Results 81 to 90 of about 57,446 (263)

The Role of Nicotinamide Phosphoribosyltransferase in Cerebral Ischemia [PDF]

Current Topics in Medicinal Chemistry, 2015
As recombinant tissue plasminogen activator is the only drug approved for the clinical treatment of acute ischemic stroke, there is an urgent unmet need for novel stroke treatments. Endogenous defense mechanisms against stroke may hold the key to new therapies for stroke.
Xinzhi, Chen, Shangfeng, Zhao, Yang, Song, Yejie, Shi, Rehana K, Leak, Guodong, Cao   +5 more
openaire   +2 more sources

Globale Expressionsprofile Pneumokokken-infizierter Bronchialepithelzellen - Einfluss der miRNA-3135b und des Nicotinamidstoffwechselweges auf die bakterielle Replikation [PDF]

, 2018
Streptococcus pneumoniae (S. pneumoniae), auch als Pneumococcus bezeichnet, ist ein grampositives Bakterium, welches gewöhnlich als Kommensale asymptomatisch den humanen Nasopharynx besiedelt, jedoch auch schwere Erkrankungen bis hin zur Sepsis oder ...
Wesener, André
core   +1 more source

Extension of Human Cell Lifespan by Nicotinamide Phosphoribosyltransferase [PDF]

Journal of Biological Chemistry, 2007
Extending the productive lifespan of human cells could have major implications for diseases of aging, such as atherosclerosis. We identified a relationship between aging of human vascular smooth muscle cells (SMCs) and nicotinamide phosphoribosyltransferase (Nampt/PBEF/Visfatin), the rate-limiting enzyme for NAD+ salvage from nicotinamide.
Eric, van der Veer, Cynthia, Ho, Caroline, O'Neil, Nicole, Barbosa, Robert, Scott, Sean P, Cregan, J Geoffrey, Pickering   +6 more
openaire   +2 more sources

Identification of Melatonin-Regulated Genes in the Ovine Pituitary Pars Tuberalis, a Target Site for Seasonal Hormone Control [PDF]

, 2008
The pars tuberalis (PT) of the pituitary gland expresses a high density of melatonin (MEL) receptors and is believed to regulate seasonal physiology by decoding changes in nocturnal melatonin secretion.
Alison Downing, Ando, Andrew S. I. Loudon, Ashburner, Bae, Barrett, Bartness, Bechtold, Benoit Malpaux, Bockers, Bockers, Bockmann, Brahimi-Horn, Camon, Carr, Chemineau, Chen, Curlewis, Daphne Mouzaki, Dardente, Dave W. Burt, David Waddington, Draghici, Dupre, Fukuhara, Gerald A. Lincoln, Ghorbel, Graham, Grossmann, Hanon, Hazlerigg, Hazlerigg, Hazlerigg, Hogenesch, Hu, Hu, Johnston, Johnston, Johnston, Julian R. E. Davis, Kel, Kijas, Klosen, Ko, Lamolet, Lee, Lincoln, Lincoln, Lincoln, Lincoln, Malpaux, Merks, Messager, Michan, Morgan, Morgan, Mutoh, Nakao, Naya, Naya, Nilaweera, Oki, Poulin, Reick, Revollo, Richard Talbot, Roepke, Rutter, Samal, Sandrine M. Dupré, Schroeder, Segawa, Stehle, Stirland, Storey, Su, Tobler, Tournier, Wagner, Westfall, Williams, Wittkowski, Yang, Yokoyama   +83 more
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The Cytokine Nicotinamide Phosphoribosyltransferase (eNAMPT

Cells, 2020
(1) Background: Extracellular nicotinamide phosphoribosyltrasferase (eNAMPT) is released by various cell types with pro-tumoral and pro-inflammatory properties. In cancer, eNAMPT regulates tumor growth through the activation of intracellular pathways, suggesting that it acts through a putative receptor, although its nature is still elusive. It has been
Torretta, Colombo, Travelli, Boumya, Lim, Genazzani, Grolla   +6 more
openaire   +1 more source

The function of nicotinamide phosphoribosyltransferase in the heart [PDF]

DNA Repair, 2014
In addition to its roles as a coenzyme and an electron transfer molecule, nicotinamide adenine dinucleotide (NAD+) has emerged as a substrate of sirtuins, a family of enzymes that control aging and metabolism. Nicotinamide phosphoribosyltransferase (Nampt), a rate-limiting enzyme in the NAD+ salvage pathway, plays an important role in controlling the ...
Chiao-Po, Hsu, Takanobu, Yamamoto, Shinichi, Oka, Junichi, Sadoshima   +3 more
openaire   +2 more sources

The Efficacy of Risk Factor Modification Compared to NAD+ Repletion in Diastolic Heart Failure

JACC: Basic to Translational Science
Summary: Heart failure (HF) with left ventricular diastolic dysfunction is a growing global concern. This study evaluated myocardial oxidized nicotinamide adenine dinucleotide (NAD+) levels in human systolic and diastolic HF and in a murine model of HF ...
Yen Chin Koay, PhD, Ren Ping Liu, BS, Bailey McIntosh, BS, Niv Vigder, BS, Serlin Lauren, BS, Angela Yu Bai, BS, Saki Tomita, BS, Desmond Li, PhD, Dylan Harney, PhD, Benjamin Hunter, PhD, Yunwei Zhang, PhD, Jean Yang, PhD, Paul Bannon, MD, PhD, Ashleigh Philp, PhD, Andrew Philp, PhD, David M. Kaye, MD, PhD, Mark Larance, PhD, Sean Lal, MD, PhD, John F. O’Sullivan, MD, PhD   +18 more
doaj   +1 more source

Maintenance of NAD+ Homeostasis in Skeletal Muscle during Aging and Exercise

Cells, 2022
Nicotinamide adenine dinucleotide (NAD) is a versatile chemical compound serving as a coenzyme in metabolic pathways and as a substrate to support the enzymatic functions of sirtuins (SIRTs), poly (ADP-ribose) polymerase-1 (PARP-1), and cyclic ADP ribose
Li Li Ji, Dongwook Yeo
doaj   +1 more source

Perinatal asphyxia: CNS development and deficits with delayed onset [PDF]

, 2014
Perinatal asphyxia constitutes a prototype of obstetric complications occurring when pulmonary oxygenation is delayed or interrupted. The primary insult relates to the duration of the period lacking oxygenation, leading to death if not re-established ...
Bustamante, D, Esmar, D, ESPINA MARCHANT, P, GEBICKE HAERTER, Pj, GUTIERREZ HERNANDEZ, M, HERRERA MARSCHITZ, M, Morales, P, Munoz, V, NEIRA PENA, T, Perez, R, Rivera, B, ROJAS MANCILLA, E, Simola, Nicola   +12 more
core   +1 more source

Emerging therapeutic roles for NAD+ metabolism in mitochondrial and age-related disorders [PDF]

, 2016
Nicotinamide adenine dinucleotide (NAD(+)) is a central metabolic cofactor in eukaryotic cells that plays a critical role in regulating cellular metabolism and energy homeostasis. NAD(+) in its reduced form (i.e.
Sarika Srivastava
core   +1 more source