Results 11 to 20 of about 51,366 (193)

Structural Basis of Beneficial Design for Effective Nicotinamide Phosphoribosyltransferase Inhibitors [PDF]

Molecules, 2020
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) is an attractive therapeutic strategy for targeting cancer metabolism. So far, many potent NAMPT inhibitors have been developed and shown to bind to two unique tunnel-shaped cavities existing ...
Sei-ichi Tanuma, Kiyotaka Katsuragi, Takahiro Oyama, Atsushi Yoshimori, Yuri Shibasaki, Yasunobu Asawa, Hiroaki Yamazaki, Kosho Makino, Miwa Okazawa, Yoko Ogino, Yoshimi Sakamoto, Miyuki Nomura, Akira Sato, Hideaki Abe, Hiroyuki Nakamura, Hideyo Takahashi, Nobuhiro Tanuma, Fumiaki Uchiumi   +17 more
doaj   +4 more sources

A Humanized Monoclonal Antibody Targeting Extracellular Nicotinamide Phosphoribosyltransferase Prevents Aggressive Prostate Cancer Progression. [PDF]

Pharmaceuticals (Basel), 2021
Prostate cancer (PCa) is the major cause of cancer-related death in males; however, effective treatments to prevent aggressive progression remain an unmet need.
Sun BL, Tang L, Sun X, Garcia AN, Camp SM, Posadas E, Cress AE, Garcia JGN.   +7 more
europepmc   +4 more sources

Nicotinamide Phosphoribosyltransferase-elevated NAD⁺ biosynthesis prevents muscle disuse atrophy by reversing mitochondrial dysfunction. [PDF]

J Cachexia Sarcopenia Muscle, 2023
It is well known that muscle disuse atrophy is associated with mitochondrial dysfunction, which is implicated in reduced nicotinamide adenine dinucleotide (NAD+) levels.
Zhang Y, Wang Y, Lu S, Zhong R, Liu Z, Zhao Q, Wang C.   +6 more
europepmc   +2 more sources

Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. [PDF]

Biochemistry, 2023
In aging and disease, cellular nicotinamide adenine dinucleotide (NAD+) is depleted by catabolism to nicotinamide (NAM). NAD+ supplementation is being pursued to enhance human healthspan and lifespan. Activation of nicotinamide phosphoribosyltransferase (
Ratia KM, Shen Z, Gordon-Blake J, Lee H, Laham MS, Krider IS, Christie N, Ackerman-Berrier M, Penton C, Knowles NG, Musku SR, Fu J, Velma GR, Xiong R, Thatcher GRJ.   +14 more
europepmc   +2 more sources

Synthesis, Optimization, and Structure-Activity Relationships of Nicotinamide Phosphoribosyltransferase (NAMPT) Positive Allosteric Modulators (N-PAMs). [PDF]

J Med Chem, 2023
Depletion of nicotinamide adenine dinucleotide (NAD+) is associated with aging and disease, spurring the study of dietary supplements to replenish NAD+.
Shen Z, Ratia K, Krider I, Ackerman-Berrier M, Penton C, Musku SR, Gordon-Blake JM, Laham MS, Christie N, Ma N, Fu J, Xiong R, Courey JM, Velma GR, Thatcher GRJ.   +14 more
europepmc   +2 more sources

Extracellular Nicotinamide Phosphoribosyltransferase as a Surrogate Marker of Prominent Malignant Potential in Colonic Polyps: A 2-Year Prospective Study. [PDF]

Cancers (Basel), 2023
Simple Summary The implications of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) in colonic polyps remain uncertain. A 2-year prospective cohort study was conducted.
Chen TH, Hsu HC, You JF, Lai CC, Tsou YK, Hsu CL, Fann CSJ, Chien RN, Chang ML.   +8 more
europepmc   +2 more sources

Nicotinamide phosphoribosyltransferase prompts bleomycin-induced pulmonary fibrosis by driving macrophage M2 polarization in mice. [PDF]

Theranostics
Rationale: Idiopathic pulmonary fibrosis (IPF) is an irreversible, fatal interstitial lung disease lacking specific therapeutics. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of the nicotinamide adenine dinucleotide (NAD ...
Chen Y, Wang T, Liang F, Han J, Lou Z, Yu Y, Li J, Zhan T, Gu Y, Dong L, Jiang B, Zhang W, Wu M, Lu Y.   +13 more
europepmc   +2 more sources

Extracellular nicotinamide phosphoribosyltransferase visfatin activates JAK2-STAT3 pathway in cancer-associated fibroblasts to promote colorectal cancer metastasis. [PDF]

Genes Genomics
Metastasis is one of the major challenges in the treatment of colorectal cancer (CRC), during which cancer-associated fibroblasts (CAFs) in the tumor microenvironment are critically involved.
Lei Y, Shu D, Xia J, Zhang T, Wei H.
europepmc   +2 more sources

Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress. [PDF]

ACS Med Chem Lett
Evidence supports boosting nicotinamide adenine dinucleotide (NAD+) to counteract oxidative stress in aging and neurodegenerative disease. One approach is to enhance the activity of nicotinamide phosphoribosyltransferase (NAMPT).
Gordon-Blake J, Ratia K, Weidig V, Velma GR, Ackerman-Berrier M, Penton C, Musku SR, Alves ETM, Driver T, Tai L, Thatcher GRJ.   +10 more
europepmc   +2 more sources

Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype. [PDF]

Front Endocrinol (Lausanne), 2022
Cellular senescence is a stress or damage response by which a cell adopts of state of essentially permanent proliferative arrest, coupled to the secretion of a number of biologically active molecules. This senescence-associated secretory phenotype (SASP)
Kuehnemann C, Hu KQ, Butera K, Patel SK, Bons J, Schilling B, Aguayo-Mazzucato C, Wiley CD.   +7 more
europepmc   +2 more sources