Arachidonic Acid as a Possible Negative Feedback Inhibitor of Nicotinic Acetylcholine Receptors on Neurons [PDF]
, 1995 Neuronal acetylcholine receptors, being highly permeable to calcium, are likely to regulate calcium-dependent events in neurons. Arachidonic acid is a membrane-permeant second messenger that can be released from membrane phospholipids by phospholipases ...
Berg, Darwin K. +3 more
core +2 more sources
Nicotinic acetylcholine receptors and cancer
Biomedical Reports, 2016 Nicotine, the primary addictive constituent of cigarettes, is believed to contribute to cancer promotion and progression through the activation of nicotinic acetylcholine receptors (nAChRs), which are membrane ligand-gated cation channels. nAChRs activation can be triggered by the neurotransmitter Ach, or certain other biological compounds, such as ...
Xianguang Meng +2 more
openaire +4 more sources
Anti-inflammation of spirocyclopiperazinium salt compound LXM-10 targeting α7 nAChR and M4 mAChR and inhibiting JAK2/STAT3 pathway in rats. [PDF]
PLoS ONE, 2013 The present study aims to investigate the therapeutic effects of LXM-10 by intragastric administration in both acute and chronic inflammatory models, and to explore the underlying molecular mechanisms.
Weiwei Zhang +5 more
doaj +1 more source
Taxonomy of Chemical Bondings: Opportunities and Challenges
Angewandte Chemie, EarlyView.The recent focus on supramolecular and nanosized systems produced a major increase in the types of observed noncovalent interactions and in the diversity of terms used to designate them. A hierarchical categorization (taxonomy) of terms used to designate electrophile···nucleophile interactions is proposed here.
Andrea Pizzi +5 more
wiley +2 more sources
Coordination of opposing sex-specific and core muscle groups regulates male tail posture during Caenorhabditis elegans male mating behavior [PDF]
, 2009 Background To survive and reproduce, animals must be able to modify their motor behavior in response to changes in the environment. We studied a complex behavior of Caenorhabditis elegans, male mating behavior, which provided a model for understanding ...
A Barrios +45 more
core +4 more sources
Diversity of vertebrate nicotinic acetylcholine receptors [PDF]
Neuropharmacology, 2009 Nicotinic acetylcholine receptors (nAChRs) are pentameric neurotransmitter receptors. They are members of the Cys-loop family of ligand-gated ion channels which also include ionotropic receptors for 5-hydroxytryptamine (5-HT), gamma-aminobutyric acid (GABA) and glycine.
Millar NS, Gotti C
openaire +4 more sources
Muscarinic and Nicotinic Contribution to Contrast Sensitivity of Macaque Area V1 Neurons
Frontiers in Neural Circuits, 2017 Acetylcholine is a neuromodulator that shapes information processing in different cortical and subcortical areas. Cell type and location specific cholinergic receptor distributions suggest that acetylcholine in macaque striate cortex should boost feed ...
Jose L. Herrero +2 more
doaj +1 more source
Molecular Brain, 2022 Nicotinic acetylcholine receptors are thought to be associated with a wide range of phenomena, such as movement, learning, memory, attention, and addiction. However, the causal relationship between nicotinic receptor activity and behavior remains unclear.
Shohei Kaneko +5 more
doaj +1 more source
Nicotine addiction : a review [PDF]
, 2013 Nicotine, the major psychoactive compound in tobacco, acts as a potent addictive drug in humans. The addictive nature of nicotine leads to more than 6 million deaths a year.
Di Giovanni, Giuseppe, Vella, Jacob
core +1 more source
The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia. [PDF]
PLoS ONE, 2016 The development of alpha7 nicotinic acetylcholine receptor agonists is considered a promising approach for the treatment of cognitive symptoms in schizophrenia patients. In the present studies we characterized the novel agent, (2R)-N-(6-(1H-imidazol-1-yl)
Linda J Bristow +22 more
doaj +1 more source