Results 1 to 10 of about 329,742 (333)

Enzymatic approaches to nicotinic acid synthesis: recent advances and future prospects [PDF]

Frontiers in Bioengineering and Biotechnology
Biocatalyst-mediated reactions have led to revolutionary transformations in the organic synthesis of pharmaceuticals, drugs, and other chemicals.
Rahul Vikram Singh, Vipin Chandra Kalia, Krishika Sambyal, Bakul Singh, Anurag Kumar, Jung-Kul Lee   +5 more
doaj   +2 more sources

Unique nicotinic responses are present in distinct subtypes of mouse medial prefrontal layer V pyramidal neurons [PDF]

Scientific Reports
The neurotransmitter acetylcholine supports goal-directed cognitive functions via activation of its nicotinic and muscarinic classes of receptors within the prefrontal cortex.
Ashutosh V. Patel, Anthony Nguyen, Ashley A. Geremia, Donia Zeng, Pietro Paletta, Elena Choleris, Craig D. C. Bailey   +6 more
doaj   +2 more sources

Homomeric and Heteromeric α7 Nicotinic Acetylcholine Receptors in Health and Some Central Nervous System Diseases

Membranes, 2021
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels involved in the modulation of essential brain functions such as memory, learning, and attention.
Virginia Borroni, Francisco J. Barrantes
doaj   +1 more source

Characterizing the Access of Cholinergic Antagonists to Efferent Synapses in the Inner Ear

Frontiers in Neuroscience, 2021
Stimulation of cholinergic efferent neurons innervating the inner ear has profound, well-characterized effects on vestibular and auditory physiology, after activating distinct ACh receptors (AChRs) on afferents and hair cells in peripheral endorgans ...
Choongheon Lee, Anjali K. Sinha, Kenneth Henry, Kenneth Henry, Anqi W. Walbaum, Peter A. Crooks, Joseph C. Holt, Joseph C. Holt, Joseph C. Holt   +8 more
doaj   +1 more source

Loss of α-9 Nicotinic Acetylcholine Receptor Subunit Predominantly Results in Impaired Postural Stability Rather Than Gaze Stability

Frontiers in Cellular Neuroscience, 2022
The functional role of the mammalian efferent vestibular system (EVS) is not fully understood. One proposal is that the mammalian EVS plays a role in the long-term calibration of central vestibular pathways, for example during development.
Hui Ho Vanessa Chang, Barbara J. Morley, Kathleen E. Cullen, Kathleen E. Cullen, Kathleen E. Cullen, Kathleen E. Cullen   +5 more
doaj   +1 more source

Cholinergic Signaling, Neural Excitability, and Epilepsy

Molecules, 2021
Epilepsy is a common brain disorder characterized by recurrent epileptic seizures with neuronal hyperexcitability. Apart from the classical imbalance between excitatory glutamatergic transmission and inhibitory γ-aminobutyric acidergic transmission ...
Yu Wang, Bei Tan, Yi Wang, Zhong Chen
doaj   +1 more source

Acetylcholine regulation of GnRH neuronal activity: A circuit in the medial septum

Frontiers in Endocrinology, 2023
In vertebrates, gonadotropin-releasing hormone (GnRH)-secreting neurons control fertility by regulating gonadotrophs in the anterior pituitary. While it is known that acetylcholine (ACh) influences GnRH secretion, whether the effect is direct or indirect,
David M. Shostak, Stephanie Constantin, Jill Flannery, Susan Wray   +3 more
doaj   +1 more source

Neuronal Nicotinic Receptors as New Targets for Amphetamine-Induced Oxidative Damage and Neurotoxicity

Pharmaceuticals, 2011
Amphetamine derivatives such as methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) are widely abused drugs in a recreational context.
Elena Escubedo, Sara Garcia-Ratés, Jordi Camarasa, David Pubill   +3 more
doaj   +1 more source

Differential Contribution of Subunit Interfaces to α 9 α 10 Nicotinic Acetylcholine Receptor Function [PDF]

, 2017
Nicotinic acetylcholine receptors can be assembled from either homomeric or heteromeric pentameric subunit combinations. At the interface of the extracellular domains of adjacent subunits lies the acetylcholine binding site, composed of a principal ...
Boffi, Juan Carlos, Bouzat, Cecilia Beatriz, Collins, Toby, Corradi, Jeremias, Craig, Patricio Oliver, Elgoyhen, Ana Belen, Gill Thind, JasKiran K., Lipovsek, Maria Marcela, Marcovich, Irina, Millar, Neil S., Moglie, Marcelo Javier, Plazas, Paola Viviana   +11 more
core   +3 more sources

Evolution in Neuromodulation—The Differential Roles of Acetylcholine in Higher Order Association vs. Primary Visual Cortices

Frontiers in Neural Circuits, 2018
This review contrasts the neuromodulatory influences of acetylcholine (ACh) on the relatively conserved primary visual cortex (V1), compared to the newly evolved dorsolateral prefrontal association cortex (dlPFC).
Veronica C. Galvin, Amy F. T. Arnsten, Min Wang   +2 more
doaj   +1 more source