Results 161 to 170 of about 90,416 (304)

Acute Modafinil Exposure Induces Neurobehavioral Alterations in Zebrafish: Implications for Off‐Label Cognitive Enhancement

Journal of Applied Toxicology, EarlyView.
ABSTRACT Modafinil (2‐(benzhydrylsulfinyl)acetamide) is a psychostimulant commonly prescribed for sleep disorders such as narcolepsy, excessive daytime sleepiness, and obstructive sleep apnea. Recently, its use has extended beyond clinical indications, with neurotypical individuals adopting it as a smart drug to enhance alertness and cognitive ...
Luciane Dellazari da Silva do Prado, Nicole Berton, Nicoli da Rosa Amaral, Inara Carbonera Biazus, Laíse Mattiollo, Jéssica Nardi, Karen Júlia de Souza dos Santos, Natália Freddo, Leonardo José Gil Barcellos, Luciana Grazziotin Rossato‐Grando   +9 more
wiley   +1 more source

Comparison Between Respiratory‐Triggered and Free‐Breathing Signal Acquisition Methods for Single‐Voxel Phosphorus Magnetic Resonance Spectroscopy of the Liver on a Clinical System

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background The optimal protocol for clinical liver 31P‐magnetic resonance spectroscopy (MRS) remains unclear. Single‐voxel 31P‐MRS using image‐selected in vivo spectroscopy (ISIS) employs respiratory‐triggering (RT) or free‐breathing (FB) acquisition.
Kumi Ozaki, Jihun Kwon, Marc Van Cauteren, Yasutomo Katsumata, Yukichi Tanahashi, Satoshi Goshima   +5 more
wiley   +1 more source

Metabolic and Volumetric Alterations in the Basal Ganglia and the Cerebellum in Dopa‐Responsive Dystonia in Symptomatic and Asymptomatic GCH1 Mutation Carriers

Movement Disorders, EarlyView.
ABSTRACT Background Dopa‐responsive dystonia is caused by pathogenic variants in the GCH1 gene. Although its clinical features and reduced penetrance are known, in vivo metabolic and structural alterations in symptomatic (sMC) and asymptomatic mutation carriers (aMC) remain poorly understood.
Jannik Prasuhn, Leon van Well, Marta M. Pokotylo, Feline Hamami, Joke‐Lina Aßmann, Katja Lohmann, Maximilian G. Ködderitzsch‐Mertins, Julia Henkel, Jan Uter, Alexander Münchau, Christine Klein, Anne Weissbach, Norbert Brüggemann   +12 more
wiley   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Structured Electrodes Enable High-Rate and Selective Electrochemical Nicotinamide Adenine Dinucleotide Regeneration for Biocatalysis. [PDF]

ChemSusChem
Wolf J, Goy R, Medlock JA, Kleinhaus JT, Pellumbi K, Wickert L, Siegmund D, Apfel UP.   +7 more
europepmc   +1 more source

Lactate Dehydrogenase A and a Novel Four‐Gene Signature as Dual Diagnostic Markers for Lung Adenocarcinoma and Ischemic Stroke

Medicine Advances, EarlyView.
This study identified shared molecular alterations between lung adenocarcinoma (LUAD) and ischemic stroke (IS) through integrative transcriptomic analysis of TCGA‐LUAD and GSE146882 datasets, revealing a four‐gene diagnostic signature (LDHA, NME4, SLC25A39, and SLC7A5) with high accuracy across both diseases. Among these, LDHA was further identified as
Jin Xie, Gao‐Chun Xiao, Xin‐Yang Qu, Rui‐Min Wu, Yu‐Long Zou, Xue Hu, Xu‐Sheng Liu   +6 more
wiley   +1 more source

Potent Neuronal Nicotinamide Adenine Dinucleotide-Boosting Tetrahydroquinoxalines: Structure-Activity Relationships and Early Drug Metabolism and Pharmacokinetics Evaluation. [PDF]

ACS Med Chem Lett
Cuřínová P, Jöe M, Cesar F, Nicol A, Schwan K, Kohout M, Varrichio C, Saleh A, Wheelock CE, Jóhannesson G, Eigner V, Tribble JR, Brancale A, Williams PA.   +13 more
europepmc   +1 more source

Deciphering the soybean root rot pathogen Phytophthora sojae: Signaling pathways, transcriptional regulation, and effector biology

New Plant Protection, EarlyView.
This review highlights how Phytophthora sojae utilizes unconventional lineage‐specific signaling networks, including unique G protein‐coupled receptor fusions, expanded kinases, and rapidly evolving effectors, to infect soybeans. Understanding these divergent molecular paradigms reveals critical vulnerabilities in this destructive pathogen, offering ...
Min Qiu, Xiaoyi Zhang, Bo Yang, Wenwu Ye, Yuanchao Wang   +4 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Starving leukemia: nicotinamide phosphoribosyltransferase-dependent nicotinamide adenine dinucleotide salvage links metabolic vulnerability to therapeutic sensitivity in acute myeloid leukemia. [PDF]

Transl Cancer Res
Coelho-Silva JL, Pereira-Martins DA, Machado-Neto JA.   +2 more
europepmc   +1 more source