The quest for the best target genes for RNAi‐mediated pest control
Insect Molecular Biology, EarlyView.A major challenge for RNAi mediated pest control is the identification of the most effective RNAi target genes from the pool of ~37% of all genes that are essential. Effective RNAi target genes are predominantly highly conserved genes serving basic cellular functions such as protein degradation.
Doga Cedden, Gregor Bucher
wiley +1 more source
Three conductance classes of nicotinic acetylcholine receptors are expressed in developing amphibian skeletal muscle [PDF]
, 1989 JL Owens, R Kullberg
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Cholinergic Modulation of Locomotion and Striatal Dopamine Release Is Mediated by α6α4* Nicotinic Acetylcholine Receptors [PDF]
, 2010 Dopamine (DA) release in striatum is governed by firing rates of midbrain DA neurons, striatal cholinergic tone, and nicotinic ACh receptors (nAChRs) on DA presynaptic terminals.
Drenan, Ryan M. +8 more
core
Enteric neuropathy and the vagus nerve: Therapeutic implications
Neurogastroenterology &Motility, EarlyView.Abstract Enteric neuropathies are characterized by abnormalities of gut innervation, which includes the enteric nervous system, inducing severe gut dysmotility among other dysfunctions. Most of the gastrointestinal tract is innervated by the vagus nerve, the efferent branches of which have close interconnections with the enteric nervous system and ...
Bruno Bonaz
wiley +1 more source
Metabolic stability and antigenic modulation of nicotinic acetylcholine receptors on bovine adrenal chromaffin cells. [PDF]
, 1988 Linda S. Higgins, D K Berg
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Decoding Gastric Reflexes: The Role of Mechanosensitive Enteric Neurons in Stomach Motility
Neurogastroenterology &Motility, EarlyView.ABSTRACT This review focuses on mechanosensitive enteric neurons (MEN) in the guinea pig stomach and their roles in gastric motor reflex pathways. The guinea pig model is advantageous for studying gastric physiology, as its stomach structure and function closely resemble those of humans. Gastric motility involves distinct functional regions: the fundus
Gemma Mazzuoli‐Weber +2 more
wiley +1 more source
Contemporary Concise Review 2024: Chronic Obstructive Pulmonary Disease
Respirology, EarlyView.SUMMARY OF KEY POINTS Non‐smoking COPD is common in LMICs, especially in women. Biomass fuel and air pollution are major risk factors with distinct pathophysiology. The ‘eosinophilic’ endotype in COPD is biologically distinct from asthma. PRISm, FEV1/FVC Z‐scores, and quantitative CT improve early COPD detection.
Sarita Thawanaphong, Parameswaran Nair
wiley +1 more source
Autoimmune T lymphocytes in myasthenia gravis. Determination of target epitopes using T lines and recombinant products of the mouse nicotinic acetylcholine receptor gene. [PDF]
, 1989 Arthur Melms +6 more
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Respirology, EarlyView.ABSTRACT Electronic cigarette (EC) use, especially among younger members of society, has grown to concerning levels in many countries, including Australia and New Zealand. Uptake in the general population, driven by technological and pharmacological innovations, and accelerated by aggressive tobacco/vaping industry marketing, has outpaced medical ...
Henry Marshall +13 more
wiley +1 more source
Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.Tetra‐ortho‐Azobenzenes (TOABs) in broad daylight: in recent years, TOAB photoswitches became indispensable tools for all‐visible‐light manipulation of chemistry, biology and materials. This review explores their unique photochemical properties, design and synthetic approaches, offering support in choosing a TOAB for a given application.
Francesca Cardano +2 more
wiley +2 more sources