Results 51 to 60 of about 32,759 (195)
Synthesizing and salvaging NAD: lessons learned from Chlamydomonas reinhardtii.
PLoS Genetics, 2010 The essential coenzyme nicotinamide adenine dinucleotide (NAD+) plays important roles in metabolic reactions and cell regulation in all organisms. Bacteria, fungi, plants, and animals use different pathways to synthesize NAD+.
Huawen Lin, Alan L Kwan, Susan K Dutcher
doaj +1 more source
, 2013 Nicotinamide adenine dinucleotide (NAD+) biosynthesis from nicotinamide is used by mammalian cells to replenish their NAD+ stores and to avoid unwanted nicotinamide accumulation. Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT)
Nahimana, A. +9 more
core +2 more sources
NAD+ metabolism controls inflammation during senescence
Molecular & Cellular Oncology, 2019 We have recently discovered that nicotinamide adenine dinucleotide metabolism controls the pro-inflammatory senescence-associated secretory phenotype during cellular senescence.
Timothy Nacarelli, Rugang Zhang
doaj +1 more source
Extension of Human Cell Lifespan by Nicotinamide Phosphoribosyltransferase [PDF]
Journal of Biological Chemistry, 2007 Extending the productive lifespan of human cells could have major implications for diseases of aging, such as atherosclerosis. We identified a relationship between aging of human vascular smooth muscle cells (SMCs) and nicotinamide phosphoribosyltransferase (Nampt/PBEF/Visfatin), the rate-limiting enzyme for NAD+ salvage from nicotinamide.
Eric, van der Veer +6 more
openaire +2 more sources
Endocrine Regulations, 2020 Objective. The aim of the present study was to investigate the effect of adipokine NAMPT (nicotinamide phosphoribosyltransferase) silencing on the expression of genes encoding IRS1 (insulin receptor substrate 1) and some other proliferation related ...
Tsymbal Daria O. +5 more
doaj +1 more source
Nicotinamide phosphoribosyltransferase leukocyte overexpression in Graves’ opthalmopathy [PDF]
Endocrine, 2016 To investigate the role of NAMPT/visfatin in euthyroid patients with Graves' disease without (GD) and with Graves' ophthalmopathy (GO), we analyzed NAMPT leukocyte expression and its serum concentration. This was a single-center, cross-sectional study with consecutive enrollment.
Sawicka-Gutaj, Nadia +6 more
openaire +2 more sources
Chemical structure of the nicotinamide phosphoribosyltransferase inhibitor APO866.
, 2013 Chemical structure of the nicotinamide phosphoribosyltransferase inhibitor APO866.
Mette Munk Jensen (109127) +9 more
core +1 more source
, 2013 Nicotinamide phosphoribosyltransferase (Nampt) is a key enzyme for nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, and recent evidence indicates its role in inflammatory processes.
Lenglet, Sébastien +25 more
core +1 more source
Cloning, expression, purification and drug targeting of Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase (HGXPRT) [PDF]
, 2005 Includes bibliographical references.The research concerns sub-cloning the gene for HGXPRT from Plasmodium falciparum from a vector with a His-tag facility to one without, expression of the protein in E. coli, and purification.
Mbewe, Boniface
core +1 more source
Nicotinamide Phosphoribosyltransferase in Sepsis
, 2012 The word sepsis was derived from the Greek word: sepsis, which means the state of putrefaction or decay. Sepsis is a potentially deadly medical condition that is characterized by a whole-body inflammatory state, called a systemic inflammatory response syndrome, and the presence of a known or suspected infection.
Peixin Huang +5 more
openaire +2 more sources