Results 141 to 150 of about 139,940 (327)

Vaping and Smoking in Pregnancy—A Meta‐Analysis of Neurobehavioural Development in Prenatally Exposed Offspring

Acta Paediatrica, EarlyView.
ABSTRACT Aim Electronic cigarette usage has become increasingly popular in recent years, advertised as a safe alternative to smoking. However, the long‐term impact on prenatal development is not well understood. The aim of this systematic review and meta‐analysis is to investigate the impact of prenatal electronic cigarette exposure on self‐regulation ...
Abigail O'Connell, Rosie Rogers, Eibhlín Carys Healy, Marah Shaikhyousef, Carmen Regan, Alexander Douglass, Anne Doolan, Patricia Fitzpatrick, Des W. Cox, Michelle Downes   +9 more
wiley   +1 more source

Cholinergic modulation of the medial prefrontal cortex: the role of nicotinic receptors in attention and regulation of neuronal activity

Frontiers in Neural Circuits, 2014
Acetylcholine release in the medial prefrontal cortex is (mPFC) crucial for normal cognitive performance. Despite the fact that many have studied how acetylcholine affects neuronal processing in the mPFC and thereby influences attention behavior, there ...
Bernard eBloem, Rogier Bernard Poorthuis, Huibert Daniel Mansvelder   +2 more
doaj   +1 more source

Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential

British Journal of Pharmacology, EarlyView.
Agonists of the cannabinoid 2 (CB2) receptor have shown promise for the treatment of pain in a variety of animal models. However, despite current preclinical evidence supporting the use of CB2 agonists for pain, successful translation of findings from preclinical models to human patients is lacking.
Kelsey G. Guenther, Andrea G. Hohmann
wiley   +1 more source

Cholinergic receptor alterations in the cerebral cortex of spinal cord injured rat

Biochemistry and Biophysics Reports, 2017
Many areas of the cerebral cortex process sensory information or coordinate motor output necessary for control of movement. Disturbances in cortical cholinergic system can affect locomotor coordination.
R. Chinthu, T.R. Anju, C.S. Paulose
doaj   +1 more source

Structure–activity relationship of the allosteric effects of ivermectin at human P2X4 and GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Positive allosteric modulation of the P2X4 receptor is a potential route to providing cardiovascular benefit through enhancing flow‐dependent arterial vasodilation and providing cardioprotection. However, ligands that selectively enhance P2X4 activity are absent.
Jessica L. Meades, Marcella Bassetto, Marius C. Staiculescu, Gayathri Swaminath, Samuel J. Fountain   +4 more
wiley   +1 more source

Evaluation of the cholinomimetic actions of trimethylsulfonium, a compound present in the midgut gland of the sea hare Aplysia brasiliana (Gastropoda, Opisthobranchia)

Brazilian Journal of Medical and Biological Research, 2002
Trimethylsulfonium, a compound present in the midgut gland of the sea hare Aplysia brasiliana, negatively modulates vagal response, indicating a probable ability to inhibit cholinergic responses.
C.M. Kerchove, R.P. Markus, J.C. Freitas, L.V. Costa-Lotufo   +3 more
doaj   +1 more source

Monoclonal antibodies directed against the neurotransmitter binding site of nicotinic acetylcholine receptor [PDF]

, 1980
Richard W. James, Ann C. Kato, Marie-Joseph Rey, Bernard W. Fulpius   +3 more
openalex   +1 more source

Nicotinic acetylcholine receptors and nicotine addiction: A brief introduction

Neuropharmacology, 2020
Ruthie E. Wittenberg, S. Wolfman, M. Biasi, J. Dani   +3 more
semanticscholar   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Impact of Prior Intravenous Immunoglobulin and Plasmapheresis on Eculizumab or Ravulizumab Treatment for Generalized Myasthenia Gravis: An Analysis of the MG SPOTLIGHT Registry

Clinical and Experimental Neuroimmunology, EarlyView.
ABSTRACT Objective The complement component 5 inhibitor therapies (C5ITs) eculizumab and ravulizumab are approved for the treatment of generalized myasthenia gravis (gMG). We evaluated the real‐world effectiveness and safety of eculizumab and ravulizumab in patients with gMG with or without prior intravenous immunoglobulin (IVIg) or plasma exchange ...
Akiyuki Uzawa, Ema Rodrigues, Hiroyuki Murai   +2 more
wiley   +1 more source