Results 151 to 160 of about 63,423 (202)

A dual‐responsive fluorescent probe for imaging viscosity and polarity in nonalcoholic fatty liver disease

Smart Molecules, EarlyView.
We developed a BODIPY‐based fluorescent probe with dual responsiveness to viscosity and polarity, enabling sensitive and precise imaging of non‐alcoholic fatty liver disease. Abstract Viscosity and polarity are critical physiological parameters implicated in the onset and progression of nonalcoholic fatty liver disease (NAFLD).
Di Zhao, Zhizhong Wang, Ke Xu, Yuntai Liu, Di Wu, Ting Jiang, Haonan Gao, Chengmei Xiao, Debin Zheng, Kai Wang, Wenhao Zhai   +10 more
wiley   +1 more source

pKa engineering of a near‐infrared fluorescent probe for sensitive imaging of oxidative stress in atherosclerotic plaques

Smart Molecules, EarlyView.
A pKa‐engineered near‐infrared fluorescent probe (DCM‐2F‐B) enables sensitive imaging of oxidative stress in atherosclerotic plaques. Difluoro substitution lowers the phenolic hydroxyl pKa from 9.1 to 6.0, achieving near‐complete ionization at physiological pH.
Qianqian Yu, Jiahui Liang, Tijian Zhou, Qiaomeng Chen, Xuechun Yan, Zhikang Zheng, Huyou Wang, Jihong Liu, Yi Dong, Wei‐Hong Zhu, Qi Wang   +10 more
wiley   +1 more source

Rotenone Induces Morphological Damage and Reduction in Catecholamine Levels in the Central Nervous System of the Ascidian Styela plicata

Environmental Toxicology, EarlyView.
ABSTRACT Ascidians are invertebrates that occupy a key phylogenetic position as a sister group of the vertebrates. The organization of their central nervous system (CNS), with cortex and medulla, indicates a plesiomorphic character of the gray and white matter of vertebrates, making this group of animals useful for studies of neurodegenerative events ...
Andressa de Abreu Mello, Carlos Augusto Borges de Andrade Gomes, Rafaela Rocha dos Santos, Cintia Monteiro de Barros, Silvana Allodi   +4 more
wiley   +1 more source

Advances in deep‐tissue fluorescence imaging through optical clearing: A review

VIEW, EarlyView.
Optical clearing refers to techniques that are used to improve the optical transparency of biological tissues. Optical clearing enables imaging of deeper lying tissues as well as 3D volumetric imaging of whole organs. This review examines reports on the integration of optical clearing with advanced fluorescence imaging techniques, with particular ...
Alaka Pramod, Sanoop Pavithran M, Valery V. Tuchin, Santhosh Chidangil, C. S. Suchand Sandeep   +4 more
wiley   +1 more source

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou, Shi Luo, Yu Xiao, Bin Liu, Xu‐Ping Xiao   +4 more
wiley   +1 more source

Monitoring Mitochondrial Function With High‐Resolution Respirometry During Ex‐Situ Heart Perfusion

Artificial Organs, EarlyView.
Normothermic ESHP preserves mitochondrial respiratory function over 6 h in a porcine model (n = 6): OXPHOS capacities across NADH‐, fatty‐acid‐, and succinate‐linked pathways remain stable, with reduced cytochrome‐c control efficiency indicating improved outer‐membrane integrity. HRR provides a rapid, actionable readout for organ assessment.
Lukas Stastny, Julia Hofmann, Andras T. Meszaros, Alexandra Ampferer, Gabriel Putzer, Nina Perkins, Natalie Huemer, Florian Sommerauer, Judith Martini, Julian Wagner, Michael Grimm, Stefan Schneeberger, Julia Dumfarth   +12 more
wiley   +1 more source

Dystrophia Smolandiensis is characterized by a novel NQO1 variant and a distinct phenotype from COL17A1‐associated epithelial recurrent erosion dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To determine the molecular cause of the two epithelial recurrent erosion dystrophies, Dystrophia Smolandiensis and Dystrophia Helsinglandica, and to identify phenotypic differences between the two conditions. Methods DNA samples and clinical data from structured interview records were obtained from the Swedish families in which ...
Karl De Geer, Kristina Lagerstedt‐Robinson, Daniel Nilsson, Cilla Söderhäll, Björn Hammar, Erik Björck   +5 more
wiley   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Metabolic remodelling in anthracycline cardiotoxicity: mechanisms and therapeutic insights

British Journal of Pharmacology, EarlyView.
Cardiac metabolic remodelling in anthracycline‐induced cardiomyopathy and metabolically oriented cardioprotective strategies. Schematic representation of substrate utilization, mitochondrial bioenergetic function and metabolic flexibility in the healthy heart, in anthracycline‐induced cardiomyopathy and under potential cardioprotective interventions ...
Giulia Guerra, Francesco Niro, Marco Mergiotti, Giovanni Gavatorta, Emilio Hirsch, Alessandra Ghigo   +5 more
wiley   +1 more source