Results 141 to 150 of about 90,416 (304)

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source

Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration.

, 2017
UNLABELLED: The regenerative capacity of the liver is essential for recovery from surgical resection or injuries induced by trauma or toxins. During liver regeneration, the concentration of nicotinamide adenine dinucleotide (NAD) falls, at least in part ...
Chellappa, Karthikeyani, Moffitt, Andrea, Davis, James G, Mukherjee, Sarmistha, Baur, Joseph A, Agarwal, Beamon, MD, PhD, Dellinger, Ryan W, Ndungu, Joan   +7 more
core  

Synthesis and electrochemical behavior of triazole-containing nicotinamide adenine dinucleotide analogs

, 2010
The coupling of 2',3'-di-O-acetyl nicotinamide mononucleotide with 3-butyn-1-ol in the presence of 2,4,6-triisopropylbenzenesulfonyl chloride quantitatively afforded a terminal alkyne-containing intermediate.
Zhao, Zongbao Kent, Hou, Shuhua, Liu, Wujun   +2 more
core   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Multiple Forms of Nicotinamide Adenine Dinucleotide Glycohydrolase from Bull Semen

, 1980
Nicotinamide adenine dinucleotide glycohydrolase (NADase) of bull semen is an extracellular, soluble enzyme capable of catalyzing the hydrolysis of the nicotinamide N-ribosidic linkage of NAD+.
Yeatts, Stanley D., II
core   +1 more source

Targeting nicotinamide adenine dinucleotide biosynthesis to improve metabolism

Nicotinamide adenine dinucleotide (NAD) is a cellular metabolite that regulates many biological processes. NAD levels decline with age and also in obesity and interventions that increase NAD levels produce favourable metabolic effects.

core   +1 more source

Tissue-specific effects of bacterial PncA overexpression on NAD+ metabolism and aging in mice: implications for tissue-specific aging interventions

Frontiers in Aging
BackgroundAs a critical molecule in biological systems, nicotinamide adenine dinucleotide (NAD+) influences the aging of mammals. Therefore, regulation of NAD+ synthesis and degradation may slow aging and mitigate related diseases.ResultsThis study ...
Fengjiao Huo, Meili Zhao, Yue Liu, Shuyao Lv, Shengyu Feng, Liuling Guo, Nan Wang, Shuaishuai Zhang, Qing Liu, Taotao Mi, Hao Wang, Jian-Kang Zhu, Hailiang Liu, Hailiang Liu, Hailiang Liu   +14 more
doaj   +1 more source

Wearable biofluids colorimetric biosensors

FlexMat, EarlyView.
Wearable and flexible colorimetric sensors enable real‐time, non‐invasive detection through visible color changes. Advances in materials and device engineering have driven their development; however, challenges remain in sensitivity, selectivity, and scalable manufacturing.
Zhaoyuan Lyu, Zhiqiang Xiao, Wenhao Shen, Cheng Liu, Te Gu, Ruchuan Cao, Fangyu Zhang, Chuizhou Meng, Shichao Ding   +8 more
wiley   +1 more source

Fluorescence Properties of Carba Nicotinamide Adenine Dinucleotide for Glucose Sensing

, 2012
Carba nicotinamide adenine dinucleotide (cNAD) may serve as a stable cofactor for the enzyme‐based detection of glucose. Many characteristics of cNAD and its reduced form cNADH resemble those of NAD and NADH, respectively.
Herten, Dirk-Peter; id_orcid, von Ketteler, Alexa, Petrich, Wolfgang   +2 more
core   +1 more source

Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men

Endocrine Journal
Obesity and aging are major risk factors for several life-threatening diseases. Accumulating evidence from both rodents and humans suggests that the levels of nicotinamide adenine dinucleotide (NAD+), a regulator of many biological processes, declines in
Shintaro Yamaguchi, Junichiro Irie, Masanori Mitsuishi, Yuichi Uchino, Hideaki Nakaya, Ryo Takemura, Emi Inagaki, Shotaro Kosugi, Hideyuki Okano, Masato Yasui, Kazuo Tsubota, Kaori Hayashi, Jun Yoshino, Hiroshi Itoh   +13 more
doaj   +1 more source