Results 31 to 40 of about 331,963 (334)

Regions of beta 2 and beta 4 responsible for differences between the steady state dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors [PDF]

, 1995
We constructed chimeras of the rat beta 2 and beta 4 neuronal nicotinic subunits to locate the regions that contribute to differences between the acetylcholine (ACh) dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 receptors ...
Cohen, B. N., Davidson, N., Figl, A., Labarca, C., Lester, H. A., Quick, M. W.   +5 more
core   +2 more sources

Reduced Nicotine Content Cigarettes and Nicotine Patch [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2013
Abstract Background: Reduced nicotine content (RNC) cigarettes have led to smoking fewer cigarettes, withdrawal relief, and facilitation of cessation. The aim of this study is to examine the effects RNC cigarettes with and without nicotine patch and patch alone on smoking behavior, toxicant exposure, withdrawal discomfort, and as an ...
Dorothy K, Hatsukami, Louise A, Hertsgaard, Rachel I, Vogel, Joni A, Jensen, Sharon E, Murphy, Stephen S, Hecht, Steven G, Carmella, Mustafa, al'Absi, Anne M, Joseph, Sharon S, Allen   +9 more
openaire   +2 more sources

The antisaccade task as an index of sustained goal activation in working memory: modulation by nicotine [PDF]

, 2006
The antisaccade task provides a laboratory analogue of situations in which execution of the correct behavioural response requires the suppression of a more prepotent or habitual response.
A Nordberg, AL Larrison, AL Larrison-Faucher, B Fischer, B Reuter, C Massen, C Pierrot-Deseilligny, C Vidal, CM Martin-Ruiz, CS Myers, D Paterson, DM Warburton, DP Munoz, DV Poltavski, E Stuyven, EA Witte, ED Levin, ED Levin, ED Levin, G Mancuso, HM Arnold, J Foulds, J Leon de, J Powell, Jennifer M. Rusted, JG Harris, JH Bettany, JJ Buccafusco, JJ Buccafusco, JM Findlay, JP Mitchell, KA Perkins, KO Fagerström, L Depatie, M Ernst, M Reuben, ME Calkins, N Rycroft, N Unsworth, Nicola Rycroft, PBS Clarke, PE Hallett, R Dar, R Godijn, RJ Leigh, RJ Roberts, RJ West, RM Eenshuistra, S Leonard, S Nieuwenhuis, SA Khan, Samuel B. Hutton, SB Hutton, SB Hutton, SB Hutton, T Bates, T Edginton, U Ettinger, U Ettinger, V Casa Della, V Kumari, V Kumari, WA Corrigall, WS Griesar, YBWEM Roos   +64 more
core   +1 more source

Habenular α5* nicotinic receptor signaling controls nicotine intake

Nature, 2011
Genetic variation in CHRNA5, the gene encoding the α5 nicotinic acetylcholine receptor subunit, increases vulnerability to tobacco addiction and lung cancer, but the underlying mechanisms are unknown.
C. Fowler, Qun Lu, Paul M Johnson, M. Marks, P. Kenny   +4 more
semanticscholar   +1 more source

Temporal Trends in and Associations With Nonsteroidal Anti‐inflammatory Drug Prescription in Adult and Pediatric Patients With Inflammatory Bowel Disease

Arthritis Care &Research, EarlyView.
Objective Recent inflammatory bowel disease (IBD) treatment guidelines have recommended against nonsteroidal anti‐inflammatory drug (NSAID) use despite prevalent musculoskeletal symptoms and opioid overuse in this population. Given the discordance between changing national guidelines and potential clinical utility, we sought to assess national temporal
Adam S. Mayer, Rui Xiao, Andrew Grossman, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +5 more
wiley   +1 more source

Nicotine-Induced Effects on Nicotinic Acetylcholine Receptors (nAChRs), Ca2+ and Brain-Derived Neurotrophic Factor (BDNF) in STC-1 Cells [PDF]

, 2016
In addition to the T2R bitter taste receptors, neuronal nicotinic acetylcholine receptors (nAChRs) have recently been shown to be involved in the bitter taste transduction of nicotine, acetylcholine and ethanol.
Alkahtan, Reem M., Grider, John R., Lyall, Vijay, Mahavadi, Sunila, Mummalaneni, Shobha K., Murthy, Karnam S., Qian, Jie   +6 more
core   +3 more sources

Biomaterials‐Based Hydrogel with Superior Bio‐Mimetic Ionic Conductivity and Tissue‐Matching Softness for Bioelectronics

Advanced Functional Materials, EarlyView.
By mimicking the ion‐accelerating effect of ion channel receptors in neuron membranes, a biomaterials‐based ionic hydrogel (BIH) is developed, which offers a high ionic conductivity of 7.04 S m−1, outperforming conventional chitosan, cellulose, agarose, starch, and gelatin based ionic hydrogels.
Baojin Chen, Renjie Yu, Jiaqi Wang, Yunxiang Feng, Yujie Zhang, Yanchao Mao, Chongxin Shan, Xudong Wang   +7 more
wiley   +1 more source

Chronic Nicotine Selectively Enhances α4β2* Nicotinic Acetylcholine Receptors in the Nigrostriatal Dopamine Pathway [PDF]

, 2009
These electrophysiological experiments, in slices and intact animals, study the effects of in vivo chronic exposure to nicotine on functional α4β2* nAChRs in the nigrostriatal dopaminergic (DA) pathway.
Cai, Haijiang, Lester, Henry A., McIntosh, J. Michael, McKinney, Sheri, Nashmi, Raad, Xiao, Cheng   +5 more
core  

It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]

, 2016
The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
core   +2 more sources

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source