Results 21 to 30 of about 184,827 (247)

Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens

Frontiers in Pharmacology, 2023
With the growing number of individuals regularly using e-cigarettes, it has become increasingly important to understand the psychobiological effects of nicotine salts.
Xiaonan Li, Lehua Lu, Ying He, Hui Zhang, Yihui Zhang, Huaquan Sheng, Ming Chen, Ming Chen, Jiexiong Ru, Yihan Gao   +9 more
doaj   +1 more source

Personalized dosing of nicotine replacement therapy versus standard dosing for the treatment of individuals with tobacco dependence: study protocol for a randomized placebo-controlled trial

Trials, 2020
Background Medications for smoking cessation are currently only effective in helping a minority of smokers quit. Drug development is slow and expensive; as such, there is much interest in optimizing the effectiveness of existing treatments and ...
Laurie Zawertailo, Christian S. Hendershot, Rachel F. Tyndale, Bernard Le Foll, Andriy V. Samokhvalov, Kevin E. Thorpe, Andrew Pipe, Robert D. Reid, Peter Selby   +8 more
doaj   +1 more source

Sociodemographic differences in patterns of nicotine and cannabis vaping among US adults

Preventive Medicine Reports, 2022
Nicotine and cannabis vaping has increased over the past several years. While patterns of cigarette and cannabis co-use are well-documented, less is known about the intersection between nicotine and cannabis vaping, especially among adults.
Delvon T. Mattingly, Akash Patel, Jana L. Hirschtick, Nancy L. Fleischer   +3 more
doaj   +1 more source

Differences in nicotine metabolism of two Nicotiana attenuata herbivores render them differentially susceptible to a common native predator. [PDF]

PLoS ONE, 2014
Nicotiana attenuata is attacked by larvae of both specialist (Manduca sexta) and generalist (Spodoptera exigua) lepidopteran herbivores in its native habitat. Nicotine is one of N. attenuata's important defenses. M.
Pavan Kumar, Preeti Rathi, Matthias Schöttner, Ian T Baldwin, Sagar Pandit   +4 more
doaj   +1 more source

Identification of nicotine-seeking and avoiding larval zebrafish using a new three-choice behavioral assay

Frontiers in Molecular Neuroscience, 2023
IntroductionNicotine dependence is one of the main causes of preventable diseases in the United States. Nicotine-seeking and avoidance behavioral assays in larval zebrafish could be used for identifying potential new pharmacotherapeutics in an early ...
Henning Schneider, Anna Pearson, Drew Harris, Sabrina Krause, Andrew Tucker, Kaitlyn Gardner, Kuzivakwashe Chinyanya   +6 more
doaj   +1 more source

Comparative evaluation of the efficacy of nicotine chewing gum and nicotine patches as nicotine replacement therapy using salivary cotinine levels as a biochemical validation measure

Indian Journal of Psychiatry, 2023
Background: Nicotine replacement therapy (NRT) and habit cessation counseling are considered the mainstay treatment for high nicotine dependence smokers. However, adherence to NRT is very poor.
T Sivasankari, Avudaiappan Sankaran, Senthil Murugappan, Veni Subramanyam, Balanehru Subramanian, RC Jagat Reddy, S Vandana   +6 more
doaj   +1 more source

An integrated digital/clinical approach to smoking cessation in lung cancer screening: study protocol for a randomized controlled trial

Trials, 2017
Background Delivering effective tobacco dependence treatment that is feasible within lung cancer screening (LCS) programs is crucial for realizing the health benefits and cost savings of screening.
Amanda L. Graham, Michael V. Burke, Megan A. Jacobs, Sarah Cha, Ivana T. Croghan, Darrell R. Schroeder, James P. Moriarty, Bijan J. Borah, Donna F. Rasmussen, M. Jody Brookover, Dale B. Suesse, David E. Midthun, J. Taylor Hays   +12 more
doaj   +1 more source

Does it come from tobacco? Young adults’ interpretations of the term “tobacco-free nicotine” in a cross-sectional national survey sample

PLoS ONE, 2022
Background “Tobacco-free” nicotine (TFN) e-cigarettes and nicotine pouches containing synthetic nicotine are increasingly available. The term TFN may lead to reduced risk perceptions and increased use intentions relative to tobacco-derived nicotine ...
Meghan E. Morean, Krysten W. Bold, Danielle R. Davis, Grace Kong, Suchitra Krishnan-Sarin, Deepa R. Camenga   +5 more
doaj   +2 more sources

Dissolution Testing of Nicotine Release from OTDN Pouches: Product Characterization and Product-to-Product Comparison

Separations, 2021
In recent years, oral tobacco-derived nicotine (OTDN) pouches have emerged as a new oral tobacco product category. They are available in a variety of flavors and do not contain cut or ground tobacco leaf.
Fadi Aldeek, Nicholas McCutcheon, Cameron Smith, John H. Miller, Timothy L. Danielson   +4 more
doaj   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source