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Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails [PDF]
Marine Drugs, 2018 Marine cone snails are a large family of gastropods that have evolved highly potent venoms for predation and defense. The cone snail venom has exceptional molecular diversity in neuropharmacologically active compounds, targeting a range of receptors, ion
Nikita Abraham, Richard J. Lewis
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PLoS ONE, 2014 Phospholipases A2 represent the most abundant family of snake venom proteins. They manifest an array of biological activities, which is constantly expanding. We have recently shown that a protein bitanarin, isolated from the venom of the puff adder Bitis
Catherine A Vulfius +9 more
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Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview
Marine Drugs, 2014 Marine snails of the genus Conus are a large family of predatory gastropods with an unparalleled molecular diversity of pharmacologically active compounds in their venom.
Eline K. M. Lebbe +3 more
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Nicotinic acetylcholine receptors in neuropathic and inflammatory pain
FEBS Letters, 2017 Arik J. Hone, J. Michael McIntosh
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Impulsive Behavior and Nicotinic Acetylcholine Receptors
Journal of Pharmacological Sciences, 2012 Higher impulsivity is thought to be a risk factor for drug addiction, criminal involvement, and suicide. Excessive levels of impulsivity are often observed in several psychiatric disorders including attention-deficit/hyperactivity disorder and ...
Yu Ohmura +2 more
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Nicotinic acetylcholine receptors mediate lung cancer growth
Frontiers in Physiology, 2013 Ion channels modulate ion flux across cell membranes, activate signal transduction pathways, and influence cellular transport – vital biological functions that are inexorably linked to cellular processes that go awry during carcinogenesis.
Ma. Reina eImprogo +3 more
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Therapeutic Targeting of α7 Nicotinic Acetylcholine Receptors
Pharmacological Reviews, 2021 The α7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all the members of the cys-loop superfamily of ligand-gated ion channels.
R. Papke, N. Horenstein
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Erythrina mulungu alkaloids are potent inhibitors of neuronal nicotinic receptor currents in mammalian cells. [PDF]
PLoS ONE, 2013 Crude extracts and three isolated alkaloids from Erythrina mulungu plants have shown anxiolytic effects in different animal models. We investigated whether these alkaloids could affect nicotinic acetylcholine receptors and if they are selective for ...
Pedro Setti-Perdigão +5 more
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Pharmacological Research, 2023 Initiated by findings that Alzheimer’s disease is associated with a profound loss of cholinergic markers in human brain, decades of studies have examined the interactions between specific subtypes of nicotinic acetylcholine receptors and amyloid-β ...
Paul Whiteaker, Andrew A. George
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Signaling of nicotinic acetylcholine receptors in mononuclear phagocytes
Pharmacological Research, 2023 Nicotinic acetylcholine receptors are not only expressed by the nervous system and at the neuro-muscular junction but also by mononuclear phagocytes, which belong to the innate immune system.
Katrin Richter, Veronika Grau
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