Results 131 to 140 of about 145,182 (364)

Prenatal Nicotine Exposure as a Teratogen in Neurological Pathways [PDF]

open access: yes, 2016
Attention-deficit/hyperactivity disorder (ADHD) is the most heritable and commonly diagnosed childhood psychiatric disorder with 4% of all children being diagnosed with this disorder.
Grover, Monica
core   +1 more source

Neural mechanisms and clinical features of anti‐influenza drug‐related psychiatric adverse events

open access: yesVIEW, EarlyView.
Anti–influenza drugs, while essential, have been increasingly associated with psychiatric adverse events (pAEs). Our study systematically investigated these pAEs by utilizing large pharmacovigilance databases and animal models, thereby revealing key clinical features and underlying neural mechanisms.
Anqi Lin   +9 more
wiley   +1 more source

Acetylcholine induces stem cell properties of gastric cancer cells of diffuse type

open access: yesTumor Biology, 2018
Gastric cancer is the third leading cause of cancer-related death worldwide, but the mechanisms of gastric carcinogenesis are not completely understood.
Phu Hung Nguyen   +8 more
doaj   +1 more source

Frequent occurrence of nicotinic acetylcholine receptors in GABAergic neurons of the chick visual system

open access: yesBrazilian Journal of Medical and Biological Research, 2001
Double-labeling immunohistochemical methods were used to investigate the occurrence of the alpha8 and alpha5 nicotinic receptor subunits in presumptive GABAergic neurons of the chick nervous system.
A.S. Torrão, L.R.G. Britto
doaj   +1 more source

Sequencing of rabies binding region on nicotinic acteylcholine receptor alpha subunits in four host species [PDF]

open access: yes, 2013
• Rabies virus is known to bind to nicotinic acetylcholine receptors (nAchR) • The virus is known to bind to alpha 1 subunits nAchR • The virus binding region has been characterized in alpha 1 subunits of these receptors • Little research has been ...
Barnard, Karen
core  

The NMDA Receptor Antagonist Memantine Modulates Aging and Stress Resilience

open access: yesAging Cell, EarlyView.
Memantine, an NMDA receptor antagonist, extends lifespan and enhances stress resilience in C. elegans through caloric restriction–like metabolic adaptations, including reduced oxidative stress and increased fatty acid β‐oxidation, revealing a conserved mechanism linking glutamatergic signaling to healthy aging.
Vaida Juozaityte   +8 more
wiley   +1 more source

Inhibitory effects of pine nodule extract and its component, SJ-2, on acetylcholine-induced catecholamine secretion and synthesis in bovine adrenal medullary cells

open access: yesJournal of Pharmacological Sciences, 2017
Extract of pine nodules (matsufushi) formed by bark proliferation on the surface of trees of Pinus tabulaeformis or Pinus massoniana has been used as an analgesic for joint pain, rheumatism, neuralgia, dysmenorrhea and other complaints in Chinese ...
Xiaojia Li   +11 more
doaj   +1 more source

High‐ and low‐dose topiramate for the treatment of persons with alcohol use disorder who smoke cigarettes: A randomized control trial

open access: yesAlcohol, Clinical and Experimental Research, EarlyView.
Participants (n = 236) from three sites were randomly assigned to either placebo, low‐dose topiramate (up to 125 mg/day), or high‐dose topiramate (up to 250 mg/day) for up to 18 weeks. Exploratory analyses indicated that participants treated with the high dose had lower mean percentage of heavy drinking days and drinks per day than those taking the low
Jason D. Robinson   +6 more
wiley   +1 more source

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

open access: yesActa Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian   +3 more
wiley   +1 more source

The role of acetylcholine and its receptors in tumor immune regulation: mechanisms and potential therapeutic targets

open access: yesMolecular Cancer
Acetylcholine (ACh) is an essential neurotransmitter that has recently gained attention for its multifunctional role in tumor immune regulation.
Chunyu Zhang   +4 more
doaj   +1 more source

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