Results 141 to 150 of about 63,423 (202)
Sensors, methods and kits for detecting nicotinamide adenine dinucleotides
The invention relates to the in vitro and in cellulo detection of the cofactors nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Provided is a sensor molecule for fluorescence or luminescence-based detection
Johnsson, Kai Peter +2 more
core
Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies
Medicinal Research Reviews, EarlyView.ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva +23 more
wiley +1 more source
Pediatric Discovery, EarlyView.Excessive neutrophil extracellular trap (NET) extrusion (NETosis) links prenatal inflammation to bronchopulmonary dysplasia (BPD) pathogenesis. Treatment with human umbilical cord mesenchymal stem cell‐derived microvesicles suppresses NET formation, reduces lung injury, and promotes alveolarization in a preterm rat model, offering a promising cell‐free
Yi Lu +10 more
wiley +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Hydrogen‐bond networks are central to protein function, but most network analyses rely on static representations that neglect how interactions evolve in time. Here, we introduce a framework that combines instantaneous and temporal graph analysis of hydrogen‐bond networks derived from molecular dynamics (MD) trajectories to quantify ligand ...
Tandac F. Guclu +2 more
wiley +1 more source
Nikotinamidmethylierung in normalen Geweben und Tumorzellen von Ratte und Maus [PDF]
, 1986 Seifert, Roland
core +1 more source
Pest Management Science, EarlyView.This study demonstrates that Brassica napus lines with Sinapis alba introgressions enhanced resistance against Phyllotreta cruciferae, resulting in reduced feeding damage and improved seedling physiological performance. The introgressed lines showed strong potential as genetic resources for developing more resilient and sustainable canola varieties ...
Aziz Ullah +4 more
wiley +1 more source
Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events
Phytotherapy Research, EarlyView.An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia +1 more
wiley +1 more source
Hypothalamic mechanisms of anti-obesity effect of nicotinamide adenine dinucleotide treatment
, 2017 Nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1 is an important regulator of hypothalamic neuronal function. Thus, adequate hypothalamic nicotinamide adenine dinucleotide (NAD) content has been reported to be critical for maintaining ...
노은
core
Photo‐responsive carbon dots for pyroptosis‐mediated anti‐tumor application
Responsive Materials, EarlyView.Photo‐responsive CDs generate ROS to induce tumor cell pyroptosis, thereby stimulating antitumor immunity. Abstract Pyroptosis refers to a kind of lytic programmed cell death, characterized by the release of pro‐inflammatory cytokines during the process. Owing to its immune response stimulation ability, pyroptosis has garnered considerable attention in
Lingyun Li +5 more
wiley +1 more source
Smart Molecules, EarlyView.Acidic pH triggers GOT1 phase separation via IDR1, recruiting ME1 to form ROS‐scavenging condensates that combat senescence, revealed by a FLIM‐based pH probe. Abstract Cellular senescence involves progressive acidification, but how cells sense and adapt to this pH shift remains unclear.
Ziyue Chen +8 more
wiley +1 more source