Enteric neuropathy and the vagus nerve: Therapeutic implications
Neurogastroenterology &Motility, EarlyView.Abstract Enteric neuropathies are characterized by abnormalities of gut innervation, which includes the enteric nervous system, inducing severe gut dysmotility among other dysfunctions. Most of the gastrointestinal tract is innervated by the vagus nerve, the efferent branches of which have close interconnections with the enteric nervous system and ...
Bruno Bonaz
wiley +1 more source
Schizophrenia is a TH2 dominant autoimmune disease possibly against acetylcholine receptors of CNS [PDF]
, 2012 Schizophrenia is a very common psychiatric disorder. However, its etiology and pathogenesis is still unknown. Current theory saying that neurotransmitter imbalance such as serotonin or dopamine only provides limited effectiveness in schizophrenia ...
Wanchung(Wan-Jiung) Hu
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Is Adipose Tissue Inflammation the Culprit of Obesity‐Associated Comorbidities?
Obesity Reviews, EarlyView.ABSTRACT In individuals with obesity, the onset of chronic comorbidities coincides with the excessive accumulation of adipose tissue in various tissue beds. As obesity progresses, adipose tissue becomes increasingly dysfunctional causing chronic low‐grade inflammation.
Laurent Turner +3 more
wiley +1 more source
Weight Loss‐Associated Remodeling of Adipose Tissue Immunometabolism
Obesity Reviews, EarlyView.ABSTRACT Obesity is a multifactorial condition characterized by excessive adiposity and systemic chronic low‐grade inflammation. Recent literature reflects a growing appreciation for the complex interplay between metabolism and the immune system in the pathogenesis of obesity‐related health conditions.
Paulo José Basso +5 more
wiley +1 more source
Neural Regeneration Research, 2017 Neurodegenerative diseases, such as Alzheimer's, Parkinson's and Huntington's diseases, are all characterized by a component of innate immunity called neuroinflammation. Neuronal loss and neuroinflammation are two phenomena closely linked.
Laura Foucault-Fruchard, Daniel Antier
doaj +1 more source
Differential expression of nicotinic acetylcholine receptor genes in innervated and denervated chicken muscle. [PDF]
, 1987 Stephen J. Moss +4 more
openalex +1 more source
Neuroimmune pathophysiology of long COVID
Psychiatry and Clinical Neurosciences, EarlyView.Although COVID‐19 was originally considered a respiratory illness, it is now well established that SARS‐CoV‐2 infection can have far‐reaching impacts on the nervous system. Neurological symptoms such as chemosensory dysfunction are frequently observed during acute infection and approximately 10% of COVID‐19 cases will go on to develop new or persistent
Janna K. Moen +2 more
wiley +1 more source
Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia
Neurobiology of Disease, 2019 Trihexyphenidyl, a nonselective muscarinic receptor antagonist, is the small molecule drug of choice for the treatment of DYT1 dystonia, but it is poorly tolerated due to significant side effects.
Anthony M. Downs +4 more
doaj
Acute Administration of Desformylflustrabromine Relieves Chemically Induced Pain in CD-1 Mice
Molecules, 2019 Neuronal nicotinic acetylcholine receptors are cell membrane-bound ion channels that are widely distributed in the central nervous system. The α4β2 subtype of neuronal nicotinic acetylcholine receptor plays an important role in modulating the ...
Loni A. Weggel, Anshul A. Pandya
doaj +1 more source
Cholinergic Modulation of Locomotion and Striatal Dopamine Release Is Mediated by α6α4* Nicotinic Acetylcholine Receptors [PDF]
, 2010 Dopamine (DA) release in striatum is governed by firing rates of midbrain DA neurons, striatal cholinergic tone, and nicotinic ACh receptors (nAChRs) on DA presynaptic terminals.
Drenan, Ryan M. +8 more
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