Results 81 to 90 of about 51,366 (193)

Tryptophan derivatives as non‐invasive diagnostic indicators for obesity‐related MASLD in children and adolescents

Diabetes, Obesity and Metabolism, Volume 27, Issue 12, Page 7544-7560, December 2025.
Abstract Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) represents a major health burden in children and adolescents with obesity. This study aimed to characterize metabolic alterations associated with obesity‐related MASLD and to evaluate the potential of tryptophan (TRP)‐derived metabolites as non‐invasive biomarkers for early ...
Shumin Zhan, Xingyun Wang, Chen Wang, Bowen Zhu, Jianfang Gao, Zhou Peng, Rui Wang, Yun Yang, Liang Zhang, Tengfei Wang, Jiaoxiang Wu, Wei Wu, Ke Huang, Guanping Dong, Qiannan Ren, Shan Wang, Senjie Wang, Xuelian Zhou, Liling Xu, Junfen Fu, Xirong Guo   +20 more
wiley   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, Volume 599, Issue 21, Page 3150-3162, November 2025.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Altered nicotinamide adenine dinucleotide metabolism drives cartilage degeneration and osteoarthritis

Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
PARP14 is upregulated in OA cartilage and contributes to NAD⁺ depletion. PARP14 silencing restores NAD⁺ levels and represses OA‐related metabolic and matrix‐degrading changes. NAD⁺ precursor treatment and NMNAT1 overexpression protect against cartilage degeneration in aging and post‐traumatic OA models.
Xiaoxin Wu, Xiwei Fan, Manuel Plan, Terra Stark, Tim McCubbin, Roberto A. Barrero, Maria Marinova, Michael J. Bertoldo, Dale M. Goss, Lindsay E. Wu, Ross Crawford, Xinzhan Mao, Indira Prasadam   +12 more
wiley   +1 more source

The Effect of Caffeine on Wnt/β‐Catenine and P38 Mitogen‐Activated Protein Kinases (MAPK) Signal Pathways and Some Biochemical Parameters on Cafeteria Diet in Rats

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
In this article, the effect of the cafeteria diet on obesity formation and the effect of caffeine on obesity recovery are explained through various signaling pathways and hormones. ABSTRACT Obesity is a major noncommunicable public health problem that is rapidly spreading worldwide, arising from an imbalance between energy intake and expenditure, and ...
Lale Baser, Emine Atakisi
wiley   +1 more source

Function of NAD metabolism in white adipose tissue: lessons from mouse models

Adipocyte
Nicotinamide Adenine Dinucleotide (NAD) is an endogenous substance in redox reactions and regulates various functions in metabolism. NAD and its precursors are known for their anti-ageing and anti-obesity properties and are mainly active in the liver and
So Young Kwon, Yoon Jung Park
doaj   +1 more source

Genistein enhances NAD⁺biosynthesis by binding to Prohibitin 1 and upregulating nicotinamide phosphoribosyltransferase in adipocytes [PDF]

, 2023
Shun Watanabe, Riki Haruyama, Koji Umezawa, Ikuo Tomioka, Soichiro Nakamura, Shigeru Katayama, Takakazu Mitani   +6 more
openalex   +1 more source

Vascular Endothelial NAMPT‐Mediated NAD+ Biosynthesis Regulates Angiogenesis and Cardiometabolic Functions in Male Mice

Aging Cell, Volume 24, Issue 11, November 2025.
Using male vascular endothelial cell–specific Nampt knockout and naturally aged mice, we identified endothelial NAD+ deficiency as a central driver of age‐related angiogenic failure, impaired subcutaneous adipogenesis, and cardiometabolic dysfunction.
Shotaro Kosugi, Shintaro Yamaguchi, Ken Nishioka, Taichi Nagahisa, Yasuhiro Watanabe, Daiki Kojima, Kenji Kaneko, Ryunosuke Mitsuno, Ran Nakamichi, Yoshinaga Kawano, Kenichiro Kinouchi, Koichiro Homma, Takeshi Kanda, Junichiro Irie, Kazutoshi Miyashita, Toshiaki Monkawa, Jun Yoshino, Hiroshi Itoh, Kaori Hayashi   +18 more
wiley   +1 more source

AMPK/SIRT1/PGC‐1α Signaling Pathway: Molecular Mechanisms and Targeted Strategies From Energy Homeostasis Regulation to Disease Therapy

CNS Neuroscience &Therapeutics, Volume 31, Issue 11, November 2025.
The AMPK/SIRT1/PGC‐1α signaling axis integrates energy sensing, epigenetic regulation, and mitochondrial biogenesis to maintain cellular homeostasis. Dysregulation of this pathway is related to neurodegenerative, metabolic, and cardiovascular diseases, highlighting its potential as a multifaceted therapeutic target.
Junyang Chen, Boya Liu, Xinlei Yao, Xiaoming Yang, Jiacheng Sun, Jia Yi, Fei Xue, Jitai Zhang, Yuntian Shen, Bingqian Chen, Hualin Sun   +10 more
wiley   +1 more source

Discovery of DS68702229 as a Potent, Orally Available NAMPT (Nicotinamide Phosphoribosyltransferase) Activator

, 2021
Mayuko Akiu, Takashi Tsuji, Kouki Iida, Yoshitaka Sogawa, Koji Terayama, Mika Yokoyama, Jun Tanaka, Daigo Asano, Tomohiro Honda, Ken Sakurai, Anthony B. Pinkerton, Tsuyoshi Nakamura   +11 more
openalex   +2 more sources

Effect of alternating nicotinamide phosphoribosyltransferase expression levels on mitophagy and pathological symptoms in Alzheimer’s disease mouse models [PDF]

, 2023
Na Zhao, Bo Xu, Jie Xia, Jing Wang, Xianliang Zhang, Qingwei Yan   +5 more
openalex   +1 more source