Results 161 to 170 of about 79,918 (320)

Single‐Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma

Advanced Science, Volume 13, Issue 5, 27 January 2026.
KYNA regulates the tumor immune microenvironment in glioblastoma. KYNA reprograms the balance between T cell exhaustion and activation to suppress glioblastoma progression through inhibiting exhaustion‐associated markers (such as PD‐1, LAG3, and TOX) and enhancing immune activation and cytotoxicity markers including granzymes GZMA and GZMB.
Di Chen, Liming Sun, Jiajun Chen, Zi Ye, Xuqiang Zhu, Hongjiang Li, Lixin Wu, Guohua Zhao, Qinghao Zhang, Guangyi Jiang, Yuchen Ji, Yake Xue, Hongwei Li, Ruokun Chen, Hongwei Zheng, Rong Zeng, Dongming Yan, Yong Zhang, Xueyuan Li, Jing Yan   +19 more
wiley   +1 more source

Synthesis of α3β4 Nicotinic Acetylcholine Receptor Modulators Derived from Aristoquinoline that Reduce Reinstatement of Cocaine-Seeking Behavior [PDF]

, 2023
Lisa E. Rusali, Ana M. Lopez-Hernandez, Kyle M. Kremiller, Gauri Kulkarni, Abhishek Gour, Carolyn J. Straub, Malaika D. Argade, Christian J. Peters, Abhisheak Sharma, Lawrence Toll, Andrea Cippitelli, Andrew P. Riley   +11 more
openalex   +1 more source

Smoking‐Induced STC2+ Tumor Cells Drive Tumor‐Vascular Crosstalk in Laryngeal Squamous Cell Carcinoma via Spatial and Single‐Cell Transcriptomics

Advanced Science, Volume 13, Issue 5, 27 January 2026.
This study identifies a smoking‐induced mechanism in LSCC whereby nicotine activates the CHRNA5–JAK2/STAT3 axis to drive STC2 transcription. STC2 upregulates TGFBI, which interacts with endothelial ITGA5 to regulate vascular permeability and promote metastasis.
Yujie Shen, Lianchong Gao, Qiang Huang, Liang Zhou, Chengzhi Xu, Chunping Wu   +5 more
wiley   +1 more source

A Whiff of Garlic, a Turn of Fate: Recognizing Organophosphorus Poisoning Amid Diagnostic Uncertainty: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT OP compounds, commonly used as pesticides, are readily available over the counter and frequently implicated in intentional poisoning. We report a case of a 43‐year‐old male with OP poisoning initially misdiagnosed as alcohol intoxication. He was intubated in the emergency department on arrival due to a low Glasgow Coma Scale (GCS) of 6/15 and ...
Sujan Tamang, Bishwo Ram Amatya, Sulav Neupane, Sunischit Chandra Neupane, Chiranjivi Panta, Anusmriti Pal, Dipesh Shrestha   +6 more
wiley   +1 more source

Nicotinic Acetylcholine Receptor Subunit Alpha-5 Promotes Radioresistance via Recruiting E2F Activity in Oral Squamous Cell Carcinoma [PDF]

, 2019
Che-Hsuan Lin, Hsun‐Hua Lee, Chia-Hao Kuei, Hui-Yu Lin, Long‐Sheng Lu, Fei‐Peng Lee, Jungshan Chang, Jia‐Yi Wang, Kai‐Cheng Hsu, Yuan‐Feng Lin   +9 more
openalex   +1 more source

Altered Functional Specialization and Interhemispheric Coordination in Rhegmatogenous Retinal Detachment: Associations With Gene Expression, Neurotransmitter Receptor Distribution, and SVM–SHAP Classification

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Autonomy Index (AI) and Connective Flexibility of Homotopic voxels (CFH) were derived from resting‐state fMRI data following standard preprocessing. These functional metrics were computed based on the AAL90 atlas to characterize intrinsic activity and interhemispheric coordination patterns in RRD patients.
Yu Ji, Yuan‐Yuan Wang, Xiao‐Rong Wu
wiley   +1 more source

In vivo knockdown of nicotinic acetylcholine receptor α1 diminishes aortic atherosclerosis

, 2010
Guoqiang Zhang, Amanda L. Marshall, Alison Thomas, Kelly Kernan, Yanyuan Su, Renee Leboeuf, Xiu Rong Dong, Bie Nga Tchao   +7 more
openalex   +2 more sources

Central regulation mechanisms for brain nicotinic acetylcholine receptor-mediated activation of the sympatho-adrenomedullary outflow

, 2020
Takahiro Shimizu, Shogo Shimizu, Youichirou Higashi, Motoaki Saito   +3 more
openalex   +2 more sources

Cloning and Functional Characterisation of Two Novel Nicotinic Acetylcholine Receptor α Subunits from the Insect Pest Myzus persicae [PDF]

, 1998
Frédéric Sgard, Scott P. Fraser, M J Katkowska, M.B.A. Djamgoz, S. J. Dunbar, John D. Windass   +5 more
openalex   +1 more source

Vanillin Modulates the Sedative Effect of Diazepam, Possibly Through GABAergic Interaction Pathways in Thiopental Sodium‐Induced Sleeping Mice

Food Safety and Health, Volume 4, Issue 1, Page 220-232, January 2026.
Vanillin showed moderate sedative and modulatory synergistic activities on diazepam in thiopental sodium‐induced sleeping mice. These effects are implicated with GABAergic intervention. ABSTRACT Insomnia is a common sleep disorder affecting approximately 10% of adults.
Salehin Sheikh, Md. Shimul Bhuia, Raihan Chowdhury, Md. Sakib Al Hasan, Most. Israt Jahan Oni, Imam Hossen Rakib, Mir Imran Alim, Jakia Sultana, Muhammad Torequl Islam   +8 more
wiley   +1 more source