Results 61 to 70 of about 51,366 (193)

Disruption of Gut Microbiota‐Mediated De Novo NAD+ Synthesis Contributes to the Development of Polycystic Ovary Syndrome

Advanced Science, EarlyView.
This study demonstrates that patients with PCOS exhibit altered gut microbial profiles, and FMT from PCOS patients induces PCOS‐like symptoms in mice. Specifically, gut dysbiosis reduces 3‐HAA levels in the context of PCOS. Administration of 3‐HAA to mice alleviates PCOS by promoting de novo NAD+ synthesis.
Ke Chen, Huafeng Geng, Yang Zheng, Hongyang Xie, Rui Qin, Junyang Chen, Cong Ye   +6 more
wiley   +1 more source

Metabolic Changes in Living Human Lymphoma Cells Intervening NAD+ Metabolism as Revealed by NAD(P)H‐Fluorescence Lifetime Imaging and Para‐Hydrogen‐Induced Polarization NMR

Cytometry Part A, EarlyView.
ABSTRACT Proliferating cells have a sustained high demand for regeneration of electron acceptors as nicotinamide dinucleotide (phosphate) (NAD(P)+/NAD(P)H) is involved in a number of critical redox reactions within cells. However, their analysis in living cells is still challenging.
Lea Marie Jeude, Ruth Leben, Wiebke Beninga, Yonghong Ding, Gabriele Stevanato, Stefan Glöggler, Raluca A. Niesner, Dieter Kube   +7 more
wiley   +1 more source

Boosting NAD+ with a small molecule that activates NAMPT

Nature Communications, 2019
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate determining step for NAD+ synthesis and is of interest as a drug target. Here the authors identify and characterize a small molecule NAMPT activator SBI-797812, elucidate its mode of ...
Stephen J. Gardell, Meghan Hopf, Asima Khan, Mauro Dispagna, E. Hampton Sessions, Rebecca Falter, Nidhi Kapoor, Jeanne Brooks, Jeffrey Culver, Chris Petucci, Chen-Ting Ma, Steven E. Cohen, Jun Tanaka, Emmanuel S. Burgos, Jennifer S. Hirschi, Steven R. Smith, Eduard Sergienko, Anthony B. Pinkerton   +17 more
doaj   +1 more source

Metabolic engineering of Escherichia coli for biosynthesis of β‐nicotinamide mononucleotide from nicotinamide

Microbial Biotechnology, 2021
Summary The β‐nicotinamide mononucleotide (NMN) is a key intermediate of an essential coenzyme for cellular redox reactions, NAD. Administration of NMN is reported to improve various symptoms, such as diabetes and age‐related physiological decline. Thus,
Yang Liu, Montri Yasawong, Bo Yu
doaj   +1 more source

Ability of metformin to deplete NAD+ contributes to cancer cell susceptibility to metformin cytotoxicity and is dependent on NAMPT expression

Frontiers in Oncology, 2023
BackgroundNicotinamide adenine dinucleotide (NAD+) is vital for not only energy metabolism but also signaling pathways. A major source of NAD+ depletion is the activation of poly (ADP-ribose) polymerase (PARP) in response to DNA damage.
Yongxian Zhuang, Allison B. Haugrud, Meg A. Schaefer, Meg A. Schaefer, Shanta M. Messerli, W. Keith Miskimins   +5 more
doaj   +1 more source

Breast Milk Proteome: Changes in the Different Stages of Lactation and Impacts of Gestational Diabetes Mellitus and Body Mass Index

Molecular Nutrition &Food Research, EarlyView.
We analyzed colostrum and breast milk from 47 mothers to see how proteins change over time and with maternal health. Colostrum had more immune proteins, while mature milk had proteins linked to growth support. Gestational diabetes and higher BMI altered the protein composition.
Timo Seitz, Jenni Viitaharju, Chouaib Benchraka, Johannes Merilahti, Marko Kalliomäki, Lauri Polari, Diana Toivola, Leo Lahti, Otto Kauko, Kirsi Laitinen   +9 more
wiley   +1 more source

A Global Transcriptomic Analysis Reveals Body Weight‐Specific Molecular Responses to Chronic Orange Juice Consumption in Healthy Individuals

Molecular Nutrition &Food Research, EarlyView.
This study aimed to investigate the molecular pathways involved in the health benefits of chronic orange juice (OJ) consumption through global transcriptomic approach in peripheral blood mononuclear cells (PBMCs). Healthy volunteers consumed 500 mL of OJ daily for 60 days.
Layanne Nascimento Fraga, Dragan Milenkovic, Isabella de Araújo Esteves Duarte, Saivageethi Nuthikattu, Camille Perella Coutinho, Franco Maria Lajolo, Neuza Mariko Aymoto Hassimotto   +6 more
wiley   +1 more source

Nicotinamide mononucleotide production by fructophilic lactic acid bacteria

Scientific Reports, 2021
Nicotinamide mononucleotide (NMN), an intermediate in nicotinamide adenine dinucleotide biosynthesis, is recently attracting much attention for its pharmacological and anti-aging efficacies.
Kazane Sugiyama, Kana Iijima, Miyako Yoshino, Hideo Dohra, Yuji Tokimoto, Koji Nishikawa, Hideaki Idogaki, Nobuyuki Yoshida   +7 more
doaj   +1 more source

Proteomic Changes in Cancer Cell Lines as a Result of Bacterial Infection

PROTEOMICS, EarlyView.
ABSTRACT Bacterial infections have been implicated in shaping the tumor microenvironment (TME), but their effects on cancer cell proteomes remain unexplored. In this study, we analyzed proteomic changes in melanoma (A375) and ovarian cancer (OVCAR3) cell line models following infection with Staphylococcus aureus strain USA300 or Salmonella enterica ...
Bo Ren, Kenneth Weke, Darryl Hardie, Mariya I. Goncheva, Ted Hupp, Javier Antonio Alfaro, Helena Pětrošová, David R. Goodlett   +7 more
wiley   +1 more source

NAMPT and NAPRT, Key Enzymes in NAD Salvage Synthesis Pathway, Are of Negative Prognostic Value in Colorectal Cancer

Frontiers in Oncology, 2019
Nicotinamide adenine dinucleotide (NAD) is a profoundly important cofactor in redox reactions. Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT) are key enzymes for NAD salvage biosynthesis pathway, which ...
Xiao-qin Li, Jing Lei, Lin-hong Mao, Qing-liang Wang, Feng Xu, Tao Ran, Zhi-hang Zhou, Song He   +7 more
doaj   +1 more source