Results 11 to 20 of about 6,777 (132)

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Nicotinamide phosphoribosyltransferase leukocyte overexpression in Graves’ opthalmopathy [PDF]

Endocrine, 2016
To investigate the role of NAMPT/visfatin in euthyroid patients with Graves' disease without (GD) and with Graves' ophthalmopathy (GO), we analyzed NAMPT leukocyte expression and its serum concentration. This was a single-center, cross-sectional study with consecutive enrollment.
Sawicka-Gutaj, Nadia, Budny, Bartłomiej, Zybek-Kocik, Ariadna, Sowiński, Jerzy, Ziemnicka, Katarzyna, Waligórska-Stachura, Joanna, Ruchała, Marek   +6 more
openaire   +2 more sources

Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine [PDF]

British Journal of Pharmacology, 2016
AbstractIn this review, we focus on the secreted form of nicotinamide phosphoribosyltransferase (NAMPT); extracellular NAMPT (eNAMPT), also known as pre‐B cell colony‐enhancing factor or visfatin. Although intracellular NAMPT is a key enzyme in controlling NAD metabolism, eNAMPT has been reported to function as a cytokine, with many roles in physiology
Ambra A Grolla, Cristina Travelli, Armando A Genazzani, Jaswinder K Sethi   +3 more
openaire   +5 more sources

The Role of Nicotinamide Phosphoribosyltransferase in Cerebral Ischemia [PDF]

Current Topics in Medicinal Chemistry, 2015
As recombinant tissue plasminogen activator is the only drug approved for the clinical treatment of acute ischemic stroke, there is an urgent unmet need for novel stroke treatments. Endogenous defense mechanisms against stroke may hold the key to new therapies for stroke.
Xinzhi, Chen, Shangfeng, Zhao, Yang, Song, Yejie, Shi, Rehana K, Leak, Guodong, Cao   +5 more
openaire   +2 more sources

Extension of Human Cell Lifespan by Nicotinamide Phosphoribosyltransferase [PDF]

Journal of Biological Chemistry, 2007
Extending the productive lifespan of human cells could have major implications for diseases of aging, such as atherosclerosis. We identified a relationship between aging of human vascular smooth muscle cells (SMCs) and nicotinamide phosphoribosyltransferase (Nampt/PBEF/Visfatin), the rate-limiting enzyme for NAD+ salvage from nicotinamide.
Eric, van der Veer, Cynthia, Ho, Caroline, O'Neil, Nicole, Barbosa, Robert, Scott, Sean P, Cregan, J Geoffrey, Pickering   +6 more
openaire   +2 more sources

The Cytokine Nicotinamide Phosphoribosyltransferase (eNAMPT

Cells, 2020
(1) Background: Extracellular nicotinamide phosphoribosyltrasferase (eNAMPT) is released by various cell types with pro-tumoral and pro-inflammatory properties. In cancer, eNAMPT regulates tumor growth through the activation of intracellular pathways, suggesting that it acts through a putative receptor, although its nature is still elusive. It has been
Torretta, Colombo, Travelli, Boumya, Lim, Genazzani, Grolla   +6 more
openaire   +1 more source

The function of nicotinamide phosphoribosyltransferase in the heart [PDF]

DNA Repair, 2014
In addition to its roles as a coenzyme and an electron transfer molecule, nicotinamide adenine dinucleotide (NAD+) has emerged as a substrate of sirtuins, a family of enzymes that control aging and metabolism. Nicotinamide phosphoribosyltransferase (Nampt), a rate-limiting enzyme in the NAD+ salvage pathway, plays an important role in controlling the ...
Chiao-Po, Hsu, Takanobu, Yamamoto, Shinichi, Oka, Junichi, Sadoshima   +3 more
openaire   +2 more sources

Regenerative Neurogenesis After Ischemic Stroke Promoted by Nicotinamide Phosphoribosyltransferase–Nicotinamide Adenine Dinucleotide Cascade [PDF]

Stroke, 2015
Background and Purpose— Nicotinamide adenine dinucleotide (NAD) is a ubiquitous fundamental metabolite. Nicotinamide phosphoribosyltransferase (Nampt) is the rate-limiting enzyme for mammalian NAD salvage synthesis and has been shown to protect against acute ischemic stroke.
Yan, Zhao, Yun-Feng, Guan, Xiao-Ming, Zhou, Guo-Qiang, Li, Zhi-Yong, Li, Can-Can, Zhou, Pei, Wang, Chao-Yu, Miao   +7 more
openaire   +2 more sources

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, EarlyView.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source

Nicotinamide Phosphoribosyltransferase Inhibitors

, 2012
Nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate (PRPP) to yield nicotinamide mononucleotide (NMN), a rate limiting enzyme in a mammalian salvage pathway of nicotinamide adenine dinucleotide (NAD) synthesis.
Wu, Dan, Cheranova, Dilyara, Heruth, Daniel P., Zhang, Li Qin, Ye, Shui Qing   +4 more
openaire   +3 more sources