The inhibition of pig kidney alkaline phosphatase by oxidized or reduced nicotinamide–adenine dinucleotide and related compounds [PDF]

, 1973
Indra Ramasamy, Peter Butterworth
openalex   +1 more source

Ir(III) Complexes Convert Cold to Hot Tumors via Ferroptosis/Necroptosis‐Driven Immunogenic Cell Death and Photosensitized CD47 Downregulation

Advanced Science, EarlyView.
Red‐light‐activated Ir1 overcomes hypoxia tolerance and adapts to the immunosuppressive tumor microenvironment, converting immunologically cold tumors into inflamed hot microenvironments. This conversion is driven by synergistic induction of immunogenic cell death through coordinated ferroptosis‐necroptosis pathways and spatiotemporally controlled ...
Long‐Bo Yu, Peng Wang, Qing‐Hua Shen, Qi‐Xin Guan, Zhi‐Yuan Li, Ying‐Ying Han, Xin‐Yi Zhang, Qing‐Yuan Hu, Cai‐Ping Tan   +8 more
wiley   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source